Nishihira and Araki grasped the living body as sensory-motor system, and thought negative potential appearing 25 msec after stimulus of S. S. C. P. as potential arriving at the first sensory area and speculated potential appearing 50-56 msec in advance of muscle discharges as being integrated of motor cortex neurones in the present experiment.
Therefore, the purpose of the present experiment is to investigate the hypothesis that delay and quickness of reaction movement execution depends on delay and quickness of transaction process between sensory and motor area and, also, to identify the distribution over the scalp of motor potential.
The present experiment gave the following results.
1. As for the distribution over the scalp of motor potential, the amplitude of motor potential at Cz showed maximum in case of the left hand reaction movement to right median nerve stimulus. however, comparing the amplitude of motor potenital at C4 with at C3, the amplitude of motor potential at C4 was higher than at C3.
Comparing the amplitude of motor potential at C3 with at C4 except for at Cz, the amplitude of motor potential at C3 was higher than at C4 in case of the right hand reaction movement to right median nerve stimulus.
2. Investigating correlation between reaction time and sensory-motor integration time at C3, C2, C4, there was a higher correlation.
3. Correlation between reaction time and the amplitude of CNV at C2 showed inverse proportion. In addition to, correlation between reaction time and appearance latency of CNV was obscure.

The view which movement-associated cerebral potentials preceding voluntarily, self-paced movement are recorded through the human scalp is well known at present. Then, it is the focus of the present study that what functional significance of each component is. However, the present study reports of N 1 potential constituting movement-associated cerebral potentials were almost based on data of right handedness. Therefore, the authors thought that only data obtained from right-handedness are inadequate because of elucidating in more detail functional significance.
The purpose of present study was intended to investigate functional significance of N 1 potential through the comparison between the distribution over the scalp of N 1 potential of right-handedness and left-handedness.
The following results were obtained;
1) The amplitude of N 1 potential preceding voluntary right hand movement in case of right-handedness showed predominantly high tendency at Cz, C3 and also, showed high tendency at Cz, C3 in case of left-handedness. But, N1 potential of left-handedness did not show more significant tendency at Cz, C3 than right-handedness in voluntary right movement.
2) The amplitude of N1 potential preceding voluntary left hand movement showed high tendency at Cz, C4 in case of right-handedness. But, in case of left-handedness, there were the cases that the amplitude of N1 potential showed high tendency at Cz, C4 and did not show.
3) The amplitude of N1 potential preceding voluntary bilateral simultaneous movement showed high tendency at Cz, C3 in case of righ-handedness and showed clear asymmetry. In case of left-handedness, there were two types of subjects who showed asymmetry and not.
From the results described above, the authors may conclude that the findings which N1 potential shows preponderance over the hemisphere contralateral to the moving limb are based persistently on data of right-handedness and would not be able to apply to data of left-handedness. However, the results of the present experiment were applied to subjects assessed by assesment criterion of dominant and none-dominant hand described in“EXPERIMENT METHOD”and there was the limit of the present experiment in the assessment method of dominant and none-dominant hand.

In order to investigate the association of alpha-blocking with motor set under the condition of simple reaction movement, the scalp distribution of alpha wave envelope recorded by averaging method was compared with that of slow potential changes. The results were as follows.
1) The slow potential changes (readiness potential, early and late component of CNV) were large over the central and frontal area. The readiness potential was larger over the contralateral than the ipsilateral central motor area, while the early component of CNV showed bilateral spread. The late component of CNV showed the similar scalp distribution to that of readiness potential, but the latter was much more lateralized.
2) The alpha-blocking was bilaterally symmetrical over the central and occipital area under the condition of photic stimulus without movement. But the alpha-blocking accompanying preparatory signal increased over the frontal and central area compared with control alpha-blocking, and was larger over the contralateral than ipsilateral central motor area.
3) The maximal alpha-blocking rate showed to correlate negatively with its latency under each condition. The difference in alpha-blocking rate at the onset of the imperative stimulus between reaction movement and control showed to correlate negatively with reaction time.
From these findings, it seems that alpha-blocking accompanying preparatory signal reflects not only input system but also readiness potential component, and that in temporal respect alpha-blocking increases at the onset of movement.

