1.To study and structure a preliminary indicators system for evaluating the projects of Hospital in finished phase
Yuanyuan WANG ; Ruihua SUN ; Fan FAN ; Libo YAO ; Wenjie LI
Chinese Journal of Medical Science Research Management 2013;26(5):303-308
Objective To structure a preliminary indicators system for evaluating the projects of Hospital in finished phase.Methods With Delphi method,collect the experts' opinion of the importance of every item.With AHP (Analytic hierarchy process) method,calculate the weight coefficient of every item.Results The positivity of the experts was fine; The authority coefficient of two rounds were 0.859 and 0.833,the consultation results are reliable; The coordination coefficient of two rounds were 0.254 and 0.553,according to the significance test,p values were less than 0.05,indicating that the results were desirable.According to the score of every item,we got the weight index of every items based on the AHP method.Finally we structure the indicators system including 3 primary indicators and 10 secondary indicators.Conclusion The preliminary results of this study provide a reference for the performance evaluation of projects in finished phase of China-Japan Friendship Hospital.
4.Review of effect of Chaihu Shugan Powder on post-stroke depression
Weihong FAN ; Qing YANG ; Jianping YAO
International Journal of Traditional Chinese Medicine 2010;32(2):176-177
The rate of stroke has been rising year by year and become the world's major cause of mortality and disability. The high rate of disability did not only bring economical burden to society and family, but also induce psychological damage to patients. Post-stroke depression (PSD) is a most common mental complications of stroke. In recent years, More and more attentions have been paid to PSD. This article reviewed the cause and mechanism of PSD and the treatment with Chaihu Shugan Powder on it.
5.Effect of single and low dose propofol intravenously on cardiovascular and adverse response during extubation in patients undergoing ovarian cancer operation
Fan YANG ; Yao GUO ; Lingxin MENG
Chinese Journal of Postgraduates of Medicine 2010;33(3):21-23
Objective To observe the effect of single and low dose propofol administered near the end of surgery on the cardiovascular and adverse response during extnhation in patients undergoing ovarian cancer operation. Methods Fifty ASA Ⅰ - Ⅱ patients undergoing selective ovarian cancer operation were randomly allocated into group S and group P,with 25 patients in each group. In group S, inhalation of sevoflurane was discontinued at about 2 minutes before the end of operation. In group P, inhalation of sevoflurane was discontinued at about 5 minutes before the end of operation,and at the same time,0.5 mg/kg of propofol was administered intravenously. The systolic blood pressure (SBP),diastolic blood pressure (DBP),heart rate (HR) and recovery time of consciousness were recorded at 5 min before extubation (t_1),during extubation (t_2), 1 min after extubation (t_3), and 5 rain after extubation (t_4). The incidence of agitatian,bucking,nausea and vomiting were recorded by an observer who was blind to this study. Results There were statistical differences in HR,SBP,DBP at t_2-t_4 between two groups. The recovery time was (10.39 ± 1.26) min in group P,and(9.57 ± 1.25) min in group S,there was significant difference between group P (2 cases) and group S (9 cases)(P< 0.05). There was significant difference in the incidence of agitation between two groups (P< 0.05). Conclusion Low dose propofol before extubation can inhibit stress and cardiovascular response and decrease the incidence of agitation, bucking, nausea and vomiting.
