Abstract: -
Well characteristic biomarkers are helpful for understanding the disease condition of patients with occupational
pneumoconiosisand predictthediseaseevolution.Currently,related biomarkersarewidelystudied and theyinclude:epithelial
cell injury related biomarkers such as salivary glycochain antigen, Clara cell protein and surfactant protein; inflammatory
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response related biomarkers such as interleukin, tumor necrosis factor α, chemokine, high mobility group protein 1 and
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L selectin; oxidative stress related biomarkers such as superoxide dismutase, glutathione, malondialdehyde, heme oxygenase 1
and lactate dehydrogenase; pulmonary fibrosis related biomarkers such as matrix metalloproteinases and transforming growth
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factor β; non coding RNA such as miR 19a, miR 29 and miR 146a, et al. These biomarkers are helpful to understand the
pathogenesisofoccupationalpneumoconiosisandguidethediagnosis,treatmentandprognosis.However,moreresearchneedsto-bedoneontherepeatabilitytestofbiomarkers,combinedapplicationandtheminingofnoncodingRNAastargetsfordisease
diagnosisandtreatment.