The interactive effects of exercise intensity and physical activity level on the brain and cognition of young adults were investigated using the electromyographic reaction time (EMG-RT), the P3, and the NoGo P3, as well as the contingent negative variation (CNV) of event-related brain potentials. Participants (n＝26 : 24.0 ± 0.7 years) were divided on the basis of their regular physical activity level into active and inactive groups. Then, they performed a Go/NoGo reaction time task in the no exercise, control condition ; as well as after light, moderate, and hard cycling exercises. Results indicated that increases in P3 and NoGo P3 amplitude following moderate exercise were larger in the inactive group, suggesting that inactive individuals were more sensitive to exercise intensity than active individuals. Active individuals might be better able to sustain their attention during the Go/NoGo reaction time task, despite the exercise intensity. These findings are suggestive of a differential effect of exercise intensity on cognitive function that might be dependent on the level of regular physical activity. The effects of exercise intensity on EMG-RTs were observed across groups. However, the P3 latency was not affected by exercise intensity. These contradictory results are possible related to the nature of the cognitive task, such as its difficulty. Moreover, increases in CNV amplitudes following moderate exercise were larger than in other exercise conditions across groups, suggesting that motor preparation process is also facilitated by moderate, acute exercise. These findings provide additional evidence for the beneficial effects of acute aerobic exercise on the brain and cognition of young adults.

The purpose of the present experiment is to identify, in detail, results of the preceding experiment of authors that the amplitude of N₁ potential was dominant over motor cortex area contralateral to moving limb, with bipolar lead and is to investigate negative potential appearing the scalp preceding voluntary movement depends on a precaution stimulus or on readiness of movement execution only.
In addition to, discussing' the difference of CNV (Contingent Negative Variation) and N₁ potential is, also, the purpose of the present experiment.
The present experiment gave the following results.
1. The results obtained with monopolar lead were that the amplitude of N₁ potential was maximal at lead placement Cz in all movement.
2. The results obtained with bipolar lead were that the amplitude of N₁ potential showed, relatively, lower tendency in the combination within central area and showed, relatively, higher tendency in the combination of other lead placement to central area.
3. Judging from all the scalp, the amplitude of N₁ potential showed high tendency at central area.
4. In particular, clear difference was identified between the latency of CNV and that of N₁ potential.
5. As showing much the same amplitude except for lead placement Cz, CNV extended from central area over the scalp.

The somatosensory evoked potential (SEP) is attenuated (gating) and the spinal motoneuron pool is facilitated before and during movement. However, the relationship between these changes has not been elucidated. In the present study, the SEP and the evoked electromyogram were simultaneously recorded during a discriminative reaction task in seven healthy subjects. Electrical stimulation applied to the posterior tibial nerve in the popliteal fossa was used as a response signal. The experimental condition were: 1) full relaxation and no response to either right or left stimulation (Control) ; 2) no response to right stimulation and quick contraction of right ankle with left stimulation (L-R) ; 3) no response to left stimulation and quick contraction of right ankle with right stimulation (R-R) . Right and left legs were randomly stimulated under each condition. The H-response gains of the right leg with movement were significantly facilitated compared to the left leg without movement in L-R and R-R conditions. The results indicated that movement enhanced the motoneuron excitability regardless of sensory concentration. In the L-R condition, N 40 at Cz evoked by left operative stimulation that produced right leg movement was significantly increased. However, in the R-R condition, it was significantly attenuated when it was recorded by right operative stimulation that produced right leg movement. These results indicated that concentration on the operative stimulation enhanced the N 40 gain and it reflected the concentration on sensory information, but simultaneously induced the movement, and its gain was strongly controlled by the motor system.