6.Effect of double-layer human amnion on wound healing in deep second-degree burns of animals
Xuanhe SONG ; Changdong FAN ; Yao LI
Chinese Journal of Tissue Engineering Research 2008;12(27):5389-5392
BACKGROUND: Previous research reveals that, single-layer human amnion is effective to cure superficial bums, but it is still unsatisfactory.OBJECTIVE: To observe the effects of double-layer radiation-treated human amnion on the healing of deep second-degree burn wound.DESIGN, TIME AND SETTING: Randomized control study was performed at the Animal Experimental Center in the First Affiliated Hospital of Harbin Medical University (Harbin, Heilongjiang, China) from December 2006 to May 2007.MATERIALS: Fifty adult Wistar rats of clean grade were burned and then assigned into five groups at post-injury 4, 6, 8,10 and 12 days, with ten rats in each group. Subsequent to the chorion removal, the fresh human amniotic membrane was dried and prepared into double-layer films, which were aporate or porous. Human amnion was then radiated using γ-ray for further use.METHODS: Following dorsal skin epilatiou and the anesthesia, all the rats were immersed for 8 seconds in boiling water to induce rat models of deep second-degree burns. One side of the burn wound was applied human amnion, while the other side was applied oil gauze.MAIN OUTCOME MEASURES: Gross observation of the bum wound was carried out at post-injury 4, 6, 8, 10 and 12 days. Meanwhile, light microscope, scanning electron microscope and transmission electron microscope were employed to detect the histological changes of the burn wound, as well as bacteriological examination.RESULTS: Fifty rats were all involved in the result analysis. Sphacelism and crust were found in the burn wound treated with oil gauze, with the presence of focal ulcer at post-injury 12 days. Under light microscope, few hairs regenerated in dermis, especially hair follicle and hair root; Scanning electron microscope suggested a large amount of inflammatory exudates and leukocytes; Transmission electron microscope revealed an unclear structure of the cells. Bacteriological examination also indicated that the bacteria aecreted on the surface of burn wound. The treatment of double-layer radiation-treated human amniou healed the burn wound at post-injury 10 and 12 days, and the hairs grew with the same manner as that of normal skin. Epidermis tissues were proved to be normal skin at post-injury 12 days by means of light microscope, scanning electron microscope and transmission electron microscope. Bacteriology was detected to be negative.CONCLUSION: Double-layer radiation-treated human amnion plays a protective role on the burn wound in rats. It may facilitate epithelial growth, avoid wound infection and accelerate the healing of deep second-degree burn.
7.Effect of lappaconitine on perioperative immune function
Fan SU ; Tao WEI ; Shanglong YAO
Chinese Journal of Anesthesiology 2008;28(7):615-618
Objective To investigate the effects of lappaconitine on the perioperative immune function.Methods Twenty-four ASA I or II patients aged 23-64 yr undergoing elective radical mastectomy (8 patients),iaminectomy and vertebral canal decompression (8 patients) or femoral head replacement (8 patients ) were randomly divided into 2 groups (n=12 each): control group (C) and lappaconitine group (L).In group L ondansetron 4 mg was given IV and lappaconitine 8 mg was infused IV over 30 rain before induction of anesthesia.In group C equal volume of normal saline was infused instead of lappaconitine.Anesthesia was induced and maintained with propofol,remifentanil and rocuronium.Lappaconitine 0.28 mg/ml was continuously infused at 2 ml/h after induction of anesthesia in group L.When the patients recovered from anesthesia after operation,PCA with 0.28 mg/ml lappaconitine was started (background infusion 2 ml/h,bolus dose 0.5 ml and lockout interval 15 min).In group C pethidine 50 mg and droperidol 2.5 mg were given IM on demand.Venous blood samples were taken at 30 rain before induction of anesthesia(T1,baseline),immediately (T2) and at 24 h(T3) and 48 h (T4)after operation for determination of TNF-α,IL-2,IFN-γ and sIL-6R concentration by ELISA.CD3,CD4,CD8 and NK cell expression was determined using flow cytometry and the ratio of CD4/CD8 was calculated.The concentrations of IgA,IgM,IgG,CD3 and CD4 were determined by radioimmunoassay.Results Plasma SIL-6R and TNF-α concentrations were significantly lower while IL-2,IgA,IgG,IgM concentrations and CD4/CD8 ratio were significantly higher after operation in group L than in group C.Conclusion Lappaconitine can improve perioperafive humoral immune function thus contributing to its analgesic and anfi-inflammatory effects.
