Objective To explore the clinical effect of mifepristone combined with Guizhifuling tuckahoe capsule for the treatment of uterus myoma,and to observe and analyze the prognosis and provide the basis for clinical treatment.Methods 150 uterus myoma patients were selected and randomly divided into the observation group and the control group according to the treatment number,75 cases in each group.The control group was treated with mife-pristone,the observation group was treated with mifepristone combined with Guizhifuling capsule.Treated for 12 weeks and the clinical therapeutic effect and the adverse reaction were evaluated.The follicle stimulating hormone (FSH), estradiol (E2 )levels before and after treatment were detected.Results The cure rate of the observation group was 85.33% (64 /75),which was higher than that of the control group 77.33% (58 /75),the difference was statistically significant (χ2 =10.35,P <0.05).The incidence rate of adverse reaction between the two groups had no statistically significant difference (P >0.05).The menstruation,menstrual volume and tumor size of the observation group after treatment were (47.50 ±3.85)mL,(4.15 ±1.22)mm and (11.26 ±0.98)cm3 respectively,which were lower than the control group after treatment,two groups were lower than that before treatment,the differences were statistically significant (t =9.88,10.13,10.22,all P <0.05).Serum FSH and LH levels of the observation group after treatment were (32.06 ±2.75)U /L and (31.16 ±2.13)U /L,which were lower than the control group after treatment,two groups were lower than that before treatment,the differences were statistically significant (t =9.67,10.04,all P <0.05).Serum E2 of the observation group was (51.40 ±3.34)pmol/L,which was higher than that of the control group (39.32 ±3.26)pmol/L,the two groups were higher than before treatment,the difference was statistically signif-icant (t =9.81,P <0.05).Conclusion Application of mifepristone combined with Guizhifuling capsule for the treatment of uterus myoma patients with child -bearing period has better clinical efficacy and can significantly improve patients menstrual status and sex hormone secretion.The adverse reactions has no significant differences.It is worth of clinical application.

Objective To explore the clinical efficacy of Baofukang suppository and policresulen in the treat-ment of cervical erosion,and to observe and analyze the safety,thus to provide the basis for clinical treatment.Methods 268 patients with cervical erosion were selected,they were randomly divided into the control group and the observation group,134 cases in each group.The control group was treated with Baofukang suppository on the basis of conventional treatment.The observation group received Baofukang suppository and policresulen treatment.To assess the treatment effect of the two groups,and the wound healing time,improvement of the symptoms or signs and the vaginal adverse reactions were observed.Results The total effective rate of the observation group was 88.81% (119 /134),which was higher than that of the control group 79.85% (107 /134),the difference was statistically significant (χ2 =9.87, P <0.05).The wound healing time of the observation group was (23.31 ±1.78)d,which was shorter than that of the control group (27.58 ±1.96)d,the difference was statistically significant (t =11.20,P <0.05).The incidence rates of lumbosacral pain,leucorrhea and purulent secretions of the observation group after treatment were 9.70%(13 /134),5.94% (8 /134)and 3.73% (13 /134),which were lower than those in the control group after treatment [14.93%(20 /134),12.69% (17 /134)and 11.94% (16 /134)],and after treatment two groups were lower than those before treatment,there were statistically significant differences (χ2 =9.96,9.81,10.12,all P <0.05).After treatment,the contact bleeding of the observation group and the control group were 0.00% (0 /134)and 1.49%(2 /134),which were lower than those before treatment,the differences were statistically significant (χ2 =11.30,10.06, all P <0.05).The incidence rate of vagina adverse reaction of the observation groups was 17.16% (23 /134),that of the control group was 17.91% (24 /134),there was no statistically significant difference (P >0.05).Conclusion Baofukang suppository combined with policresulen has better clinical curative effect in the treatment of cervical ero-sion,which can shorten the wound healing time,reduce symptoms or signs of patients,and has high security.

Diabetic kidney disease (DKD) is one of the primary causes of end-stage renal disease (ESRD).Early diagnosis is very important in preventing the development of DKD.Urinary albumin excretion rate (UAER) and glomerular filtration rate (GFR) are widely accepted as criteria for the diagnosis and clinical grading of DKD,and microaibuminuria has been recommended as the first clinical sign of DKD.The natural history of DKD has been divided into three stages:normoalbuminuria,microalbuminuria,and macroalbuminuria.However,this clinical paradigm has been questioned recently,as studies have shown that a portion of diabetes mellitus (DM) patients with normoalbuminuria have progressive renal insufficiency,referred to as normoalbuminuric diabetic kidney disease (NADKD) or nonalbuminuric diabetic nephropathy.Epidemiologic research has demonstrated that normoalbuminuric diabetic kidney disease is common,and the large number of NADKD patients suggests that the traditional paradigm needs to be shifted.Currently,the pathogenesis of NADKD remains unclear,but many clinical studies have identified some clinical and pathological features of NADKD.In addition,the long-term outcomes of NADKD patients remain controversial.In this article,we reviewed the latest studies addressing the pathogenesis,pathology,treatment and prevention of NADKD.

