Objective: To observe the clinical effect of auricular point sticking therapy for cardiac syndrome X (CSX) in women. Methods: A total of 64 patients were randomized into two groups by the random number table, with 32 cases in each group. Patients in the control group received conventional treatment for angina, while patients in the treatment group received auricular point sticking therapy on the basis of conventional treatment. After 8 weeks of treatment, the levels of serum estradiol (E2), nitric oxide (NO) and endothelium-1 (ET-1) were compared to evaluate the therapeutic effect. Results: After 8 weeks of treatment, the total effective rate and markedly effective rate in the treatment group were significantly higher than those in the control group, and the between-group comparisons showed statistical significance (both P<0.05). After treatment, the scores of chest pain and tightness in the control group dropped significantly, and the intra-group comparisons showed statistical significance (both P<0.05); the scores of chest pain and tightness, palpitations, weakness and shortness of breath in the treatment group dropped significantly, and the intra-group comparisons showed statistical significance (all P<0.05); there were significant inter-group differences in the scores of chest pain and tightness. After treatment, the intra-group comparisons of E2, NO and ET-1 contents in the control group showed no statistical significance (all P>0.05), while the E2, NO and ET-1 contents in the treatment group changed significantly after treatment and were significantly different from those in the control group (all P<0.05). Conclusion: Auricular point sticking on the basis of conventional treatment was effective for CSX in women, and is worth clinical application.

Objective: To investigate the changes of matrine concentration in rat local skin with time after transdermal administration of matrine transfersomes, and to evaluate the transdermal delivery properties. Methods: The matrine transfersomes were applied non-occlusively onto rat skin in vivo with abdominal hair removal, and the concentration of drugs in microdialysate of skin was detected by microdialysis and reverse phase high performance liquid chromatography. Furthermore, the concentration-time curves of matrine in microdialysates of skin were compared among marine transfersomes, liposomes, and deoxysodium cholate solution. Results: After the transfersomes were given to rats, the maximum peak time (tmax) of matrine skin concentration appeared at (4.200 ± 0.447) h. The maximum skin concentration (Cmax) was (0.927 ± 0.251) μg/mL and area under the curve (AUC0-8) was (5.033 ± 1.526) μg·h·mL-1, which were much higher than those of the liposomes and the solution (containing 0.8% sodium deoxycholate, P < 0.05), while tmax shortened much more than that of them. Conclusion: In vivo skin microdialysis could be used to assess the transdermal delivery properties of matrine transfersomes. And matrine transfersomes have the good transdermal permeability and efficacy.

Objective To explore the feasible of diagnosing ischemic cerebrovascular diseases by detecting central retina artery sclerosis(CRA) with color Doppler ultrasonography.Methods210 patients with ischemic cerebrovascular disease(420 eyes) and 80 healthy volunteers(160 eyes) were examined by color Doppler flow imaging(CDFI) to detect double sides blood frequency spectrum of CRA and hemodynamic parameters of CRA including peak systolic velocity(PSV),end of diastolic velocity(EDV)and resistant index(RI).ResultsThe blood frequency spectrum of CRA showed three apices and two vales or slanting triangle in healthy volunteers.But in patients with ischemic cerebrovascular disease,the blood frequency spectrum changed,and PSV and EDV were slower and RI increased compared with those in the healthy volunteers(PP<0.05～0.001).ConclusionIn patients with ischemic cerebrovascular disease,the blood flow of CRA is slower and RI increases compared with health individuals.The color Doppler ultrasonography can used for diagnosis of CRA sclerosis.

Abstract: Objective　To analyze the treatment outcomes of elderly patients with pulmonary tuberculosis in Chongqing, so as to provide reference for the prevention and control strategies of the epidemic of elderly pulmonary tuberculosis. Methods　The data of tuberculosis cases aged ≥65 years in Chongqing from 2015 to 2020 were collected from the National Health Insurance Information Project Disease Prevention and Control Information system. Descriptive statistical methods were used to analyze the data. Results The registration rates of elderly active pulmonary tuberculosis patients and etiological positive patients were 110.95/10-5and 32.25/10-5 in 2015 and 84.06/10-5 and 57.29/10-5 in 2020. The annual decline rate of active tuberculosis registration was 5.40%, and the annual increase rate of pathogenic-positive tuberculosis registration was 12.18%. The registration rates of active tuberculosis patients and etiological positive patients in the whole population were 70.75/10-5 and 17.63/10-5 in 2015 and 50.34/10-5 and 29.14/10-5 in 2020. The annual decline rate of active tuberculosis registration was 6.58%, and the annual increase rate of pathogenic-positive tuberculosis registration was 10.57%. From 2015 to 2020, a total of 25 931 cases of elderly pulmonary tuberculosis were registered, of which 21 374 (82.43%) cases were successfully treated and 4 010 (15.80%) cases had unfavorable outcomes. The proportion of cured and death patients showed an increasing trend year by year (χ2trend=313.853, 100.502, P<0.01). From 2015 to 2020, the average annual successful treatment rate of elderly pulmonary tuberculosis in the whole city was 82.43%, with the lowest rate in southeast Chongqing (74.23%), followed by urban areas (81.99%). The success rate of elderly pulmonary tuberculosis treatment in the whole city, west Chongqing, northeast Chongqing and southeast Chongqing showed a downward trend year by year (χ2trend=230.199, 35.278, 108.076, 112.130, all P<0.01), with annual decline rates of 2.77%, 2.26%, 3.0% and 4.12%, respectively. Among the registered elderly patients, female, 65-<75 years old, Han nationality, newly diagnosed, no complications, and negative for etiology (χ2=15.234, 255.910, 146.842, 179.998, 25.575, 131.170, P<0.01) had higher success treatment rates. Conclusions The prevalence of pulmonary tuberculosis in the elderly population in Chongqing City is declining, but the positive registration rate of etiology is increasing annually, and the success rate of treatment is decreasing. Therefore, it is necessary to strengthen the systematic management, publicity and education of elderly patients (especially those in southeast Chongqing, male, positive patients and severe patients) to effectively control the epidemic of tuberculosis in the elderly.