8.Effects of L-carnitine on renal anemia and nutritional status in maintenance hemodialysis patients:a Meta analysis
Bin YAO ; Xiaowei HE ; Xiaoping FAN
Chinese Journal of Primary Medicine and Pharmacy 2014;21(11):1638-1640
Objective The aim of this study was to analyze the influence of combined therapy with L-carnitine and erythropoietin on renal anemia and nutritional status in patients treated with maintenance hemodialysis.Methods The combination of computer and manual searches were used.A Meta analysis was made regarding the effect of combined therapy with L-carnitine and erythropoietin on the improvement of renal anemia and nutritional status in patients treated with maintenance hemodialysis.The quality of the 9 studies was evaluated with the Jadad score.Statistical analysis was carried out by RevMan 5.0.Results A total of 428 patients in 9 reports were analyzed.Metaanalysis showed that there were significant improvement in hemoglobin (Hb) [WMD =9.21,95% CI (7.69 ~10.73)] and hematocrit (Hct) [WMD =2.61,95% CI (2.28 ~ 2.93)],albumin (ALB) [WMD =1.64,95% CI (1.04 ~ 2.24)] and total protein (TP) [WMD =2.72,95 % CI (0.67 ~ 4.77)] in the treatment group compared with the control group.The level of erythropoietin dosage [WMD =-38.24,95% CI (-76.87 ~ 0.39)] was decreased significantly.But there were no significant differences in triglyceride and serum phosphorus.Conclusion Combined therapy with L-carnitine and erythropoietin in patients treated with maintenance hemodialysis leads to significant improvement of renal anemia and nutritional status.
9.Vexation in Middle and High School Students
Hongxia FAN ; Yuqiu LI ; Caiqin YAO
Chinese Mental Health Journal 2002;0(07):-
Objective:To investigate the vexation and relevant attribution in middle and high school students Methods:A total of 539 middle or high school students were sampled from Shanxi Province, they were investigated with a self-made inventory and some of them received interview Result:Most of the students had worries in life, mainly about self-image, control of their parents, pressure of studies, individuality and interpersonal relationships The worst things they worried were relationships between partners,their inefficiency in studies,being quipped by teachers The degree of worrying about appearance and individuality were markedly different between students in middle schools and in high schools Conclusion:It suggests that family, school and society should give enough concern for middle and high school students
10.Effect of single person operating Mammotome system on benign breast tumor and its curative effects
Huitao YAO ; Qinghao FAN ; Han ZHAO
Chinese Journal of Endocrine Surgery 2017;11(2):127-130
Objective To investigate the effect of single operation Mammotome system on breast benign tumor patients.Methods 86 cases of benign breast cancer patients admitted from Jan.2011 to Dec.2015 were divided into the control group (43 cases) and the observation group (43 cases) according to the random number table method.The control group were treated by traditional breast lesion resection and the observation group were treated by single operation of Mammotome system.The mean time of operation,the average blood loss and the size of surgical scar were recorded.The number of patients with deformity of breast and complications was recorded.The satisfaction of the two groups was evaluated by questionnaire.The recurrence rate of the two groups was statistically analyzed.Results The average operation time of the observation group was significantly shorter than that of the control group,and the scar size was significantly smaller than that of the control group (P<0.05).The deformity rate of the observation group was 0%,significantly lower than that of the control group (11.6%).The satisfaction rate was 97.7% in the observation group,significantly higher than that of the control group (83.7%,P<0.05).The postoperative complication rate was 4.7% in the observation group,significantly lower than that of the control group (18.6%,P<0.05).There was no recurrence in the two groups during 6 months of follow-up.Conclusion The application of single breast operation Mammotome treatment for benign breast tumor has the advantages of simple operation,shorter operation time,less intraoperative blood loss and surgical scars.It also can reduce the postoperative complications,keep breast shape,reduce the recurrence rate,so as to improve the patient satisfaction.