2.Extraction Technology Optimization for Yushaoshang Liposomal Gels by Orthogonal Test
Weiqiong REN ; Rong OUYANG ; Ya LI ; Shan LI
China Pharmacist 2015;(1):20-22
Objective:To optimize the conditions in the extraction process of Yushaoshang liposomal gels. Methods: Using the content of hydrobererine and extract yield as the indices, the optimum extraction conditions were screened by orthogonal test. Results:The optimum extraction conditions were as follows:Rhizoma coptidis was crashed into small particles as 10 mesh sieve, heating extrac-ted three times with 10-fold,8-fold and 8-fold water, and extracting 3h, 2h and 2h,respectively. Conclusion:The extraction technology is reliable and available in the preparation of Yushaoshang liposomal gels.
3.Congenital left ventricular diverticulum diagnosed by echocardiography.
Yan SUN ; Rong-Juan LI ; Jun XUE ; Ya YANG
Chinese Medical Journal 2013;126(6):1137-1137
Adult
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Diverticulum
;
complications
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Echocardiography
;
methods
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Heart Diseases
;
diagnosis
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Heart Ventricles
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pathology
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Humans
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Male
;
Young Adult
4.Cost-effectiveness of integrated pharmaceutical care in community-based patients with chronic obstructive pulmonary disease
Zongjun FANG ; Zhen LI ; Mingjian GE ; Rong YANG ; Ya ZHU
Chinese Journal of General Practitioners 2012;(7):507-510
Objective To analyze the cost-effectiveness of integrated pharmaceutical care (IPC) in community-based patients with chronic obstructive pulmonary disease (COPD).Methods The COPD patients were divided randomly into intervention group (group A,n =79) and control group (group B,n =71).Group A received the IPC intervention measures,including serial lectures of pharmaceutical knowledge,home supervision and web-based communications for while group B group had none.Results As compared with group B,group A obviously improved on the knowledge of pharmaceutical treatment effect and side effect (95.1%,67.4% vs.63.1%,21.9%,x2 =12.445,P=0.000 vs.x2 =55.557,P=0.000).There were notable differences between two groups [ ( 1.77 ± 1.23 ) vs.( 2.42 ± 1.66 ) s,t =2.583,P=0.011],pulmonary rales [ (0.01 vs.0.01)s,Z =2.370,P=0.018],6-min walk distance (6 MWD) [ (457 ± 67 ) vs.(425 ± 72) m,t =2.760,P =0.007 ],vital capacity ( VC ) [ ( 1.60 ± 0.25 ) vs.( 1.49 ± 0.23 ) L,t =2.718,P =0.007 ) ] andquality-of-life items ( 48 ± 10 vs.52 ± 11,t =2.624,P =0.010) after intervention.Analyze of cost-effectiveness show that groupA was superior to group B [ total effect total cost(TE/TC =764.6/4936,15.49% )vs.(TE/TC =1509.4/4708),32.06%,x2 =6.183,P < 0.01 ].Conclusion IPC can improve the disease condition and achieve excellent cost-effectiveness for community-based COPD patients.
6.Relationship between Ulcerative Colitis and Lung Injuries.
Zhi-peng TANG ; Jia-wei WU ; Yan-cheng DAI ; Ya-li ZHANG ; Rong-rong BI
Chinese Medical Sciences Journal 2015;30(2):65-69
OBJECTIVETo explore the relationship between ulcerative colitis (UC) and lung injuries by assessing their clinical manifestations and characteristics.
METHODSFrom July 2009 to April 2012, 91 UC patients presenting to Longhua Hospital who met the established inclusion and exclusion criteria were enrolled in this retrospective study. According to the scores of disease activity index, the patients were divided into the mild, moderate, and severe groups. Meanwhile, the records of pulmonary symptoms, chest X-ray image, and pulmonary function were reviewed.
RESULTSSixty-eight (74.7%) patients had at least 1 pulmonary symptom, such as cough (38.5%), shortness of breath (27.5%), and expectoration (17.6%). And 77 (84.6%) had at least 1 ventilation abnormality. Vital capacity value was significantly lower in the severe group than that in the mild group (91.82%±10.38% vs. 98.92%±12.12%, P<0.05).
CONCLUSIONSLung injury is a common extraintestinal complication of UC. According to the theory in Traditional Chinese Medicine that the lung and large intestine are related, both the lungs and large intestine should be treated simultaneously.
Adult ; Colitis, Ulcerative ; complications ; physiopathology ; Female ; Humans ; Lung Injury ; etiology ; Male ; Middle Aged ; Vital Capacity
7.Primary small cell carcinoma of the breast: report of a case.
