2.Hope for the patients with retinitis pigmentosa
Wei-jing, YIN ; Li-ya, WANG ; Wei, WANG ; Feng, PAN
Chinese Journal of Experimental Ophthalmology 2011;29(2):97-100
Retinitis pigmentosa (RP) is a hereditary disease characterized by the progressive loss of photoreceptor cells. Disease pathology primarily affects rod photoreceptor cells first but light-insensitive cone photoreceptor bodies can survivor longer. Delivered by adeno-associated viral vector or lentiviral vector, expression of microbial-type rhodopsin, channelrhodopsin-2 or archaebacterial halorhodopsin in the survived retinal cells can substitute for the native phototransduction cascade in mouse models of retinitis pigmentosa. It can also restore light sensitivity and activate all retinal cone pathways and drive sophisticated retinal circuit functions. Thus, expression of channelrhodopsins or halorhodopsin might be a potential strategy for the restoration vision of patients with RP.
3.The periodontal initial therapy on chronic periodontics with periodontal-endodontic lesion: a case report.
Hong-yan WANG ; Li-si TAN ; Jing-bo LIU ; Ya-ping PAN
Chinese Journal of Stomatology 2013;48(12):755-758
Chronic Periodontitis
;
complications
;
diagnosis
;
diagnostic imaging
;
therapy
;
Dental Pulp Diseases
;
complications
;
diagnosis
;
diagnostic imaging
;
therapy
;
Dental Scaling
;
Female
;
Humans
;
Periodontal Debridement
;
Periodontal Diseases
;
complications
;
diagnosis
;
diagnostic imaging
;
therapy
;
Radiography
;
Root Canal Therapy
;
Root Planing
;
Young Adult
4.Evaluation of the follow up results of patients with cervical intraepithelial neoplasia Ⅲ after surgical treatment
Zhi-Qin DAI ; Ling-Ya PAN ; Hui-Fang HUANG ; Jing-He LANG ;
Chinese Journal of Obstetrics and Gynecology 2001;0(02):-
Objective To evaluate the follow-up results of patients with cervical intraepithelial neoplasia Ⅲ(CIN Ⅲ)after surgical treatment.Methods A retrospective analysis of consecutive patients with CIN Ⅲ after surgical treatment between Jan 1st,1999 and Jun 30 th,2004 was performed.The follow- ups of the patients after surgical treatment were assessed.Results In the follow-up of patients with CINⅢ after surgical treatment,the rate of abnormal cytology was 9.3%.The rate of follow-up was higher in patients with cervical conization than in patients with initial hysterectomy and in patients of the oncological group than of the non-oncological group.The rate of follow-up was lower in patients over 40 years old.There was no difference in the residential areas of the patients.Conclusions Cytological follow-up of patients with CINⅢ after operation is varied.The rate of follow-up is lower in patients over 40 years old,in patients having initial hysterectomy and in patients of the non-oncological group.The rate of follow-up is associated with the knowledge about CIN of both surgeons and patients.
5.Clinical analysis of the effect of cervical conization on fertility and pregnancy outcome
Haojie HE ; Ling-Ya PAN ; Hui-Fang HUANG ; Jing-He LANG ;
Chinese Journal of Obstetrics and Gynecology 2001;0(08):-
0.05).Among the 26 pregnancies,there occurred one ectopic pregnancy and four cases of spontaneous abortion.In the 13 delivery cases,there were one premature delivery,two cases of premature rupture of the membrane,and ten cases of cesarean section.The sample height of the cone was less than 2.0 cm in the nine delivery cases,and the mean width of the cone was over 2.5 cm.Conclusion No evidence of secondary infertility caused by cervical conization was found.There was also no significant increase in the number of either premature delivery cases or low birth weight infants. The sample height of the cone might play a more important role in the pregnancy outcome than the width, which still needs to be further verified by larger studies.
6.Comparison between percutaneous dilational tracheotomy and surgical tracheotomy.
Jian-Guo XU ; Xin-Guo CHEN ; Ya-Jing PAN
Chinese Journal of Otorhinolaryngology Head and Neck Surgery 2007;42(11):869-870
Adolescent
;
Adult
;
Aged
;
Aged, 80 and over
;
Female
;
Humans
;
Male
;
Middle Aged
;
Tracheotomy
;
methods
;
Young Adult
7.A comparison study of the clinical features between Chinese and Indian primary congenital glaucoma patients
Mao, LI ; Xiao-Ming, CHEN ; Ya-Li, LIU ; Ru-Gang, PAN ; Dong-Jing, LIU ; Ni, LI
International Eye Science 2006;6(2):282-290
· AIM: To summarize the clinical features of Chinese primary congenital glaucoma and to investigate the discrepancies of the clinical features between the Chinese and Indian patients.congenital glaucoma patients were reviewed. The clinical features were summarized as several quantifiable clinical parameters and the severity of the disease was evaluated. Both the quantified clinical features and severity were statistically compared with those of the Indian patients, which were cited from the previous published articles.included in the study. In Chinese patients, sex ratio (male to female )was about 2:1, family history was presented in 3 patients (7.5%) and consanguinity was found in one patient (2.5%). The main symptoms and signs observed in Chinese patients spanned a wide spectrum of manifestations. The most frequent signs noted on the initial examination were enlarged eyeball (42.5%) and decreased visual acuity (35.0%). Compared with Indian patients, Chinese patients had a later onset, a delayed diagnosis, more severe corneal changes and more severe optic nerve damages (P<0.01). The combined tabeculectomy and trabeculotomy operation was preferred by both Chinese and Indian doctors whereas a higher proportion of Indian patients received the combined operation (P<0.01). The proportions of the severity grade were different between Chinese and Indian patients. Most Chinese patients were in the severe grade while most Indian patients were in the very severe grade (P<0.01).patients were sporadic and non-consanguineous.Compared with Indian patients, Chinese patients had a relative later onset, a delayed diagnosis and treatment.More attempts are needed in Chinese PCG prevention and treatment.
