In the paper,we will deeply research sorts of ethical problems in medical genetics and their origins through a view of the human dual evolutions,and bring forward the viewpoint that any ethical problem can be originated from the conflict between human biological evolution and cultural evolution.Based on fully reasoning the relation between ethical problems in medical genetics and human evolution,the authors put forward a series of corresponding strategies to solve the ethical problems in medical genetics.

Cross-lingual strategy is a teaching methodology in which the mother tongue is employed as a reference or comparison.Based on the English teaching practices in China,this article explores the importance and significance of cross-lingual strategy in English classroom teaching from the perspectives of second language acquisition theory,contrastive linguistics and psychological linguistics.

For medical interpretation,medical students enjoy the advantages of professional knowledge.Based on the case of the Second Military Medical University,this paper elaborates on the necessity and reasonableness of opening the optional course of medical interpretation for medical students,and makes further exploration on the methods and strategies of cultivating medical interpreters in higher medical education from the perspectives of trainee selection,knowledge structure and course designing.

Objective To explore the effect of aconitine on serum zinc finger protein 41 and secreted protein acidic and rich in cysteine in ventricular septal defect model rats.Methods 80 ventricular septal defect model rats were randomly divided into two groups, experimental group ( n=40) were treated with 0.05 mg/kg aconitine via tail vein injection for 7 consecutive days;control group (n=40) were treated with normal saline via tail vein injection for 7 consecutive days.Then, the abdominal aorta blood of each rat was collected, and the contents of zinc finger protein 41 and SPARC in two groups were detected by Western blot and ELISA method,seperately.Results Western blot results showed that the expression of zinc finger protein 41 and SPARC in serum samples of experimental group were significantly lower than that of control group ( P<0.05 ) .ELISA results showed that the contents of zinc finger protein 41 and SPARC of experimental group was significantly lower than that of control group ( P<0.05 ), respectively.Conclusion Aconitine can decrease the expression of serum zinc finger protein 41 and SPARC in ventricular septal defect model rat.

Urinary tract infections(UTIs) are prevalent disorders of the urinary system, primarily caused by pathogens such as uropathogenic Escherichia coli(UPEC). These infections significantly impair patients' quality of life and increase the risk of urosepsis. Although antibiotic therapy can alleviate symptoms, prolonged use often leads to drug resistance and recurrence, underscoring the necessity for developing novel prevention and treatment strategies for UTIs. In recent years, UTI vaccines, as a specific preventive approach, have shown promising progress, which are broadly categorized into three types:whole-cell/lysate vaccines, live attenuated vaccines, and subunit vaccines. Whole-cell/lysate vaccines, such as Uromune,Strovac, and OM-89/UroVaxom, have already been commercialized. In contrast, live attenuated vaccines and subunit vaccines, including ExPEC4V and ExPEC10V, remain in the preclinical research stage. In this paper, the mechanism underlying UTIs and the recent advancements in UTI vaccine development are reviewed, aiming to provide a reference for the research and development of UTI vaccines in China.

Axilla ; Breast Neoplasms ; pathology ; surgery ; Female ; Humans ; Lymph Node Excision ; Lymph Nodes ; pathology ; surgery

Humans ; Myocardial Infarction ; diagnosis ; Takotsubo Cardiomyopathy ; diagnosis

Aging ; Animals ; Male ; Nitric Oxide ; metabolism ; Rats ; Rats, Sprague-Dawley ; Superoxide Dismutase ; metabolism ; Testis ; metabolism

Animals ; Biocompatible Materials ; therapeutic use ; Bone Regeneration ; Bone Substitutes ; therapeutic use ; Bone Transplantation ; Collagen ; therapeutic use ; Guided Tissue Regeneration, Periodontal ; methods ; Humans ; Membranes, Artificial ; Periodontal Diseases ; surgery ; Polytetrafluoroethylene ; therapeutic use

MircoRNAs (miRNAs) are widely existing inorganisms, non-coding small RNA. MircoR-NAs play important role in cell proliferation, apoptosis, stress resistance and fat metabolism. In vitro studies indicate that miRNAs are important factors in platinum resistance of ovarian cancer cell lines. However, the pathway of platinum resistance of ovarian cancers is complex. Studies find miRNA expression play important roles in the sensitivity of platinum resistance of ovarian cancer cell lines , and can be used as an early alert for platinum resistance. Changing the expression of miRNA even can reverse the platinum resistance . But the regular role of miRNAs in target genes network is still unconfirmed. Thus, more studies about miRNA in vivo and animal tumor models are needed to identify the function of miRNAs in platinum resistance of ovarian cancer.