Objective To explore the application effect of single port laparoscopic techniques in urology grassroots.Methods 60 patients with upper ureteral stones were randomly divided into observation group(using single port laparoscopic technique lithotripsy) and control group (30 cases with open surgery).The surgery time,blood loss,hospital stay,postoperative complications were compared between the two groups and the patients were followed up for three months,the clearance rate of stones and patients' satisfaction were observed.Results The operative time between the two groups had no significant difference(t=1.559,P>0.05).The blood loss of the observation group was significantly less than that of the control group[(128.3±10.32)mL vs.(76.4±9.65)mL],the difference was statistically significant(t=20.003,P<0.01),and the hospitalization time was shorter than that of the control group[(5.86±1.47)d vs.(7.95±1.53)d],the difference was statistically significant(t=5.395,P<0.01).The incidence rate of postoperative complications of the observation group was lower than that of the control group(6.7% vs.30.0%),the difference was statistically significant(x2=5.454,P<0.05).Followed up for 3 months,the ESWL rate(73.3% vs.96.7%) and satisfaction rate (100.0% vs.80.0%) in the observation group and the control group had statistically significant differences (x2=4.705,4.629,all P<0.05).Conclusion The single port laparoscopic technique lithotripsy in the treatment of upper ureteral stones has precise effect,less invasion,high ESWL rate,low complication rate and other advantages,and it is worthy of wide promotion.

Humans ; Maintenance Chemotherapy ; Multiple Myeloma ; therapy

The foot overpronation is termed as pronation persisting more than 25%of stance phase in a walking cycle, which may re-sult from some antenatal or postnatal conditions. Overpronation would lead to abnormal alignment of ankle, knee, pelvis and spine, and re-sult in a set of syndromes of chronic pain. The Navicular Drop Test and the Foot Posture Index are often used as the assessment tools, how-ever, there are several empirical ways for clinic. Foot orthoses, special shoes, taping and training of muscle strength are effective on overpro-nation as well as chronic pain.

BACKGROUND:Overtraining is a series of functional disorder or pathological state induced by continuous fatigue accumulation because exercise load and body function are incommensurate to each other. At present, commonly used methods for establishing rat models of overtraining included treadmil , swimming and climbing rod, but treadmil is comparatively accepted in the world.
OBJECTIVE:To establish the standard of overtraining rat model and to implement objective of model establishment by dynamical y monitoring biochemical indexes and observing behavioral changes.
METHODS:A total of 16 Sprague-Dawley rats were randomly assigned to model and blank control groups. The model group received movement training according to the plan. After adaptable feeding, training was performed, 6 days every week, with a rest of 1 day. Increasing intensity on treadmil was used. From the first week of training, the speed, gradient and running time were gradual y increased. However, the blank control group was conventional y fed, without any training.
RESULTS AND CONCLUSION:Behavior changes of the training rats were arisen after five weeks. Serum creatine kinase levels increased continuously in training process, and higher than basic levels at 5 weeks (P<0.01). Serum urea nitrogen levels persistently increased, and higher than basic levels at 3 weeks (P<0.05). Hemoglobin and serum testosterone levels increased and then decreased, and significantly lower than basic levels at 8 weeks (P<0.05). Behavioral y, overtraining appeared. Simultaneously, hemoglobin and serum testosterone levels were significantly lower than basic levels. Serum creatine kinase and serum urea nitrogen levels were significantly higher than basic levels. These results indicated that the body was in overtraining state. The standard of overtraining rat model was established in this study. The overtraining rat model was established according to the training program when the training was lasted for 8 weeks, the training speed was 30 m/min;every training time was 110 minutes, and the gradient was 15°.

Objective: To evaluate the preventive effect of ephedrine on hypotension under spinal anesthesia in patients with different age. Methods: Sixty patients scheduled for spinal anesthesia were randomly allocated to four groups with 15 each. Group Ⅰ and Ⅱ were adult patients aged from 25 to 55 years old and group Ⅲ and Ⅳ were geratic aged patients of 6575 years old. Every patient received a fluid loading of 7ml/kg before spinal anesthesia. The ephedrine was administrated to group Ⅱ and IV patients in a dose of 10mg i v and 30 mg i m and same amount of normal saline was administrated to group Ⅰ and Ⅲ as soon as spinal anesthesia was performed. Results:Thirty patients in the placebo groups developed a maximal decrease in MAP exceeding 20%. Ten of these (2 in group Ⅰ and 8 in group Ⅲ ) developed a decrease in MAP exceeding 35% and required treatment. In aged groups, all patients in group Ⅲ had a decrease in MAP exceeding 20 %, 53 % of whom, the decrease exceeded 35 %. Conclusion:Prophylactic use of ephedrine is effective in the prevention of hypotension during spinal anesthesia, especially in aged patients.