Objective To evaluate the laparoscopic Palomo procedure in the management of varicocele in adolescent by assessment of the postoperative testicular growth and the changes of the biggest vessel diameter of varix. Methods From July 1999 to March 2004, laparoscopic high mass - ligation of testicular vessels according to Palomo procedure was performed on 31 boys who all presented with left varicocele Before and after operation at 1 month,3 and 6 months, the biggest vessel diameter of varicocele was measured by ultrasonography, testicular blood supply was evaluated by color Doppler flow imaging(CDFI) ,and fastis was recorded in length, width and thickness by ultrasonographic measurement, which volume was calculated by the formula V =?/6 ? length ? width ? thickness. Also the ratio of left to right testicular volume was calculated, and the left testicle was thought atrophy if the ratio was below 75% The biggest vessel diameter of varix, testicular blood supply, and the postoperative testicular increasing volume were compared before and after operation. Results The biggest vessel diameter of varicocele significantly reduced 1 month after operation(P

Adult ; Antiviral Agents ; therapeutic use ; Colonic Neoplasms ; diagnosis ; etiology ; therapy ; Cyclosporine ; adverse effects ; Esophageal Neoplasms ; diagnosis ; etiology ; therapy ; Female ; Ganciclovir ; therapeutic use ; Humans ; Immunosuppression ; adverse effects ; Immunosuppressive Agents ; adverse effects ; Liver Neoplasms ; diagnosis ; etiology ; therapy ; Liver Transplantation ; adverse effects ; Lymphoproliferative Disorders ; diagnosis ; etiology ; therapy ; Middle Aged ; Pharyngeal Neoplasms ; diagnosis ; etiology ; therapy ; Survival Analysis ; Tacrolimus ; adverse effects ; Time Factors

Child, Preschool ; Female ; Humans ; Male ; Shock, Septic ; etiology ; microbiology ; Streptococcal Infections ; complications ; pathology

Objective To evaluate the usage of renoportal anastomosis in the liver transplanta- tion.Method The successful experience about renoportal anastomosis for portal vein reconstruction in liver transplantation was reported,and related literature reviewed.Results Including our case,there have been 13 cases of liver transplantation using renoportal anastomosis for portal vein reconstruction. Among these patients,8 cases were complicated with diffuse portal vein thrombosis,and 10 cases had a splenorenal shunt(spontaneous shunt in 3 and surgical shunt in 7).Complications related to portal vein hypertension occurred in 3 cases(transient ascites in 2 cases and severe digestive bleeding in 1 case)after liver transplantation.There were 3 deaths which were not related to renoportal anastomo- sis.Conclusion Renoportal anastomosis is a safe and feasible technique in liver transplantation for the patients with diffuse portal vein thrombosis or with splenorenal shunt(spontaneous or surgical shunt).

According to teaching practice of "microbial engineering", teaching reforms, such as conformity and optimization of the curriculum system, improvement of teaching methods and the construction of multilevels experimental teaching system, are investigated in this paper, in order to improve the teaching quality and enhance the overall quality and the abilities of operation and innovation of students.

Heat shock proteins (HSP) are highly conserved proteins that protect cells and enhance the body's resistance to stress. Heat shock protein 27 (HSP27) also known as heat shock protein beta-1 (HSPB1) is a small molecular weight HSP that in humans is encoded by the HSPB1 gene. HSP27 exerts its effect mainly in the form of phosphorylation activity, and has a variety of important biological functions, such as chaperone activity, thermotolerance, anti-oxidation and inhibition of apoptosis. HSP27 was found to be highly expressed in a variety of intestinal diseases. This article reviews the structure, function, mechanism of action of HSP27 and the relationship between HSP27 and intestinal diseases, and explores the clinical value and application prospect of HSP27 in intestinal diseases.