Far beyond simulating manual work with the computer system,hospital informatization entails a combination of information technology with hospital professional work.With a fully understanding of working procedure in hospital,an effective concordance based on informatization requirements is conducted so that the management and the collection of the information can follow the information flow,logistics,capital flow,working flow and organization flow.Management mode and organization framework of the hospital are also adjusted.Thus the hospital operation quality and efficiency are improved,and patients are offered seamless and continuous service,which really reflects the service theory: "Patient First".

Several models about epidermal growth factor receptor tyrosine kinase inhibitors(EGFR-TKI)as first-line treatment in advanced NSCLC show different results.Combination with chemotherapy and EG-FR-TKIs did not indicate survival advantage.However,sequential chemotherapy in EGFR-TKIs and a single agent of EGFR-TKIs as first-line treatment of advanced NSCLC have made tremendous breakthrough,and give a new path in individual treatment of advanced NSCLC.Also EGFR mulatious in targeted therapy of advanced NSCLc has a sood predictive value of the etticacy.

AIM: To develop a method of determining notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 in Naomaitai Capsules(Radix et Rhizoma Ginseng Rubra,Radix et Rhizoma Notoginseng,Radix Angelicae Sinensis,etc.) by HPLC. METHODS: Notoginsenoside R_1,ginsenoside Rg_1 and ginsenoside Rb_1 were determined by HPLC gradient elution method,Inertsil-ODS-3(5 ?m 4.6 mm?250 mm) column with Acetonitrile-water as the mobile phase was used for gradient elution.The flow rate was at 1.0 mL/min and the detective wavelength was at 203 nm.The column temperature was at 35 ℃. RESULTS: There was a good linear relationship at a range of 0.205-1.539 ?g for notoginsenoside R_1(r=0.999 6),the average recovery of 98.07%, and RSD of 0.51%(n=5),0.838-6.285 ?g for ginsenoside Rg_1(r=0.999 4),the average recovery of 97.66%,and RSD of(0.53%)(n=5),0.822-6.165 ?g for ginsenoside Rb_1(r=0.999 6),the average recovery of 98.19%,and RSD of 0.44%(n=5). CONCLUSION: The method is simple,reproducible and accurate with a strong specificify,and can be used for the quality control of Naomaitai Capsules.

Objective To explore the relationship between heart rate variability(HRV)and serum high sensitivity C-reactive protein(hs-CRP)in type 2 diabetic aged patients.Methods Totally 30 aged patients with type 2 DM were enrolled in this study who were selected from the outpatients and inpatients of Department of Gerontology in the Third People's Hospital of Chongqing,and another 30 non-diabetic matched individuals were recruited as control.Their serum hs-CRP and 24 hour-electrocardiography were examined.HRV was assessed by calculating the indices based on statistical operation on RR intervals(time domain analysis)from 24-hour Holter recording,including:standard deviation of normal to normal RR intervals(SDNN),standard deviation of 5-minute mean RR intervals(SDANN)and square root of differences between adjacent NN intervals(rMSSD).Linear correlation analysis was carried out between their serum hs-CRP and HRV.Results HRV parameters of type 2 DM patients were significantly lower than those of non-diabetic patients,but hs-CRP values were significantly higher than those of control.Linear correlation analysis indicated that HRV was in a positive correlation with hs-CRP in type 2 diabetic aged patients.Conclusion Altered autonomic nervous function may be associated with altered serum hs-CRP in aged patients with type 2 diabetes mellitus.

AIM:To establish the quality standards for Qinghuo Tablets(Folium Isatidis,Radix et Rhizoma Rhei,Gypsum Fibrosum,etc.). METHODS:Folium Isatidis,Radix et Rhizoma Rhei,menthol in Qinghuo Tablets were identified by TLC.Indirubin and emodin were determined by HPLC.Agilent-ODS-3(5 ?m,4.6 mm?250 mm) column was used.The column temperature was at 25 ℃.Methanol-0.5% H_3PO_4(75∶25) was used as a mobile phase.The detection wavelength was at 289 nm.The flow rate was 1.0 mL/min. RESULTS:Folium Isatidis,Radix et Rhizoma Rhei,menthol could be detected by TLC.Indirubin showed a good linear relationship at the range of 0.071 4-0.714 ?g,r=0.999 7.The average recovery was 98.95%,and RSD was 0.57%.Emodin showed a good linear relationship at the range of 0.204-2.04 ?g,r=0.999 8.The average recovery was(99.01%),and RSD was 0.79%. CONCLUSION:The established method is rapid,accurate,reproducible with a strong specificify.

A backup data center near the primary data center using Storage Area Network is built with Fiber Channel technology. The specific disaster recovery software used to synchronize the two centers a highly reliable safety and expandable data storage management system with adequate redundancy is developed. Thus disaster recovery service can be provided for the hospital information system when disaster happens. To avoid the system risk and maintain the continuity of the hospital's activities the damaged part of the system will be taken over from.

Adult ; Citric Acid ; adverse effects ; Dust ; Humans ; Male ; Middle Aged ; Occupational Exposure ; adverse effects ; Tooth Erosion ; chemically induced

Objective To investigate the clinical intervention effect of superficial needling at point Fenglong on gastroscopy side reaction.Methods Eighty-two gastroscopy patients were randomly allocated to treatment and control groups, 40 cases each. The treatment group received gastroscopy and superficial needling at point Fenglong, and the control group, gastroscopy and sham acupuncture at point Fenglong. The pain score and the incidence of nausea and vomiting were observed in the two groups during gastroscopy.Results There was a statistically significant difference in the pain score between the two groups (P<0.05). The incidence of nausea and vomiting was 31.7% in the treatment group and 65.9% in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Superficial needling at point Fenglong can effectively reduce the incidence of gastroscopy side reaction.

Neuroanatomy knowledge is the key to improve the teaching quality of neurosurgery and anatomy teachers' participation in neurosurgery teaching can obviously improve teaching effect. Combined with case-based teaching, we enabled medical students to master the system knowledge from the basic to the clinical , cultivating their clinical thinking ability and the ability to solve clinical problems. Cooperation between clinical medicine teachers and basic medicine teachers can promote the update of knowledge, work out teaching plans together, and improve the quality of teaching.

Parkinson's disease (PD) is one of the most frequent neurodegenerative disorders. ?-Synuclein was the first"PD gene"to be discovered. The involvement of ?-synuclein in PD was first suspected after two different ?-synuclein mutations were identified in two kindreds with autosomal-dominant PD. However,the discovery that ?-synuclein is the major component of Lewy bodies-pathological hallmarks of PD, confirmed its role in PD pathogenesis. Pathological aggregation of ?-synuclein might be responsible for neurodegeneration. Multiple factors have been shown to affect ?-synuclein aggregation in vitro or in vivo. In addition, soluble oligomers of ?-synuclein might be even more toxic than the insoluble fibrils found in degenerative diseases. So it is significant to investigate factors affecting ?-synuclein aggregation, especially their accurate effects on the aggregation process.