Sepsis is one of common diseases in pediatrics,critically ill children tend to suffer multiple organ damage that will increase children's risk of death.Hyperglycemia is an important symbol of metabolic disorder after onset of sepsis,with the deepening of understanding that sepsis can cause the pancreatic damage.Therefore,not all hyperglycemia is a representation of transient or stress state.To control hyperglycemia of sepsis in children can help to reduce their complications and mortality.In this review,it will deal with the occurrence of sepsis in children with blood glucose disturbance,regulation and prognosis.