The treatment of relapsed and refractory multiple myeloma has always been a problem among hematologic malignant tumor treatment.Compared with the initial therapy,there are worse therapeutic effects and more affecting factors of selecting treatment since the existence of drug resistance in relapsed myeloma.In this review,the therapeutic effects of single and combinational use of several novel agents such as thalidomide,lenalidomide and bortezomib were evaluated in treating relapsed and refractory multiple myeloma.The clinical results of some new anti-myeloma agents were also reported.

The incidence of venous thromboembolism (VTE) in multiple myeloma patients is higher than that of normal population. In this review, recent advances about thrombosis in multiple myeloma are studied,including the mechanism,risk factors,therapy and prevention of thrombosis.

BACKGROUND: Schwann cells are the only glial cells in the peripheral nervous system and play an important role in the regeneration of peripheral nerves, while they have poor proliferation capacity and decreased activity, need allografts, and are difficult to culture in vitro. OBJECTIVE: To analyze the feasibility of repairing neurologic defects with tissue-engineered nerves constructed with Schwann cells derived from bone marrow stromal stem cells. DESIGN, TIME AND SETTING: Randomized controlled observation was conducted at Heilongiiang Institute of Veterinary Pharmaceutics between March 2004 and April 2005.MATERIALS: Twenty-four 8-weck-old female Wistar rats were used to establish animal models with 10 nun defect of sciatic nerve. METHODS: Twenty-four rats were divided into 3 groups by random digits table, tissue-engineered nerve group, polylactic acid robe group and autologons nerve group, with 8 rats in each group. Tissue-engineered nerve group: tissue-engineered nerve Was used to bridge neurologic defect, which was constructed with Schwann cells derived from bone marrow stromal stem cells, natural extracelhilar matrix gel and degradable polylactic acid tube. Polylactic acid robe group: injecting extracellular matrix gel into degradable polylactic acid tube to bridge neurologic defect. Autologous nerve group: 10 mm of nerve was cut and performed end-to-end anastomosis after revolving 180 degrees. MAIN OUTCOME MEASURES: Functional recovery of sciatic nerve was detected with electrophysiological observation of nerve, and histological observation and axon count of the newly generated nerve tissue at 12 weeks after transplantation. RESULTS: After introduction, adult bone marrow stromal stem cells had the morphology and properties of Schwann cells. The regenerated nerve had grown to the distal end passing through the defect at 12 weeks after transplantation. The detection indexes in the tissue-engineered nerve group and autologous nerve group were better than that in the polylactic acid tube group (P < 0.05), there were no significant differences between the tissue-engineered nerve group and autoiogous nerve group (P < 0.05); The degradation and absorption of polylactic acid tube were obvious in the tissue-engineered nerve group and autologous nerve group. CONCLUSION: Human bone marrow stromal stem cells can be induced to differentiate into Schwann cells in vitro, and tissue-engineered nerve constructed with Schwann cells, extracellular matrix and degradable polylactic acid tube can repair peripheral neurologic defect.

[Objective]To study the possibility of differentiation of rabbit marrow mesenchymal stem cells(MSCs)into endothelial cells in vitro.[Method]BMSCs of rabbits were obtained by using gradient centrifuge method.The adhesive cells were preserved to passage culture to get pure MSCs.MSCs in the second generation were used.After induction with vascular endothelial growth factor(VEGF),microscopic exarm,cytoimmunofluorescent staining confirmd the trial group cells becomes to endothelial cells.W-P corpuscles which was the symbol of endothelial cells were observed by transmission electron microscope.[Result]The differentiated cells demonstrated the characters of endothelial cells under phase contrast microscopy.The cytoimmunofluore-scent staining showed that the trial group cells were induced to endothelial cells.W-P corpuscles could be seen under transmission electron microscope.[Conclusion]The adult rabbit BMSCs can present features of endothelial cells in certain induction medium,they are ideal donor cells of tissue engineering vascularization.

