Abstract: Objective To study the effect and mechanism of Huaxian Sanjie compound granule on silicosis fibrosis in rats. Methods The specific pathogen free male SD rats were randomly divided into control group, silicosis model group and - interventiongroup,withsixratsineachgroup.Disposableventilatorcombinedwithnon exposedintratrachealdripwasused,the ratsinthesilicosismodelgroupandinterventiongroupweretreatedwith 1.0mLsilica suspensionwithamassconcentrationof 50.0 g/L to establish silicon dust rat model, while the rats in the control group were treated with equal volume of 0.9% sodium chloride solution. After 24 hours of dust exposure, the rats in the intervention group were given 10 mL/kg body weight of Huaxian Sanjie compound granule suspension with a mass concentration of 212.5 g/L by gavage, while the rats in the control group and silicosis model group were given the same amount of 0.9% sodium chloride solution, once a day. Three rats in each groupweresacrificedonthe14thand28thday,respectively,andtheirlungtissueswereseparatedforpathologicalexamination.----Thelevelsofinterleukin6(IL6)andtransforminggrowthfactorβ