OBJECTIVE:To investigate the method for preparation and quality control of ornidazole oral membrane.METHODS:Ornidazole oral membrane was prepared with polyvinyl alcohol and sodium carboxymethylcellulose as its adju-vants;The content of ornidazole was determined by ultraviolet spectrophotometry at the wavelength of316nm.RESULTS:There was a good linear correlation within a range of6.0～18.0?g/ml(r=0.9997)of ornidazole concentration,the average recovery was100.19%(RSD=0.66%,n=5).CONCLUSION:The established technique is simple,and the content deter-mination is quick,precise and reliable.

The paper elabrates the function of bibliographic management software in either managing literatures or writing papers, as well as the noted problems of college and university libraries carrying out bibliographic management software training. It also points out the importance of the software application in medical information literacy education.

Objective Evaluation of enema application of Yiyi-Fuzi-Baijiang powder combined with oral sulfasalazine enteric-coated tablets in treating ulcerative colitis. Methods The patients with ulcerative colitis were randomly divided into 2 groups, 42 cases in each group. The control group was treated with sulfasalazine, and the observation group with sulfasalazine and Yiyi-Fuzi-Baijiang powder. Both groups were treated for 4 weeks. ELISA method was used to detect the levels of IL-6, IL-8 and TNF-α. The changes of disease activity index (Sutherland DAI) were observed before and after treatment, and the clinical efficacy was evaluated. Results After treatment, the Sutherland DAI (3.89 ± 0.91 vs. 4.91 ± 1.08, t=3.082) in the observation group was significantly lower than that in the control group (P=0.042). The level of TNF-α (20.82 ± 4.31 ng/L vs. 26.51 ± 5.25 ng/L, t=3.602), IL-6 (31.73 ± 4.82 ng/L vs. 40.18 ± 5.63 ng/L, t=3.817), and IL-8 (35.39 ± 4.62 ng/L vs. 40.59 ± 5.35 ng/L, t=3.341) in the observation group were significantly lower than those in the control group (P<0.05). The total efficiency of observation group was 92.9% (39/42), and the control group was 73.8% (31/42). There was significant difference between the two groups (χ2=4.200, P=0.040). Conclusions The Yiyi-Fuzi-Baijiang powder combined with sulfasalazine could relieve the clinical symptoms of ulcerative colitis patients with spleen-kidney yang deficiency, and inhibition inflammatory response.

Planar cell polarity pathway regulates cell polarity and polarized cell movements.Recent studies in mouse models have found mutations in several genes in this pathway and specifically in the Vangl2 gene,which results in abnormalities in cardiac development,suggesting Vangl2 and this pathway play an important role in heart development.This review mainly elucidates the mechanisms regulated by the Vangl2 gene and PCP pathway during outflow tract development and the formation of the coronary vasculature.

AlM: To establish the frequency, associations and risk factors for age-related macular degeneration ( AMD ) in hospital population.
METHODS: ln this hospital based study, 589 subjects above 60 years of age were screened randomly for AMD. Participants underwent ocular evaluation and were interviewed for lifestyle variables and dietary intake of carotenoids by structured food frequency questionnaire. AMD was defined according to the international classifications and grading system.
RESULTS: Either form of AMD was detected in 48 participants. AMD was significant among diabetes, diabetic retinopathy, body mass index, heavy cigarette smokers and alcoholics ( P < 0. 05 ). Dietary lutein/zeaxanthin ( L/Z) and β-carotene intake were associated with the reduction in risk for AMD(P<0. 05).
CONCLUSlON: Higher dietary intake of carotenoids, especially L/Z, is associated with lower risk for AMD. Risk of AMD is prevalent among subjects with diabetes. Cessation of smoking and alcohol may reduce the risk of AMD in this population.

Objective To introduce a patent: The assembled equipment of external counterpulsation with an oxygen mask in the treatment of ischemic diseases that has been opened by the national property right bureau of knowledge.Methods Based on the current equipment,oxygen was provided with a mask along with external counterpulsation.Results It could enhance blood stream as well as the blood oxygen rate.Conclusion Assembled equipment of external counterpulsation with oxygen mask can enhance cure speed and rate in the treatment of ischemic diseases.

Objective: Thyroid nodules are common clinical thyroid disorders.The purpose of this study was to investigate the diagnostic value of the clinical characteristics and various parameters of malignant thyroid nodules and the sensitive indexes for their differentiation so as to improve the diagnosis of malignant thyroid nodules and avoid unnecessary procedures or operations.Methods: We retrospectively studied 600 cases of thyroid nodules treated by surgery from 2001 to 2008,divided them into a benign and a malignant group according to the pathological results,and analyzed by multivariate logistic regression the correlation between the nature of thyroid nodules and various factors.Results: Of the 600 cases of thyroid nodules,519(83.47%) were benign and 81(16.53%) were malignant.Clinical symptoms and signs,ultrasonography and CT were all useful in indicating malignancy,especially ultrasonography,whose specificity and diagnostic accuracy were 93.3% and 84.2%,respectively.Multivariate logistic regression analysis revealed a higher rate of malignancy in younger patients with solid or hard nodules,or accompanied with calcification or painless adenophyma in the neck.Conclusion: Clinical symptoms and signs,ultrosonography and CT are of significant value in the diagnosis of malignant thyroid nodules.

OBJECTIVE:To discuss the disposal of essential oil in the preparation process of solid preparations containing Ligusticum chuanxiong and Angelica dahurica.METHODS:Based on pertinent literature in recent years,the disposal of essential oil in the preparation process of solid preparations containing Ligusticum chuanxiong and Angelica dahurica was discussed from aspects of chemical components,pharmacology and extraction process etc.RESULTS & CONCLUSION:It is necessary to combine research on preparation process with the pharmacological effect and pharmacodynamic action,and to formulate effective measures to control quality of the essential oil during the whole preparation process to facilitate a solution for the disposal of essential oil.

This is a review of recent progress in the study on environment sensitive hydrogel based on cyclodextrin and their most recent and relevant applications in the intelligent drug delivery systems. Based on relevant literatures, the development of environment sensitive hydrogel responsive to physical, chemical and biochemical stimuli was introduced, involving their categorization, design principles, mechanism of action and potential application. Various new types of intelligent drug delivery system, which responds to various triggers, could be constructed by using the cyclodextrin-based environment sensitive hydrogel. They made it possible to control the drug release freely. Although these hydrogels are still at their research stage, they have attracted considerable interest in the intelligent drug delivery system.