In this paper,the teaching in medical microbiology experiment to the first group of foreign students in our college is analyzed and summarized,which will give us many experiences for later teachering.

As a representative of controlled release preparations, osmotic pump has become a hot spot in the new preparation researches of Chinese materia medica (CMM). This paper reviewed CMM osmotic pump preparation from the following aspects: structure type of osmotic pump preparation, adjuncts of osmotic pump preparation of CMM, in vivo evaluation, and problems existing currently, which aimed to provide ideas and methods for the development of CMM osmotic pump preparation.

Eosinophilic gastroenteritis (EGE) is a rare chronic disease of digestive system, characterized by the eosinophil infiltration of the gastrointestinal tract and the thickening of the gastrointestinal wall. At present, the etiology and pathogenesis of EGE are still unclear. Accompanied with eosinophilia and elevation of serum immunoglobulin E, the clinical manifestations of EGE are dependent on the location of lesions and the extent or depth of eosinophil infiltration in the gastrointestinal tract. The thickening or edema of the gastrointestinal wall, nodular-like changes, intestinal stenosis and ascites can be regarded as common radiological findings of EGE, while erythema, hyperemia or edema, erosion and ulcer of mucosal are the endoscopic features of EGE. Tissue biopsy is helpful for the diagnosis of EGE. However, with unspecific clinical manifestations, laboratory tests, radiological and endoscopic findings and unidentified cut-off count of pathological diagnostic criteria, EGE is very difficult to be diagnosed. Therefore, this paper mainly reviews the research progress in the diagnosis and treatment of EGE, attempting to improve the clinicians' understanding of EGE.

Hearing Loss ; genetics ; Humans ; Mitochondria ; genetics ; Mutation

0 05), but MTT had significant difference( F =10 2, P

?DJ-1 has been reported to act as aredox-activated chaperone and sensor of oxidative stress participated in a variety of activities in cellular, playing an important role in resisting oxidative stress, regulating signaling pathways and gene transcription, and maintaining mitochondria dynamic balance. DJ -1 is closely related to the occurrence and development of various diseases. Recently, the effect of DJ-1 in eye diseases has drawn more attention, and researchers have found its significant role of resistance to oxidative stress in the pathogenesis of Fuchs endothelial corneal dystrophy ( FECD) and age-related macular degeneration ( AMD ) .This review will state the mechanism of DJ-1 against oxidative stress and its role in the development of eye diseases.

Respiratory dysfunction is the primary cause of death early after cervical spinal cord injury, and it can be restored by electrical stimulation, magnetic stimulation, nerve transfer surgery, and cell transplantation. This paper reviewed the anatomy, clinical manifestations,and associated restoration techniques of respiratory muscle dysfunction after cervical spinal cord injury.

The development, application and revision of the clinical practice guideline (CPG) in traditional Chinese medicine (TCM) are a whole thing. However, the development and revision of TCM CPGs have been influenced due to lack of TCM CPGs reporting and feedback channel. Therefore, during the TCM standardization network establish-ment, we studied the application model of TCM CPGs with spontaneous reporting network, in order to provide the ba-sis for further TCM CPGs development and revision.

Amounts of researches show that EPO is characterized with neurotrophic and neuroprotective manner, especially in brain stroke, which attracts a large numbers of researchers to study it. With the accumulating researches on its neuroprotection, many related mechanisms were revealed, such as antioxidant, anti-apoptosis, angiogenesis, anti-inflammatory, which suggests a multiple targets role of EPO on brain stroke. However, because of the high risk of thromboembolism in clinical administration of rhEPO and its analogs, the herbs are potential to be a replacer for its less side effects. Many researchers suggested that a larger of herbs were founded having the action of increasing the endogenous EPO in the model of anemia and cerebral ischemia. At the same time, there herbs were also proved that they had the action of against cerebral ischemia while some without considering the role of EPO in the reports. Considering of the action of promoting EPO of these herbs and the neural protection of EPO, this essay mainly summarizes the studies of herbs promoting EPO in the cerebral ischemia and discusses the mechanism of regulating the EPO of these herbs, for the aim of finding the potential drugs against cerebral ischemia.
Animals ; Brain Ischemia ; drug therapy ; genetics ; metabolism ; Drugs, Chinese Herbal ; pharmacology ; Erythropoietin ; genetics ; metabolism ; Humans ; Neuroprotection ; drug effects ; Plants, Medicinal ; chemistry

In this paper, the Boosting-based decision tree ensemble classifiers were applied to discriminate thermophilic and mesophilic proteins. Three methods, namely, self-consistency test, 5-fold cross-validation and independent testing with other dataset, were used to evaluate the performance and robust of the models. Logitboost, as a novel classifier in Boosting algorithm, performed better than Adaboost. The overall accuracy of the three methods was 100%, 88.4% and 89.5%, respectively. It was demonstrated that LogitBoost performed comparably or even better than that of neural network, a very powerful classifier widely used in biological literatures. The influence of protein size on discrimination was addressed. It is anticipated that the power in predicting many bio-macromolecular attributes will be further strengthened if the Boosting and some other existing algorithms can be effectively complemented with each other.
Algorithms ; Decision Trees ; Molecular Weight ; Neural Networks (Computer) ; Proteins ; chemistry ; classification