1.Advances in the study of precise radiotherapy for non-small-cell lung cancer
Journal of International Oncology 2006;0(10):-
With the development of computer techniques and medical imaging examining methods , precise radiotherapy is becoming the major direction of radiotherapy for tuomors. Both of tumor control probability and normal tissue complication probability are improved with precise radiotherapy. This paper critically review the value of PET-CT and breathing control in precise radiotherapy for non-small-cell lung cancer (NSCLC).
3.Analysis of apnea in 229 cases of very low birth weight infants.
Xiu-jing WU ; Ya-ping XU ; Li-ping SHI
Chinese Journal of Pediatrics 2003;41(8):622-623
Apnea
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epidemiology
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pathology
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therapy
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Birth Weight
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China
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epidemiology
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Female
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Gestational Age
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Humans
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Infant, Newborn
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Infant, Very Low Birth Weight
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Male
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Risk Factors
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Time Factors
4.Ethical Problems on Collection,Storage and Use of the Important Disease Genetic Resources
Ya TUO ; Xiaolong XU ; Ping HUANG ; Ping ZHANG ; Shengbin LI
Chinese Medical Ethics 1994;0(05):-
In the modern biotechnology era,the important disease genetic resources become the most dependent factor.We expound the actuality of the collection,storage and use of the important disease genetic resources in China,and discuss the problems and challenges we meet.So the chief mission we should do is establishing the database and collecting,storing and using these valuable resources under standard procedure with aim,plan and organization.
9.Compound Heterozygosis Mutation of Low Density Lipoprotein Receptor Gene in Familial Hypercholestero-lemia Family
xiao-dong, PAN ; lu-ya, WANG ; jie, LIN ; peng-yu, SU ; ya, YANG ; shu, LIU ; lan-ping, DU ; xu, WANG
Journal of Applied Clinical Pediatrics 2006;0(13):-
Objective To identify mutations site and clinical characteristics of a familial hypercholesterolemia(FH) proband diagnosed clinically through DNA sequencing and family analysis in the proband and his family members of 3 generations.Methods Blood samples and clinical data of the kindred of total 29 from 3 generations members were collected.Proband had a physical examination electrocar-diogrom and vascular ultrasound.The proband and his family members took routine clinical exams,and genomic DNA was isolated.The promoter region and the 18 exons of low density liporotein receptor(LDLR) gene were screened by Touch down polymerase chain reaction -single strand conformation polymorphism(PCR-SSCP) and DNA sequencing.The result of sequencing were matched gene sequence published in the BLAST database.Results 1.Increased intima-media thickness and plaque were detected in the common carotid artery,right subclavian artery of the proband.Aortic valve regurgitation was found by echocardiography.2.No mutation R3500Q of ApoB100 was observed.3.Two heterozygous mutations in exon 10 and 13 of LDLR gene (W462X and A606T) were identified.The proband and 5 members of paternal relatives showed W462X heterozygosis mutation in exon 10 of LDLR gene which introduced the change from tryptophone to a new stop codon.The proband's mother and grandmother harboured A606T heterozygous mutation in exon 13 of LDLR gene due to a single base pair substitution of G for A in the codon for residue 1 879.Conclusions Disease causing mutations of proband are W462X and A606T compound heterozygosis mutation in exon 10 and 13 of LDLR gene inherited from mother and father.Proband shows homozyous phenotype though the genotype analysis indicates heterozygous mutations.
10.Synergetic effect of flue gases and arsenic on DNA injury in lymphocytes.
Yi WANG ; Chun-wei LU ; Lu WANG ; Ya-ping JIN ; Yuan-yuan XU ; Gui-fan SUN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(3):175-177
Animals
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Arsenic
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toxicity
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Comet Assay
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DNA Damage
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drug effects
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Lymphocytes
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drug effects
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metabolism
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Male
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Malondialdehyde
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metabolism
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Rats
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Rats, Wistar
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Tobacco Smoke Pollution
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adverse effects