BACKGROUND: Most of the dental metal repair materials contacting Ti implants will cause galvanic corrosion and local environment with positive electricity on the implant interface, which directly affects the status of the tissues, especially bone resorption.OBJECTIVE: To evaluate the galvanic corrosion of commercially pure Ti (TA2 type) coupled with Au alloy, CoCr alloy, Ti alloy, and NiCr alloy in vitro. METHODS: Circuit of commercially pure Ti contacting with Au alloy, CoCr alloy, Ti alloy, and NiCr alloy was simulated in vitro in artificial saliva, and the common potential and galvanic current in 15 hours were recorded to draw current-time curves. RESULTS AND CONCLUSION: The galvanic current became stable after 8 hours of contacting. The galvanic current was the greatest in Ti/Au, followed by Ti/CoCr, Ti/Ti alloy, and then Ti/NiCr. Results indicated that the galvanic corrosion of the couple of Ti and Au alloy is the lowest. Au alloy is the most suitable material for implant superstructure. The galvanic corrosion of the couple of Ti and NiCr alloy is the highest, so NiCr alloy is not acceptable for implant superstructure.

Objective Based on the 2012 Atlanta classification criteria, to study the value of C-reactive protein (CRP) and procalcitonin (PCT) in the early forecasting acute pancreatitis (AP). Methods Eighty-three patients with AP were selected. The patients were divided into mild AP (MAP) group (39 cases), moderately severe AP (MSAP) group (31 cases) and severe AP (SAP) group (13 cases) according to the 2012 Atlanta classification criteria. Twenty-seven healthy people were selected as control group. The levels of serum CRP and PCT were measured. The predictive value of serum CRP and PCT levels for SAP, infectious pancreatic necrosis (IPN), organ failure and death risk was assessed using the area under the curve (AUC). Results The serum CRP and PCT levels in MAP group, MSAP group and SAP group were significantly higher than those in control group: (49.84 ± 12.26), (89.77 ± 22.10) and (123.69 ± 37.09) mg/L vs. (3.92 ± 1.37) mg/L, (1.15 ± 0.42), (2.44 ± 0.61) and (3.27 ± 0.96)μg/L vs. (0.41 ± 0.13)μg/L, and those in MSAP group and SAP group were significantly higher than those in MAP group, those in SAP group were significantly higher than those in MSAP group, and there were statistical differences (P<0.05). The Spearman correlation analysis result showed that AP severity was positively correlated with serum CRP and PCT levels (r = 0.652 and 0.714, P<0.05). The accuracy of serum CRP level for forecasting SAP and IPN was medium (AUC = 0.73 and 0.76), and for forecasting organ failure accuracy was low (AUC = 0.67). Serum CRP showed no significance in forecasting death risk (AUC = 0.46). The accuracy of serum PCT level for forecasting SAP, IPN and death risk accuracy was medium (AUC = 0.71, 0.86 and 0.80), and for forecasting organ failure accuracy was low (AUC =0.64). Conclusions Based on the 2012 Atlanta classification criteria, the accuracy of serum CRP level for forecasting SAP is higher than that of serum PCT level, the accuracy of serum PCT level for forecasting IPN and death risk is higher than that of serum CRP level, and accuracy of serum CRP and PCT levels for forecasting organ failure are low.

Novel targeted drugs and clinical trails have become the research highlights of non-Hodgkin lymphoma (NHL) recently. With further studies on immunotherapy in NHL, a number of novel immunotherapeutic targeted agents have been developed, some of which also had showed clinical benefit in early-stage study. The advances on novel immunotherapeutic targeted agents in NHL will be comprehensively reviewed in this paper from three aspects, including the targeted monoclonal antibody of cell surface antigen, the targeted therapy of cell signal transduction pathway and lymphoma microenvironment.