Objective To investigate the epidemiological information of patients in pre-hospital medical care for our large and medium-sized cities and probe the patients' characteristic. Method The data in 2008 were exported from the computer databases of 8 large and medium-sized cities' emergency medical centers in our country.The thorough records of data were conducted to statistical analysis. Results ( 1 ) The scheduling time, running time, rescue time, returning time, total time and service radius in the pre-hospital medical care group were 2.16± 1.10(min), 14.01 ±6.82(min), 12.12±5.96(min), 14.08± 6.85(min), 42.34± 20.21(min)and 8.50±4.18(km), and the above parameter in the non-death group were 2.19 ± 1.13(min), 14.15 ± 7.14(min),11.60±6.72(min), 14.92 ±6.89(min), 41.86± 19.53(minutes) and 8.63±4.31(Km), and the above parameter in the death group were 2.10± 1.08(min), 13.68 ± 7.14(min), 25.25 ± 12.34(min), 13.75±6.48(min), 54.74 ± 25.47(min) and 7.86± 3.91(Km), and the above parameter in the non-sudden cardiac death group were2.09± 1.03(min), 13.58±6.78(min), 25.53± 12.34(min), 13.60± 6.54(min), 53.79±23.77(min) and 7.67 ± 3.86(Km), and the above parameter in the sudden cardiac death group were 2.12 ±1.02(min), 14.10±7.05(min), 24.79± 12.08(min), 13.79±6.61(min), 54. 80 ± 25. 36( min) and 7.90±3.92(Km) respectively. The scheduling time, running time, returning time and service radius in the death group were less than those of the non-death group, but the rescue time and total time of the former were more than those of the latter respectively ( P ＜ 0.05 or P ＜ 0. 001 ). The scheduling time and returning time didn' t have significant difference between the sudden cardiac death group and the non-sudden cardiac death group respectively ( P ＞ 0.05), but the running time, total time and service radius of the sudden cardiac death group were more than those of the non-sudden cardiac death group, and the rescue time of the former was less than that of the latter respectively ( P ＜ 0.05 or P ＜ 0.001 ). (2)The patients' amount in pre-hospital medical care group, the non-death group, the death group, the non-sudden cardiac death group and the sudden cardiac death group were at most in first quarter, and the least time slice of patients' amount were 4:00～ 6:00, 4:00～6:00, 4:00～ 6:00, 22:00～ 24:00, 2:00～4:00 respectively, and the most time slice of patients' amount were 20:00～ 22:00, 20:00～22:00, 8:00～ 10:00, 2:00 ～ 4:00, 8:00 ～ 10:00 respectively. (3)In 241 876 cases of pre-hospital medical care group, the patients' amount of trauma was at most, whose age grades was by far among21 ～50, and the others in sequence were nervous system, circulatory system, other group, digestive system, respiratory system and poisoning group respectively, whose age grades in nervous system, circulatory system and respiratory system was by far above 51, especially above 70. The patients' age grades in other group and digestive system had two climax age groups, which the one was 21 ～ 30, and the other was above 70. The patients' age grades in poisoning group was by far among 21 ～ 50, which the patients' amount of acute alcoholism was at the most. (4) In 12 568 cases of death group, the death amount of circulatory system, other group, respiratory system, nervous system and digestive system ranked at the lst,2nd,4th,5th 8th respectively, whose age grades was by far above 51, especially above 70,and the patients' amount of sudden cardiac death was at the most in the death amount of circulatory system. The death amount of trauma and poisoning group ranked at the 3rd, 6th respectively, whose age grades was by far among 21 ～ 50. (5)The total amount, the death amount and the sudden cardiac death amount of male patients were more than those of female patients. (6)The percentage of the death group to the pre-hospital medical care group was 5.20%, and the percentage of the sudden cardiac death group to the pre-hospital medical care group was 1.29%,and the percentage of the sudden cardiac death group to the death group was 24.87 %, and the percentage of the sudden cardiac death group to the circulatory system group was 67.33 %. Conclusions ( 1 )The trauma and the sudden cardiac death are the overriding reason of disease and the overriding reason of death in our large and medium-sized cities respectively. (2) It is very important to cut the death rate of the middle-old age patients by strengthening prevention and cure of cardiovascular and cerebrovascular diseases, discerning the critical illness early and improving the level of pre-hospital medical care. (3)It is a strong method to decrease the total amount and the death amount of the trauma, especially in traffic accident, by strengthening safety in production, observing traffic regulation and enhancing the legal awareness.

OBJECTIVETo understand the distributions of DNA and neutralizing antibodies of human papillomavirus (HPV)16, 18 in 18-45 year-old women.

METHODSTotally, 1494 women were enrolled through multistage random sampling in Funing, Jiangsu province. Cervical exfoliated cells were collected from them for HPV DNA testing, and serum samples were taken from them for the detection of HPV16, 18 neutralizing antibodies by using pseudovirion-based neutralization assay(PBNA).

RESULTSAmong the 1494 women, 28(1.9%) and 188(12.6%) were positive for DNA and neutralizing antibody of HPV16 respectively, and 15(1.0%) and 60(4.0%) were positive for DNA and neutralizing antibody of HPV18, respectively. There were no significant differences in the detection rates of DNA and neutralizing antibody of HPV16, 18 among different age groups. About 16.7% of the women were infected with HPV16, 18, or both.

CONCLUSIONIn Funing county of Jiangsu province, most women aged 18-45 years has no immunity to HPV16 and 18, indicating that they are appropriate targets for HPV 16/18 vaccination.

Adolescent ; Adult ; Antibodies, Neutralizing ; isolation & purification ; Antibodies, Viral ; isolation & purification ; China ; DNA, Viral ; isolation & purification ; Female ; Human papillomavirus 16 ; immunology ; Human papillomavirus 18 ; immunology ; Humans ; Middle Aged ; Papillomavirus Infections ; prevention & control ; Papillomavirus Vaccines ; Young Adult