This study was carried out to investigate the influence of pre-movement tonic contraction on the Contingent Negative Variation (CNV) and Flexor Carpi Radialis (FCR) H reflex between the warning (WS) and response signal (RS) (foreperiod : FP) . Two levels of contraction were designed and the accompanying FCR Electromyography (EMG) was directly returned to the subject to sustain constant contraction. The subjects were 10 normal volunteers. Either small or middle (7.9±5.6% or 16.0±6.3% of the standard FCR EMG) contraction was sustained and the isometric wrist flexion movement was performed as quickly as possible following the RS.
EMG Reaction time (RT) in the small contracting condition was shorter than that in the resting condition (nothing performed during the foreperiod) in almost all subjects, but in the middle contracting condition EMG RT was not similar. The CNV amplitude for the late period of the FP, which was considered to be related to the motor preparation, was larger in the middle contracting condition than in the resting condition, although the small contracting condition was similar to the resting condition. The H reflex amplitude for the late period of the FP tended to be smaller than the control level in the small and middle contracting conditions, but it was not significant. However, in over half of the subjects, whose CNV amplitude for the late period of the FP increased linearly depending on the conditions, the H reflex amplitude was smaller than the control level in both contracting conditions, but it was not linear. These results indicate that the modulation of the EMG RT was not directly associated with the CNV or H reflex amplitudes for the late period of the FP, and a functional difference in the set for the RS between the spinal and the upper level of the central nervous system was present.

The purpose of this study was to examine how S-R compatibility affected P 300, the stimulusevaluation process and response process. The P 300 component is thought to reflect information processing of stimuli. Previous studies used visual stimuli. In this study, we measured S-R compatibility effects on EMG-RT and P 300 using electrical somatosensory stimuli. Subjects performed the oddball task (Task 1) and the four-choice stimuli response task (Task 2) . They were presented electrical stimuli through ring electrodes on the index and little fingers of both hands and instructed to respond quickly to stimuli. S-R compatibility was decided by position of the stimuli. EMG-RT and P 300 latency for compatible and incompatible conditions were analyzed.
For ERP analysis, data of subjects who reacted faster to compatibility ware used. Neither P 300 latency nor amplitude differed significantly between compatibility and incompatibility in Tasks 1 and 2, but for Task 2, latency tended to be prolonged by incompatibility. Therefore, it is thought that S-R compatibility mainly has an effect on response processing. However, judging from the tendency of P 300 latency to be prolonged by incompatibility for Task 2, it was considered that there is the possibility that S-R compatibility influenced P 300 latency, even if using a somatosensory stimulus.

We evaluated motor unit (MU) fatigue in the first dorsal interosseous muscle (FDI) using the collision principle. Eight healthy men exerted 70% (short-duration fatigue task: SDF task) and 30% (long-duration fatigue task: LDF task) maximum voluntary contraction of isometric abductions in the left FDI until exhausted. Before and after voluntary contractions, the ulnar nerve was stimulated at the wrist and elbow with supramaximal intensity, and a pair of M-waves was obtained. Fatiguerelated changes were studied in mean power frequency (MPF), averaged rectified value (ARV) calculated from surface EMG, and motor nerve conduction velocity (MCV) and distribution of motor nerve conduction velocity (DMCV) calculated from M-waves. The MPF of voluntary EMG decreased, whereas ARV increased significantly during SDF and LDF tasks, indicating fatigue had developed in the FDI. Endurance was significantly shorter in the SDF task than in the LDF task (p<0.01), whereas differences between tasks were not seen in MPF and ARV changes. Tasks did not affect MCV, but lower components in DMCV increased for both tasks. Increased lower components were larger in the LDF task than in the SDF task. The shift in DMCV indicated that fatigued MUs stopped activity and enduring MUs, which had lower axon conduction velocity, were activated selectively. These results suggest that the collision principle is applicable in evaluating motor unit fatigability.

In this study, we examined changes in the amplitude of differential digital photoplethysmogram (ΔDPG) and the power spectral changes of EEG at rest during cold water immersion of the contralateral fingers (2°C), and after alcohol intake (0.3 g/kg) in 8 male subjects. This experiment showed that the ΔDPG amplitude decreased at rest and finger blood pressure was increased during the cold water stimulation, but there was no signifincant change in heart rate and EEG power spectrum. On chronological measurements for 30 minutes after alcohol intake, ΔDPG amplitude decreased slightly and finger blood pressure increased. Heart rate also tended to increase, and the alpha 1 power (8.0-9.8 Hz) on EEG gradually increased. The ODPG and finger blood pressure responses to cold water stimulation every 10 minutes was decreased after alcohol intake, whereas heart rate was not affected. However, a decrease in the alphal power after stimulation was revealed. From these results, it may be concluded that during 5-10 s of cold water stimulation, increased skin sympathetic nerve activity was one of the factors that raises blood pressure.