8.A survey on the periodontal status in type 2 diabetic patients.
Jian-quan ZHANG ; Ya-ping PAN ; Li MA ; Li-si TAN ; Jing-bo LIU ; Jing-jing WEI
Chinese Journal of Stomatology 2009;44(11):668-671
OBJECTIVETo investigate the type 2 diabetic patient's periodontal condition and to analyze the influencing factors of periodontitis.
METHODSA total of 182 type 2 diabetic patients were included in the survey and requested to fill out a questionnaire, and their periodontal status was evaluated by measuring probing depth (PD), attachment level (AL), sulcus bleeding index (SBI), simplified oral hygiene index (OHI-S).
RESULTSThe prevalence of periodontitis in this group of patients was 96.7% (176/182), including 20 patients with mild periodontitis, 156 with moderate to advanced periodontitis. The mean PD and AL of the 182 patients were (2.92 +/- 0.67) mm and (2.87 +/- 1.31) mm. At least one tooth was lost in 57.1% (104/182) of the patients. The factors related to periodontitis were age, gender, smoking, living in town or country, and 2 h plasma glucose of oral glucose tolerance test (OGTT). There was no relationship between the severity of periodontitis and education level. The majority of patients did not receive any periodontal therapy.
CONCLUSIONSPeriodontal status was bad in patients with type 2 diabetes. It is important to develop an education program on oral health for type 2 diabetic patients.
Aged ; Diabetes Mellitus, Type 2 ; complications ; Educational Status ; Humans ; Periodontal Diseases ; Periodontal Index ; Periodontitis ; diagnosis ; epidemiology ; Prevalence ; Rural Population ; statistics & numerical data ; Surveys and Questionnaires ; Urban Population ; statistics & numerical data
9.Screening of lipoprotein genes of Porphyromonas gingivalis in chronic periodontitis patients.
Li LIN ; Jing-bo LIU ; Chen LI ; Ya-ping PAN
Chinese Journal of Stomatology 2010;45(4):207-210
OBJECTIVETo screen PG0717, PG0183 and PG2135 gene of Porphyromonas gingivalis (Pg) in subgingival plaque of the chronic periodontitis patients and periodontally healthy subjects and to investigate the relationship of these genes and periodontal clinical parameters.
METHODSForty-one chronic periodontitis patients and 76 periodontally healthy individuals were included. Clinical parameters were measured and recorded by a single examiner, which included bleeding on probing (BOP), attachment loss (AL), probing depth (PD), and tooth mobility (TM). Subgingival plaque samples were taken by sterile subgingival curette. The three genes, which were present in PgW83 but absent from PgATCC33277 were labeled with Cy5 and used as probes in DNA microarray hybridization. The PG0717, PG0183 and PG2135 gene in affected region, normal region and healthy individuals of Pg was examined.
RESULTSThe detecting rate of PG0717, PG0183 and PG2135 was 90% (18/20), 70% (14/20) and 70% (14/20) respectively in affected region, 60% (12/20), 45% (19/20) and 40% (8/20) respectively in normal region and 55% (11/20), 25% (5/20), 30% (6/20) in Pg of healthy individuals. The detecting rate of PG0717, PG0183 and PG2135 was significantly different between the affected region and the healthy individuals (P < 0.05).
CONCLUSIONSThe Pg with genes of PG0717, PG0183, PG2135 was more pathogenic.
Adolescent ; Adult ; Aged ; Chronic Periodontitis ; microbiology ; Female ; Gene Expression Regulation, Bacterial ; Genes, Bacterial ; Gingiva ; microbiology ; Humans ; Lipoproteins ; genetics ; metabolism ; Male ; Middle Aged ; Porphyromonas gingivalis ; genetics ; isolation & purification ; Young Adult
10.High performance thin layer chromatography quality assessment of Rogor, methyl parathion, methamidophos and dichlorvos in serum.
Hui-fang YAN ; Ya-juan PAN ; Jian WANG ; Fu-gang ZHANG ; Xiao-shuang XIE ; Jing ZHANG ; Chun-ling LI
Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(7):437-438
Animals
;
Chromatography, Thin Layer
;
Dichlorvos
;
blood
;
Dimethoate
;
blood
;
Insecticides
;
blood
;
Methyl Parathion
;
blood
;
Mice
;
Organothiophosphorus Compounds
;
blood