1.Protective Effect of Gingko Biloba Extract on Acute Lung Hemorrhage Induced by Lipopolysaccharide in Newborn Rats
ya-ling, LIU ; dai-cheng, HAN ; chuan-xiong, XIA
Journal of Applied Clinical Pediatrics 1992;0(06):-
Objective To investigate the protective effect of Gingko Biloba extract (GBE) on acute lung hemorrhage induced by Lipopolysaccharide(LPS) in newborn rats. Methods 1. Acute lung hemorrhage models were reproduced by intraperitoneal injection with LPS (5 mg/kg). 2. Thirty two rats were randomly divided into 4 groups,GBE groups (4 mg/kg,8 mg/kg, 16 mg/kg) and LPS group 5 mg/kg. Results In group LPS, extensive lung hemorrhage was observed after 4 hours of injection . TNF - ? iung content was obvious in LPS group. The expression of lung nuclear factor(NF-kB )immunohistochemistry wasobvious. While the parameters were obviously attenuated by GBE before LPS. Conclusion GBE may be useful in the treatment of acute pulmonary inflammatory disease.
2.Study on step accuracy measurement and dose deviation of 252 Cf neutron afterloading radiotherapy machine
Mingsheng LI ; Qinghuan JIANG ; Ya LIU ; Jinsheng CHENG
Chinese Journal of Radiological Medicine and Protection 2017;37(8):626-629
Objective To study the step aceuracy of 252Cf neutron afterloading radiotherapy machine and the dose deviation caused by step deviation.Methods EBT3 film was used to measure the steps of the 252Cf neutron source,and then the center of each 252Cf neutron source was identified by measuring the optical density value by using the ImageJ software.Double ion chambersmethod was used to measure the dose deviation dlue to the 252 Cf neutron source position shift.Results 252 Cf neutron source step accuracy may amount to 0.01 mm using EBT3 film measurement,when 252Cf neutron source position deviation is less than 3 mm,the dose deviation is less than 2.5%.Conclusions The study on the step accuracy and position deviation of the 252Cf neutron source can provide a reference for the quality control standard of the 252Cf neutron afterloading radiotherapy machine.
4.The study of temporal bone scanning at low-dose with 64-slice spiral CT
Heng-Tao QI ; Wei-Chang QIN ; Cheng LIU ; Dao-Cai WANG ; Chuan-Ya LIU ; Wei WANG ;
Chinese Journal of Radiology 2001;0(02):-
Objective To study the rationality and possibility of 64 slice spiral CT in the examination of the temporal bone at low dose.Methods The same CT technique and temporal bone mode as those for clinical CT were used,two cranium specimens(four ears)were scanned with Somatom Sensation 64-slice spiral CT at different mA(380,300,200,160,120,80),and muhi-planar reformation was performed.The CT dose index at different mA groups were measured by 10 cm pencil ionization chamber and head dose phantom.Four anatomic structures on axial images(subarcuate fossa,tendon of tensor tympani, facial recess,etc),four anatomic structures on coronal images(scute,crista transversa,fenestra cochleae, etc)and six anatomic structures on double oblique images(malleus,incus,stirrup bone,upper bony semicircular,etc)were chosen to evaluate and grade the reformation images among different mA groups,and to determine the minimum mA value.Ten ears of five patients were used to test the validity of the minimum mA value.Results CT radiation dose was significantly reduced from(47.8?2.7)to(20.1?2.0)raCy (P
5.Clinical Analysis of 32 Children with Measles Complicated with Severe Pneumonia and Acute Respiratory Distress Syndrome
ya-jun, LIU ; xiao-jun, TANG ; cheng-jun, LIU ; ren-yi, YANG
Journal of Applied Clinical Pediatrics 2006;0(22):-
Objective To explore the clinical characteristics and the remedial measurement of measles complicated with severe pneumonia and the acute respiratory distress syndrome(ARDS) in children.Methods From Jan 2004 to Jul 2007,clinical data of 32 cases with measles complicated with severe pneumonia and ARDS in PICU of Chongqing Children's Hospital were retrospective analyzed.In addition,the ratio of partial pressure of oxygen in arterial blood fractional concentration of oxygen in inspired gas[pa(O2)/FiO2] between the death group and survival group,the mortality rates between the hormone therapy group and control group were performed.Results Sixteen cases were cured and 16 cases were died,with the mortality rate 50%.The ratio of pa(O2) /FiO2 before mechanical ventilation in death group was lower than that in the survival group [(11.93?1.67) kPa,(21.77?1.16) kPa,respectively,P0.05).Conclusions ARDS is a severe complication in children with measles pneumonia and associated with a high mortality,which requires early diagnosis and intervention to improve survival rate and prognosis.The ratio of pa(O2)/FiO2 may provide reference to evaluation for severity and prognosis of ARDS.
6.Analysis and Discussion on Calculating Likelihood Ratio of DNA Mixture.
Ying LIU ; He REN ; Lin-lin GAO ; Yan SHI ; Chong CHEN ; Ya-cheng LIU
Journal of Forensic Medicine 2015;31(6):441-444
OBJECTIVE:
To analyze and discuss four methods of calculating likelihood ratio of DNA mixture.