Li-mei QU ; Gang ZHAO ; Ya-bin ZOU ; Yu-E SONG ; Li-rong BI
Chinese Journal of Pathology 2011;40(2):120-121
Aged
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Breast Neoplasms
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metabolism
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pathology
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surgery
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Cadherins
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metabolism
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Carcinoma, Merkel Cell
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metabolism
;
pathology
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Carcinoma, Small Cell
;
metabolism
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pathology
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surgery
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Diagnosis, Differential
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Female
;
Humans
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Lymphoma
;
metabolism
;
pathology
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Melanoma
;
metabolism
;
pathology
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Phosphopyruvate Hydratase
;
metabolism
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Synaptophysin
;
metabolism
8.Effect of American Ginseng Capsule on the liver oxidative injury and the Nrf2 protein expression in rats exposed by electromagnetic radiation of frequency of cell phone.
Ya-ping LUO ; Hui-Rong MA ; Jing-Wei CHEN ; Jing-Jing LI ; Chun-xiang LI
Chinese Journal of Integrated Traditional and Western Medicine 2014;34(5):575-580
OBJECTIVETo observe the effect of American Ginseng Capsule (AGC) on the liver oxidative injury and the Nrf2 protein expression in the liver tissue of rats exposed by 900 MHz cell phone electromagnetic radiation.
METHODSTotally 40 male SD rats were randomly divided into the normal control group, the model group, the Shuifei Jibin Capsule (SJC) group, and the AGC group,10 in each group. Rats in the normal control group were not irradiated. Rats in the rest three groups were exposed by imitated 900 MHz cellular phone for 4 h in 12 consecutive days. Meanwhile, rats in the SJC group and the AGC group were intragastrically administrated with suspension of SJC and AGC (1 mL/200 g body weight) respectively. Normal saline was administered to rats in the normal control group and the model group. The histolomorphological changes of the liver tissue were observed by HE staining. Contents of malonic dialdehyde (MDA), superoxide dismutase (SOD), glutathione (GSH), and glutathione peroxidase (GSH-PX)were detected by colorimetry. The Nrf2 protein expression of hepatocytes was detected by immunohistochemical assay and Western blot.
RESULTSCompared with the normal control group, hepatocyte nucleus was atrophied or partially disappeared, the contents of liver MDA and Nrf2 protein obviously increased (P <0. 05, P <0. 01); contents of liver SOD and GSH decreased (P <0. 05) in the model group. Compared with the model group, karyopyknosis was obviously attenuated and approached to the normal level in the SJC group and the AGC group. The contents of liver MDA and Nrf2 protein expression decreased (P <0. 05), and the contents of liver SOD, GSH, and GSH-PX obviously increased (P < 0.05) in the SJC group. The contents of liver MDA and the Nrf2 protein expression decreased (P < 0.05), and contents of SOD and GSH obviously increased in the AGC group (P <0.01, P <0.05).
CONCLUSIONSThe electromagnetic radiation induced by 900 MHz cell phone could affect the expression of Nrf2 protein, induce oxidative injury, and induce abnormal morphology of liver cells. SJC and AGC could promote the morphological recovery of the liver cells. Its mechanism might be related to affecting the expression of Nrf2 protein and attenuating oxidative damage of liver cells.
Animals ; Cell Phone ; Electromagnetic Radiation ; Glutathione Peroxidase ; metabolism ; Hepatocytes ; metabolism ; Liver ; Male ; NF-E2-Related Factor 2 ; metabolism ; Oxidative Stress ; drug effects ; Panax ; Plant Extracts ; pharmacology ; Rats ; Superoxide Dismutase ; metabolism
10.Comparative analysis of seven marine biological source of mineral drugs.
Wei SI ; Ru-na A ; Shang-rong LI ; Jing-Xian ZHANG ; Wan-ying WU ; Ya-jun CUI
China Journal of Chinese Materia Medica 2014;39(17):3321-3325
The marine biological source of mineral drugs recorded in Chinese Pharmacopoeia (2010 version) mainly including pearl, nacre, clam shell, common oyster shell, ark shell, cuttle bone, and sea-ear shell are widely used in clinical. Calcium carbonate and a small amount of protein are the main components in this type of drugs. In this paper, a systematical and comparable study were carried out by determination of calcium carbonate by EDTA titration method, the crystal of calcium carbonate by X-Ray powder diffraction and the total amino acids (TAAs) of the hydrolyzed samples by ultraviolet spectrophotometry method. As a result, the crystal structure is calcite for common oyster shell, mixture of calcite and aragonite for nacre and sea-ear shell, aragonite for the other drugs. The content of calcium carbonate ranged from 86% to 96%. Cuttle bone has the highest amount of TAAs among the seven drugs which reached 1.7% while clam shell has the lowest content of 0.16% on average. In conclusion, an effective method was developed for the quality control of marine mineral drugs by comprehensive analysis of calcium carbonate and TAAs in the seven marine mineral drugs.
Amino Acids
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analysis
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chemistry
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Animal Shells
;
chemistry
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Animals
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Calcium Carbonate
;
analysis
;
chemistry
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Crystallization
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Edetic Acid
;
chemistry
;
Mollusca
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chemistry
;
classification
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Pharmaceutical Preparations
;
analysis
;
chemistry
;
standards
;
Quality Control
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Reproducibility of Results
;
Seawater
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Species Specificity
;
Spectrophotometry, Ultraviolet
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X-Ray Diffraction