Child ; Early Diagnosis ; Hand, Foot and Mouth Disease ; diagnosis ; Humans

OBJECTIVE:To provide reference for the rational drug use and glycemic control for patients with type 2 diabetes. METHODS:160 patients with type 2 diabetes in 3 communities of Tianjin were divided into 2 groups based on the understanding of the diabetic knowledge,group A(86 cases)had understanding of diabetic knowledge and group B(74 cases)had no. They were carried on the questionnaire survey about the general information,medication and glycemic control. RESULTS:A total of 160 ques-tionnaires were conducted,and 160 were effective with the effective rate of 100%. The proportion of patients with highly educated (college or above)in group A was significantly higher than group B,low education(secondary or below)was significantly lower than group B(P<0.05). The proportion of patients with medicine background in group A was significantly higher than group B(P<0.05). There were no significant differences in the use ratio of different types of drugs for diabetes between group A and group B (P>0.05),however,the use ratio of self-purchase functional food in group A was 0,and group B(60.8%)was significantly high-er than group A(P<0.05). The recent self-test average blood glucose levels,the average blood glucose levels in the investigation day,the 2 h postprandial blood glucose and glycosylated hemoglobin levels in group A were significantly lower than group B(P<0.05). CONCLUSIONS:The medication and glycemic control of patients with type 2 diabetes is closely related to the understand-ing of glycemic knowledge. Therefore,propaganda and education of medication and related functional food for patients need to be strengthened to promote the rational medication.

Objective To identify the chemical components of traditional Chinese medicine by liquid chromatography-mass spectrometry.Methods Chemical components of 86 traditional Chinese medicines were identified by two methods,observation group with LC-MS method and control group with traditional LC methods.The identification efficacy,accuracy,and identification time between two methods were compared. Results The excellent rate in observation group was 76.74% (66/86),the excellent and good rate was 90.70%(78/86),which were significantly higher than those in control group (P<0.05 ).83 kinds of traditional Chinese medicine were successfully identified in observation group,the success rate was 96.5 1%,significantly higher than control group(P<0.05).The identification tine,retention time after correction of errors in observation group were significantly less than control group(P<0.05 ).Conclusion LC-MS has high accuracy,short identification time and wide adaptation range in identification of chemical components of traditional Chinese medicine.

Animals ; Birds ; Influenza A Virus, H5N1 Subtype ; Influenza in Birds ; virology

Objective To explore the recurrence-prevention effect of oral contraceptive and levonorgestrel-releasing intrauterine system (Mirena) after hysteroscopic endometrial polypectomy.Methods One hundred and seventy-four patients who received hysteroscopic endometrial polypectomy were enrolled in this research.The patients were informed and divided into three groups according to their selection:51 cases were given oral contraceptive since one month until 12 months after the surgery (oral contraceptive group); 60 cases were received Mirena since one month after the surgery (Mirena group) ; and 64 cases were received no treatment after the surgery (control group).The groups were followed up at 3,6,12 months after the surgery and compared the recurrence rate,menstruation,level of hemoglobin and complication rate.Results The recurrence rate in oral contraceptive group,Mirena group and control group was 3.9％(2/51),3.3％ (2/60) and 19.0％ (12/63),respectively.The recurrence rate in control group was higher than that in oral contraceptive group and Mirena group,and there was significant difference (P ＜ 0.05).The proportion of low menstruation volume in control group was lower than that in oral contraceptive group and Mirena group,and there was significant difference (P ＜ 0.05).The level of hemoglobin in control group was lower than that in oral contraceptive group and Mirena group [(124.55 ±9.33) g/L vs.(133.71 ± 11.03),(135.89 ±6.88) g/L],and there was significant difference (P ＜ 0.05).The incidence of complication in Mirena group [18.3％ (11/60)] was less than that in oral contraceptive group[35.3％(18/51)],and there was significant difference (P ＜ 0.05).Conclusions Oral contraceptive and Mirena after hysteroscopy for endometrial polys significantly decrease the recurrence rate.The complication rate of Mirena is lower and it is a safe and effective way to treat and prevent the endometrial polyp.

