AIM: To study central corneal thickness ( CCT ) and correlation in different degrees of diabetic retinopathy ( DR) .
METHODS:A total of 65 cases (130 eyes) with different degrees of DR and 35 normal cases (70 eyes) as the age-and gender-matched control group were examined by corneal endothelial microscope, to measure CCT and statistics
RESULTS: Compared to control group, there were no significant difference of CCT both mild and medium nonproliferative diabetic retinopathy ( NPDR) groups ( P>0. 05 ). While the CCT of severe NPDR group and proliferative diabetic retinopathy ( PDR ) group were thicker than control group, and the differences were statistically significant (P<0. 05); Pairwise comparison in different degrees of DR groups: the CCT of severe NPDR and mild NPDR groups were thicker than PDR group, and the differences were statistically significant ( P<0. 05 );compared to medium NPDR, the CCT of PDR was thicker (P<0. 05);The thickness of CCT increases with severity of DR, there was positive linear correlation ( r=0. 173, P<0-05).
CONCLUSION: The CCT increases with severity of DR. Taking care of protecting corneal endothelium is very important in the time of therapeutic measure, especially intraocular operation, to decrease complication.

Humans ; Osteoporosis ; drug therapy ; Technetium Tc 99m Medronate ; therapeutic use

Objective: To evaluate the protective effect of δ-opioid peptide, [D-Ala2-D Leu5]-enkephaline (DADLE), on pulmonary ischemia-reperfusion (I-R) injury after cardiopulmonary bypass (CPB), and to discuss the possible mechanism. Methods: Twenty-eight male pigs were evenly randomized divided into 4 groups, namely, the sham operation group, the CPB group (only subjected to CPB), the DADLE pretreatment group (received DADLE 1 mg · kg-1 before CPB), and the Glibenclamide group (received DADLE 1 mg · kg-1 and glibenclamide 1 mg · kg-1 before CPB). Peak inspiratory pressure (PIP), PaO2, and the plasma malondialdehyde (MDA) concentration were measured in each group before CPB and 10 min, 30 min, and 60 min after reperfusion. The changes of lung tissue wet weight/dry weight ratio (W/ D) were calculated before CPB and 60 min after reperfusion. The animals were sacrificed 60 min after reperfusion to observe the ultrastructural changes of the lungs and to quantitatively assess lung tissue damage (LTD). Results: There were no significant differences among the 4 groups before CPB and the parameters in sham-operation group had no changes at all specified time points. One hour after reperfusion, the PIP, MDA, W/D, and LTD values in Glibenclamide and CPB groups were significantly higher than those in sham-operation and DADLE groups while the PaO2 was significantly lower(P<0.05 or 0.01). There were no significant differences between parameters of sham-operation and DADLE groups except for LTD(P<0.05). There were no significant differences between parameters of Glibenclamide and CPB groups. Histological examination demonstrated that the degree of lung injuries in sham-operation and DADLE groups were slighter than those in Glibenclamide and CPB groups. Conclusion: It suggests that DADLE may exert its protective effect on the lung through opening ATP-sensitive K+ channels, so as to alleviate the lung I-R injury after CPB.

Humans ; Vascular Diseases ; surgery

Objective: To study the distributions of velocity, wall pressure and wall shear stress of blood flow in the human thoracic aorta under normal physiological pulsatile flow conditions, so as to provide a theoretical foundation for elucidating the pathogenesis of aortic dissection. Methods: By virtue of the Computational Fluid Dynamics and the fundamentals of hemodynamics, the authors obtained the numerical simulations and flow visualizations of pulsating blood flow in the human thoraric aorta. Results: The distributions of velocity, wall pressure, wall shear stress and path line of the blood flow in the thoracic aorta were calculated with a function of time in the cardiac circle. The systoltic wall pressure and its dp/dt were higher than diastolic wall pressure and its dp/dt. The pressure of lateral wall was higher than the pressure of medial wall during systole. A distinct depressed pressure was found located at the intersection between aortic arch and descending aorta. Shear stress of wall of lateral aortic arch was less than that of medial wall of aortic arch and the shear stress change in medial wall of aortic arch was greater than that in the lateral aortic wall. The shear stress was in a cyclic and alternative manner. Conclusion: The findings suggest that the wall pressure may be related to the development of aortic dissection.

Language ; Medicine, Chinese Traditional ; Terminology as Topic ; Translations

Aged ; Chondrosarcoma ; Humans ; Laryngeal Neoplasms ; Male ; Middle Aged

Diagnosis, Differential ; Genital Neoplasms, Male ; metabolism ; pathology ; surgery ; Humans ; Male ; Middle Aged ; Neoplasms, Glandular and Epithelial ; metabolism ; pathology ; surgery ; Neprilysin ; metabolism ; Receptors, Estrogen ; metabolism ; Receptors, Progesterone ; metabolism ; Seminal Vesicles ; Stromal Cells ; pathology ; Vimentin ; metabolism

Actins ; metabolism ; Adult ; Amyloidosis ; pathology ; Diagnosis, Differential ; Female ; Humans ; Intestinal Pseudo-Obstruction ; metabolism ; pathology ; Lupus Erythematosus, Systemic ; pathology ; Muscular Atrophy ; pathology ; Scleroderma, Systemic ; pathology ; Young Adult

BACKGROUND: There have been reports about the cochlea injury after high-velocity projectile wounding. The effect on ultrastructure of cochlea after blast was still unclear.OBJECTIVE: To investigate ultrastructural changes of cochlea and cochlear nerve after maxillofacial blast wound.DESIGN:A randomized controlled observational trail with dogs as subjects.SETTING: Otolaryngeal Department and Maxillofacial Surgery Laboratory of the Third Military Medical University of Chinese PLA.MATERIALS: The study was conducted from August 1995 through July 1997. The animal model in maxillofacial blast wound was established in Animal Center of Xinqiao Hospital of the Third Military Medical University of Chinese PLA. Specimens were treated in Maxillofacial Laboratory and observed in Electron Microscope Laboratory. Totally 15 dogs of either sex (weighting 9. 5 - 13.5 kg, mean 11.3 kg ) were randomly divided into three groups with 5 in each group. Two groups served as trauma groups 1 and 2 and the other group as control.METHODS: The maxillary and mandibular regions of 10 dogs in trauma groups were wounded by model 8 cardboard-shelled detonators to establish animal model of maxillofacial blast wound. At the 1st and 6th hour after trauma the wounds were examined and specimens of cochlea and cochlear nerve were dissected out for electron microscopic observation to study the ultrastructural changes. The specimens in the control group were treated the same way as those in the trauma groups except for blast injury.RESULTS: After wounded, the cochlea and cochlear nerve in the early period manifested cilia disorder, edema of the nerve and mitochondrial degeneration. At the 6th hour after trauma there were extensive degeneration in cochlea and cochlear nerve, cilia fallen off hair cells and dissolution of the structures in nerve sheath.CONCLUSION: The ultrastructural changes of cochlea and cochlear nerve are severed as a result of maxillofacial blast wound, but in early period the injury is reversible. So it is very important that early cure should be emphasized in treatment.