Tissue factor (TF), a transmembrane glycoprotein with a molecular mass of 47000, plays an important role of coagulation within vessel wall. Recently, people also present that TF have identifying and regulating function in cells signaling. And it contributes in the pathogenesis of atherosclerosis, angiogenesis and restenosis. This review presents the development of TF in above mentioned .

A simple, rapid and accurate method is described for the determination of icariin in Fuchun Tablets by reversed-phase high-efficiency liquid chromatography. The samples were first extracted with 70% alcohol for 50 minutes The resulting solutions were chromatographed on aYWG-C18 column.By using a mobile phase of methanoltetrahydrofuran-water (26.5:15.9:56.7) and a detection wavelength at 274 nm, the recovery for 101.02%, CV=2.4%,are obtained.The method can be employed for the quality control of Fuchun Tablets.

Medical quality control is at the core of the various managerial tasks of the hospital and the managerial ideas involved determine the quality of the control. The authors analyze in depth the structural features of fundamental, link and terminal medical quality, and in light of their experience in hospital management, put forward a principle of and a framework of ideas for medical quality control. The principle is as follows: focusing on the patients, putting quality at the core, laying equal stress on fundamental, link and terminal quality, and promoting simultaneously self-control and supervision in an all-round way. The framework of ideas is as follows: focusing on the patients should be based on putting quality at the core; fundamental medical quality should be based on basic rules and regulations; link medical quality should be based on the "three basics and three aspects of strictness" ; and terminal medical quality should be based on the education and involvement of the entire staff.

Objective To describe the preoperative factors of prolonged intensive care unit length of stay after coronary artery bypass grafting. Methods From 1997 to 2009, 1318 patients underwent isolated CABG in our hospital. Retrospective analysis was performed on these cases. Univariate and multivariate analyses for preoperative risk factors were performed. Prolonged length of ICU stay was defined as initial admission to ICU exceeding 72 h. Results The mean age of patients ( 322women and 996 men) was (67.4±9.4) years. Of 1318 patients undergoing isolated CABG from 1997 to 2009, 205 experienced prolonged length of ICU stay. The length of ICU stay was (40.1 ± 22.5 ) hours and ( 122.6 ± 48.7 ) hours separately.Overall in-hospital mortality was higher among these 205 patients ( 13.7% vs. 1.2%, P ＜0.05 ). The overall mortality was 3.1%. In univariate analyses, there were statistically significant differences with respect to the percentage of CPB, total bypass time, cross-clamp time, number of distal anastomoses, use of pressor agent, use of intro-aortic balloon pump,time of ventilation and hospital mortality. The significant risk factors were age, NYHA class Ⅲ/Ⅳ, left ventricular ejection fraction(LVEF) ＜0.40, renal failure, cerebrovascular and/or peripheral vascular disease, chronic obstructive pulmonary disease, recent acute myocardial infarction, prior percutaneous coronary intervention, left main stenosi, three-vessels disease. The variables entered into the multivariate logistic regression were age, NYHA class Ⅲ/Ⅳ, LVEF ＜0.40, renal failure, chronic obstructive pulmonary disease, recent acute myocardial infarction, prior percutaneous coronary intervention, three-vessels disease. According to the outcome of multivariate logistic regression, we can conclude the model of probability forecast and create a new variable named Pre. The area under ROC curve of the new variable Pre was larger than other variables. Conclusion The main risk factors of prolonged ICU length of stay were LVEF ＜ 0.40, recent acute myocardial infarction, renal failure and chronic obstructive pulmorary disease. The AUC of variable Pre was higher than other' s , which indicated that new variable Pre combining each variable was more valuable than single variable with respect to prediction. A predicted probability of 0. 754 was used as cut-off point for the prognostic test.

Applying H-index combined with other evaluation index of qualitative and quantitative evaluation for seientifie research ability, levels of researchers as well as academie journals, is becoming inereasingly concerned and will gradually be applied. The paper discusses the connotation, extension, feasibility, limitations on H-index and further analyzes the applicability of using H-index to evaluate the quality of academic journals.