4.Advances in research on the association between single nucleotide polymorphisms of the DNA repair genes and resistance to platinum-based chemotherapy.
Jia WEI ; Bao-rui LIU ; Ya-ping WANG
Chinese Journal of Oncology 2006;28(3):161-163
DNA Repair
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genetics
;
DNA-Binding Proteins
;
genetics
;
Drug Resistance, Multiple
;
Drug Resistance, Neoplasm
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Endonucleases
;
genetics
;
Humans
;
Neoplasms
;
drug therapy
;
genetics
;
Nuclear Proteins
;
genetics
;
Organoplatinum Compounds
;
therapeutic use
;
Platinum Compounds
;
therapeutic use
;
Polymorphism, Single Nucleotide
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Transcription Factors
;
genetics
;
X-ray Repair Cross Complementing Protein 1
;
Xeroderma Pigmentosum Group D Protein
;
genetics
5.Bronchogenic cyst in gastric wall.
Wei-ya WANG ; Li-li JIANG ; Wei-ping LIU ; Wen-yan ZHANG
Chinese Journal of Pathology 2005;34(6):380-381
Bronchogenic Cyst
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pathology
;
surgery
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Diagnosis, Differential
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Gastrectomy
;
methods
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Humans
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Male
;
Middle Aged
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Stomach Diseases
;
pathology
;
surgery
6.Investigation of transmission and protection in family of pulmonary MDR-TB
Yu-Sen CUI ; Ping WU ; Qi-Ping GE ; Ya-Dong DU ; Wei-Wei GAO
Chinese Journal of Modern Nursing 2010;16(12):1402-1404
Objective To investigate the situations of close contacting with MDR-TB in family and analysis the necessity and urgency of family protection.Methods Nine typical primary MDR-TB cases in our hospital that close contacted with family pulmonary TB patients.their relatives contacted with them and their treatment prognosis were retrospectively analyzed.Results All of the 9 cases were transmitted by lineal MDR-TB relatives.In one case,3 generations were pumonary TB patients.All of 4 family members were pulmonary TBpatients in another case.3 cases were treated with operations:2 cases with pulmonary lobectomy and 1 case with intestinal resection.Treatment prognosis:3 cases cured,2 cases not cured,4 cases dead.Conclusions Family close contacting with MDR-TB patients should be intervened earlier:including health education,effective protection and health examination regularly et al.
7.Changes of body weight, blood glucose in chronic intermittent hypoxic rats and protection of iptakalim.
Hong SHEN ; Wei-ping XIE ; Hong WANG ; Ya-qin ZHAI ; Jian-kang CAI
Chinese Journal of Applied Physiology 2010;26(2):215-248
Animals
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Blood Glucose
;
drug effects
;
Body Weight
;
drug effects
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Chronic Disease
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Female
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Hypoxia
;
physiopathology
;
KATP Channels
;
drug effects
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Male
;
Propylamines
;
pharmacology
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Protective Agents
;
pharmacology
;
Rats
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Rats, Sprague-Dawley
8.Study of infection of Echinococcus granulosus in yak in spring and its potential role in transmission of cystic Echinococcosis in Rangtang County of Sichuan, China.
Huan Huan HU ; Wei Ping WU ; Li Ying WANG ; Qian WANG ; Yan HUANG ; Ya Yi GUAN
Biomedical and Environmental Sciences 2013;26(3):226-229
Animals
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Cattle
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China
;
epidemiology
;
Echinococcosis
;
epidemiology
;
parasitology
;
transmission
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Echinococcus granulosus
;
pathogenicity
;
Humans
;
Seasons
9.Synergetic effect of flue gases and arsenic on DNA injury in lymphocytes.
Yi WANG ; Chun-wei LU ; Lu WANG ; Ya-ping JIN ; Yuan-yuan XU ; Gui-fan SUN
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(3):175-177
Animals
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Arsenic
;
toxicity
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Comet Assay
;
DNA Damage
;
drug effects
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Lymphocytes
;
drug effects
;
metabolism
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Male
;
Malondialdehyde
;
metabolism
;
Rats
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Rats, Wistar
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Tobacco Smoke Pollution
;
adverse effects
10.Effect of SIRT6/NF-κB signal axis in delaying hematopoietic stem/progenitor cell senescence with ginsenoside Rg1.
Yue ZHOU ; Yan-long TANG ; Ya-ping WANG ; Jian-wei WANG ; Ji-chao DING
China Journal of Chinese Materia Medica 2015;40(3):511-515
OBJECTIVETo investigate the effect of SIRT6/NF-κB signal axis in delaying hematopoietic stem/progenitor cell senescence with ginsenoside Rg1, in order to provide theatrical and experimental basis for looking for methods for delaying HSC senescence.
METHODSca-1 + HSC/HPC was isolated by magnetic cell sorting (MACS) and divided into five groups: the normal control group, the aging group, the positive control group, the Rg1 anti-senescence group, and the Rg1-treated group. Senescence-associated β-galactosidase (SA-β-Gal) staining, cell cycle analysis and hemopoietic progenitor cell mix (CFU-Mix) were adopted to determine the effect Rg1 in delaying or treating Sca-1 + HSC/HPC senescence biology. The mRNA and protein of senescence regulation molecules SIRT6 and NF-KB were examined by realtime fluorescence quantitative PCR (FQ-PCR) and western blotting.
RESULTCompared with the senescence group, the Rg1 anti-senescence group and the Rg1-treated group showed lower percentage in SA-β-Gal-stained positive cells, decreased cell proportion in G1 phase, increased number of CFU-Mix, up-regulated in SIRT6 mRNA and protein expression, down-regulation in NF-KB mRNA and protein expression. The Rg1 anti-senescence group showed more evident changes in indexes than the Rg1-treated group.
CONCLUSIONRg, may inhibit Sca-1 + HSC/HPC senescence induced by t-BHP by regulating SIRT6/NF-KB signal path.
Animals ; Antigens, Ly ; analysis ; Cellular Senescence ; drug effects ; Female ; Ginsenosides ; pharmacology ; Hematopoietic Stem Cells ; drug effects ; Male ; Membrane Proteins ; analysis ; Mice ; Mice, Inbred C57BL ; NF-kappa B ; physiology ; Signal Transduction ; physiology ; Sirtuins ; physiology