To assess the effect and the safety of Naoxinqing Tablet in treating cerebral atherosclerosis and angina pectoris of coronary heart disease. Forty-eight patients with cerebral atherosclerosis and 12 patients with angina pectoris of coronary heart disease served as the objects. The effective rates were 83.33% and 75.00% in cerebral atherosclerosis group and angina pectoris of coronary heart disease group respectively, and the total effective rate of Naoxinqing Tablet was 81.67%, the difference being significant as compared with those before treatment (P

The development of the nerves of the small intestine was studied in 26 human fetuses with the gestational age of 11 to 40 weeks.The findings are as follows:(1)The distance between the Auerbach's ganglia and the muscular layer is small in the early fetal period and it increases progressively as the fetus grows.(2)The density of neuropils increases gradually.(3)The number of large gradual vacuoles (LGV) is small in the 3rd month of gestation,and it increases gradually and is quite numerous in the 6th month.(4)The morphology of the synapses is not so typical as that of an adult.(5)The peak values of the stereological morphological parameters of the organelles in the neurons appear between the 4th-6th month and maintain at a relatively high level until the baby is bron.

Objective To explore the effects of recombined human growth hormon-enhanced early enteral nutrition on healing of the patients after operation for sereve abdominal trauma.Methods 60 patients with severe abdominal trauma were randomly divided into PN(n=20),EN(n=20) and EN+ rhGH(n=20) groups.Nutrient status and immune function of 3 groups were detected on the postoperative day 1,7 and 10.Results EN+ rhGH group showed more effective process than EN and PN groups in improving postoperative nutrient status,immune function and nitrogen balance,whose indexs except CD8 changed significantly on the postoperative day 7 and 10 than that in PN group(P

AIM: To investigate the correlation between the left ventricular filling type and geometry modality and functional change of the left ventricle in patients with hypertension. METHODS: Systolic function indexes (FS and EF) and diastolic function indexes (E, A, EAT, EDT, E/A,IVRT) in 120 patients with hypertension were measured by two dimensional ultrasonography (2-DUS) and M-mode and Doppler ultrasound. RESULTS: A rate of 83.5% in patients with hypertension appeared assured plump and configuration changes of left ventricle, and a rate of 84% in patients with hypertension appeared abnormal left ventricular filling function. The morphologic indexes were significantly different clearly in different left ventricular filling types, and the filling indexes were also significantly different in diferent left ventricular shapes. CONCLUSION: IVRT is a more important index than other factors to decide the left ventricular filling function. LVMI plays more important role than other factors in the left ventricular filling function.

Objective To explore the effects of isoalantolactone on the proliferation of human chronic myelogenous leukemia drug-resistant cell line K562/A02. Methods K562/A02 cells were treated with 6.25, 12.5, 25, 50 and 100 μmol/L isoalantolactone for 24 and 48 h, cell viability was analyzed with MMT assay. K562/A02 cells were treated with 10, 15, 20 μmol/L isoalantolactone for 24 h. Flow cytometry was used to examine the effect of isoalantolactone on the cell-cycle and apoptosis of K562/A02 cells. The related proteins were analyzed using Western blot. One-way ANOVA was used for statistical analysis. Results Isoalantolactone effectively inhibited the proliferation of K562/A02 cells in a dose-dependent manner (P<0.05) with IC50 value of (15.00 ±1.03) μmol/L at 24 h, respectively; Flow cytometry displayed that isoalantolactone may induce K562/A02 cells apoptosis in a concentration-dependent manner (P<0.05). The apoptotic rate significantly increased from (2.71 ±0.52) % in the control group to (19.10 ±1.55) %, (27.61 ± 2.32)%and (32.01±3.01)%(F=33.901, P<0.05), respectively, after treatment with 10, 15, and 20 μmol/L of isoalantolactone for 24 h. The percentage of cells in the S phase increased from (57.80±2.11) % to (68.62± 2.89)%, (78.41±3.51)%and (80.61±2.90)%, respectively (F=51.328, P<0.05). Western blot indicated that the expression of bcl-2, p-bcr-abl, p-STAT5, CDK2 and cyclin A significantly decreased (P< 0.05), and that of cytochrome C, Bax, and p21 increased with the increasing of isoalantolactone concentration (P< 0.05). Conclusion Isoalantolactone can significantly inhibit the proliferation of K562/A02 cells through bcr-abl-STAT5 signaling pathway.