Neonatal intrahepatic cholestasis caused by Citrin deficiency(NICCD) is one of phenotypes of Citrin deficiency.It's an autosomal recessive disorder which was mainly seen in East Asia,including China.Case of NICCD was reported firstly by Japanese in 2001.In south area of China,the morbidity of NICCD is higher than that in north area of China.Most of the patients with NICCD has benign prognosis.Symptoms resolve within the first year of life,thus making a diagnosis difficult after this time.But few of patients will develop liver failure,even be fatal to life.Early diagnosis,regular follow-up and proper management may improve the prognosis.

Combined small cell lung cancer (C-SCLC) is a special subtype of small cell lung cancer (SCLC),which has a low incidence and diagnostic rate.However,the incidence and diagnostic rate appear an increasing tendency recently.The clinical features of C-SCLC are similar to the pure SCLC,while it has a relatively limited stage.The main treatment pattern of C-SCLC is multimodality therapy,though the response to chemotherapy in C-SCLC is relatively poor.Survival between patients with C-SCLC versus SCLC is similar.KPS,stage,composite components,tumor location and diameter,surgery margin are prognostic factors.Radiotherapy can benefit for the patients with ⅢA/ⅢB disease,positive lymph nodes,or with more metastatic lymph nodes after surgery.

Objective:To investigate the protein expression levels of breast cancer metastasis suppressor 1 (BRMS1) and Con-nexin 43 (Cx43) in thyroid cancer and their correlation with clinicopathologic parameters. Methods:Immunohistochemistry Streptavi-din-Peroxidase method was used to detect the BRMS1 and Cx43 protein expression in 195 tissue samples, including 90 cases with thy-roid carcinoma, 45 cases with thyroid adenoma, 30 cases with nodular goiter, and 30 cases with normal thyroid glands. Results:The positive rates of BRMS1 and Cx43 expression was 56.7%(51/90) and 41.1%(37/90) in thyroid carcinoma, respectively, which are sig-nificantly lower than the rates in thyroid adenoma, nodular goiter, and normal thyroid gland tissues (P<0.001). Of the three pathological types of thyroid cancer, the positive expression rate of Cx43 was 61.9%in papillary carcinoma, 27.8%in medullary carcinoma, 27.3%in follicular carcinoma, and 12.5%in undifferentiated carcinoma. Statistical differences in the BRMS1 expression among papillary car-cinoma and the other pathological types were also noted. Unlike the patients without lymph node metastasis, the positive expression of BRMS1 and Cx43 proteins were both significantly low among patients suffering from nodal metastasis. Subgroup analysis shows that the positive expression of BRMS1 and Cx43 protein gradually decreased with TNM staging. In addition, a positive correlation was ob-served between the BRMS1 and Cx43 protein expression (r=0.494, P=0.032). Conclusion:The decreased expression of BRMS1 and Cx43 proteins is significantly correlated with the metastasis of thyroid cancer and malignant grade. The combined detection of the two proteins can be ideal biomarkers for judging the prognosis of thyroid carcinoma.

Objective: To analyze the regulation of hospital accounting procedure under the new hospital accounting system. Methods: Summarize the achievement in accounting and find the existing problems by field investigation. Results: Because the content of accounting system reform is big and the requirement is high, the accounting is not in coincident. Conclusion: Since there is imperfection in accounting and unrelated accounting procedure, it is needed to repeat, clarify and unify the management, so as to standardize the hospital financial behavior and reflect the accounting information accurately.

Objective To explore the value of MRI sequence and MRA for diagnosis of moyamoya disease(MMD).Methods Retrospective analysed of 1 8 cases of moyamoya disease clinical datas,1 8 cases were used routine head MRI scan,including T1 WI, T2WI,DWI,transverse and sagittal T2WI sequence FLAIR;MRA three dimensional time of flight(3D-TOF).Results 18 cases of patients with MRA showed bilateral internal carotid artery,anterior cerebral artery distal and proximal middle cerebral artery steno-sis or occlusion of signs.Among them,1 1 cases were found with secondary cerebral infarction,3 cases of cerebral hemorrhage,7 ca-ses of centrum semiovale,corona radiata and periventricular cerebral ischemia,4 cases of cerebral atrophy,8 cases of cerebral soften-ing and gliosis.Conclusion MRI and MRA examination have important value in the diagnosis of moyamoya disease,treatment.