METHODS:
In the case with CNAS-T0757 proficiency testing in 2013, the likelihood ratios were calculated and compared among four methods, including unrestricted combinatorial method, Clayton's method, p2 principle method, and recommendations from ISFG.
RESULTS:
The likelihood ratios were maximum by Clayton's method and recommendations from ISFO, followed by result of the unrestricted combinational method. The minimum likelihood ratio was obtained by p2 principle.
CONCLUSION
The unrestricted combinational method could give fUrthest consideration to both information preservation and appraiser protection.
DNA/genetics*
;
DNA Fingerprinting
;
Humans
;
Likelihood Functions
7.Comparison inhibitory effect of bleomycin and carmustine on craniopharyngiomas cultured in vitro
Rongcai JIANG ; Cheng ZHU ; Zonghui LIU ; Zengmin TIAN ; Hairong ZHANG ; Yingchun ZHU ; Ya WANG
Academic Journal of Second Military Medical University 2001;0(09):-
Objective: To compare the inhibitory effect of carmustine(BCNU) and bleomycin on craniopharyngiomas in vitro. Methods: Cells were successfully cultured in vitro from the fresh specimens, then the culture medium with bleomycin or BCNU at different concentration was added. The tumor inhibitory curve-line was drawn based on the cell number at different time points. After cultured for 144 h, ATP-luminescence assay was applied to test the antitumor effect. Results: The cell number decreased rapidly when the medium was added. The decreasing speed was faster in BCNU medium than that in bleomycin medium at the same concentration. The bleomycin medium showed no significant inhibitory effect except for the one at 1.00 g/L. However, regardless of the concentration, BCNU medium inhibited the cells effectively. Conclusion: BCNU has stronger inhibitory effect on craniopharyngiomas cells than bleomycin, it can be used to treat this tumor
8.E2E testing of Cyberknife lung tracking using a homemade lung phantom
Xiao WEI ; Xiangjie MA ; Mingsheng LI ; Zhengzhao ZHANG ; Ya LIU ; Yuze YANG ; Jinsheng CHENG
Chinese Journal of Radiological Health 2024;33(1):1-6
Objective :
To verify the feasibility of using a homemade lung phantom for quality control of Cyberknife by
comparing the measurement results of the homemade lung phantom and CIRS dynamic phantom in E2E testing of Cyberknife lung tracking.
Methods :
The patient treatment process was simulated, including CT positioning, plan design, irra-
diation implementation, film scanning, and analysis using the homemade phantom and CIRS phantom. The two phantoms
were measured five times using MLC under the S7 generation Cyberknife and five times using Iris under the M6 generation
Cyberknife. The differences in measurement results between the two phantoms were analyzed using independent sample t-test.
Results :
For the S7 generation Cyberknife, the statistical analysis of differences between the two phantoms in the detection values on the X-axis, Y-axis, Z-axis, and total deviation showed P values of 0.236, 0.175, 0.289, and 0.668, respect-
ively. For the M6 generation Cyberknife, the statistical analysis showed P values of 0.880, 0.891, 0.573, and 0.433, respect-
ively. The P values were all > 0.05. Therefore, there were no statistically significant differences in the detection results
between the homemade lung phantom and the CIRS phantom under the S7 and M6 generation Cyberknife. The total deviation values were <1.5 mm.
Conclusion
The homemade lung phantom and CIRS phantom have consistent measurement
results in the E2E testing of Cyberknife lung tracking and meet the requirements of Report of AAPM TG-135 and WS 667-
2019 standard. Therefore, the homemade lung phantom is feasible for clinical quality control of Cyberknife.
9.Analysis of curative effect of chondroitin sulfate and glucnsamine sulfate on Kaschin-Beck disease
Hui, LIU ; Wei, DONG ; Ya-xu, ZHANG ; Qing, DENG ; Jiu-cheng, SONG ; Ben, GAO ; Ning, LIU ; Yun-qi, LIU
Chinese Journal of Endemiology 2010;29(1):98-100
Objective To research the curative effect of chondroitin sulfate and glucosamine on Kashin-Beck disease(KBD). Methods According to Diagnosis for Kashin-Beck disease,80 patients of adult KBD were detected from Guanghui village Shangzhi city Heilongjiang province in July,2007,and they divided into treatment group and control group according to their condition,age and sex,40 person in each group. Treatment group was given chondroitin sulfate and glucosamine sulfate,and control group was given placebo(equivalent amount of starch). Bilateral knees X-ray films were shot before and after treatment (8th month),scale division magnifying glass was used to measure the width of joint space on X-ray films. Results The width of joint space respectively was (4.30±2.14) and (4.10±2.07)mm in control group before and after treatment,and treatment group respectively was (4.17±2.15),(4.16±2.11)mm. Medicine had no obviously role on joint space (F = 0.50,P > 0.05),Time and both of time and medicine had obvious role on joint space(F= 67.66,46.74,all P< 0.05). Joint space of treat group was thinner than control group(P < 0.05) before treatment,but thicker after treatment(P < 0.05). To compare with the width of before treatment,joint space width of control group became obviously narrow(P < 0.05). Conclusions Experimental group taking chondroitin sulfate and glucosamine sulfate alleviated knee joint space narrowing process of adults KBD patients compared with control group. It plays a protection role in articular cartilage and provides evidences for choosing drug and evaluating effect in the treatment of adults KBD.