Object An attempt to seek after an intrinsic inhibitor present in the seed of Astragalus membranaceus (Fisch.) Bge.. Methods Crude ethereal extract of the seed was prepared and treated on paper chromatography. Inhibitory effects of different fractions with different Rf value were tested on Brassica chinensis L. and wheat germination. Effect of steeping the seed in warm water at 41 ℃ or 45 ℃ for different periods of time was also studied.Results Seed of A. membranaceus does contain strong intrinsic inhibitor. The portion of its ethereal extract with Rf 0.9 showed the most strong inhibition for the germination of Brassica, and the fraction with Rf 1.0 can inhibit the growth of the tender Brassica root, steeping with warm water can remove most of the intrinsic inhibitor, which also inhibits the growth of both aerial and underground parts of wheat sprouts, but without effect on its seed germination. It also showed strong inhibition of seed germination and growth of tender root of A. membranaceus. Conclusion Besides the low water permeability of the seed peel, the intrinsic inhibitor present in A. membranaceus is another essential factor that retard its germination.

Antibodies, Monoclonal ; therapeutic use ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents, Hormonal ; therapeutic use ; Breast Neoplasms ; metabolism ; pathology ; therapy ; Female ; Humans ; Lymphatic Metastasis ; Receptor, ErbB-2 ; metabolism ; Receptors, Estrogen ; metabolism ; Receptors, Progesterone ; metabolism ; Signal Transduction ; Tamoxifen ; therapeutic use ; Trastuzumab

Adult ; Drug Combinations ; Drugs, Chinese Herbal ; adverse effects ; Female ; Fever ; chemically induced ; Humans ; Injections ; Male ; Middle Aged

Clinical Medicine ; Humans ; Neoplasms ; prevention & control ; Periodicals as Topic ; Research

Adult ; Dry Eye Syndromes ; Female ; Humans ; Male ; Occupational Diseases ; Welding ; Young Adult

Objective: To observe the expression of VEGF in the spinal vascular malformations by immunohistochemical staining. This study will provide useful information for better understanding of the etiology and development of the spinal vascular malformations. Methods: The specimens (including 31 AVMS, 17 CMs) were collected as the experimental group. Ten specimens of normal spinal cord were obtained from autopsy served as the control group. VEGF expression were performed by immunohistochemistry and all the stained sections were observed under light microscope recording the positive site. SPSS 11.0 statistical software were used to analyze the relationship between VEGF and some clinical features. Results: All 58 lesions were stained positive for VEGF, with the SCAVMs staining somewhat more intensely (P < 0.01) and the control group are almost negative staining. Bleeding and pre-embolization can lead to the raising of expression of VEGF. To the SCAVM group, the expression of VEGF on inner membrane and tunica media stains more intensely than ectal membrane. And the artery showed more positive staining than vein. Conclusion: VEGF maybe play an important role in the etiology and development of spinal vascular malformations. Haemorrhagia and embolism influence the express of VEGF in vascular malformations of spinal cord.

Objective: To observe the clinical effect of auricular point sticking therapy for cardiac syndrome X (CSX) in women. Methods: A total of 64 patients were randomized into two groups by the random number table, with 32 cases in each group. Patients in the control group received conventional treatment for angina, while patients in the treatment group received auricular point sticking therapy on the basis of conventional treatment. After 8 weeks of treatment, the levels of serum estradiol (E2), nitric oxide (NO) and endothelium-1 (ET-1) were compared to evaluate the therapeutic effect. Results: After 8 weeks of treatment, the total effective rate and markedly effective rate in the treatment group were significantly higher than those in the control group, and the between-group comparisons showed statistical significance (both P<0.05). After treatment, the scores of chest pain and tightness in the control group dropped significantly, and the intra-group comparisons showed statistical significance (both P<0.05); the scores of chest pain and tightness, palpitations, weakness and shortness of breath in the treatment group dropped significantly, and the intra-group comparisons showed statistical significance (all P<0.05); there were significant inter-group differences in the scores of chest pain and tightness. After treatment, the intra-group comparisons of E2, NO and ET-1 contents in the control group showed no statistical significance (all P>0.05), while the E2, NO and ET-1 contents in the treatment group changed significantly after treatment and were significantly different from those in the control group (all P<0.05). Conclusion: Auricular point sticking on the basis of conventional treatment was effective for CSX in women, and is worth clinical application.