The prevalence and adjusted rate of Mental Retardation(M. R.) were 2.70% and 2.68% in the Qin-Ba Mountain Area in South-Shaanxi; 2.78% and 2.80% in childhood respectivety. These rates were all higher than overall rates in Shaanxi and in It is obvious that the prevalence of M. R. could be reduced by the social-environmental factors such as natural geographic situation, social development level, mean income per capita, mother's schooling, the family relationship with stepmother/stepfather, etc. Reducing prevalence rate of M. R., we need to take the multiple measures and services. It may help the reduction of M. R. prevalence and it is very important to continuously supply iodine salt in these area.

Adult ; Brugada Syndrome ; complications ; physiopathology ; Bundle-Branch Block ; Electrocardiography ; Humans ; Male

Ohjective To study the indications,clinical effect and complications of hysterectomy so as to im- prove therapeutic effect.Methods The clinical data involving 320 cases of hysterectomy in this hospital from 2000 to 2006 were reviewed,and the pathogenesis,operation mode,curative effect and post-operation complications were analysed.Results Patients who received hysterectomy due to benign gynecologic diseases were cured well cliniclly; those who received hysterectomy due to malignant gynecologic diseases or diseases with the tendency of malignant change were cured well in early stage but the effect was not so satisfactory in later stage.The operation mode was de- cided by considering the pathogenesis and individual difference.Conclusion For benign gynecologic diseases,hys- terectomy can be conducted with good effect after conservative treatment becomes ineffective.For malignant gyneco logic diseases,early treatment will bring good resuh,while late treatment will generate not so satisfactory effect.Indi- cations for operation should be controlled strictly for hysterectomy to guard against complications.

Hemophilia B is an X chromosome linked hereditary hemorrhagic disease, which is caused by the lose function mutation of factor IX (FIX), and significantly affects the patients' lifespan and life quality. The severity of hemophilia B depends on the FIX level in the plasma. By referring to the relevant literatures, we reviewed and summarized hemophilia B replacement therapies. Specifically, we focus on recombinant factor IX products on the market and those in the pipeline, especially on the long-acting factor IX drugs, to provide the basis for researches of new hemophilia B drugs.
Factor IX ; genetics ; therapeutic use ; Hemophilia B ; drug therapy ; Humans ; Mutation ; Recombinant Proteins ; therapeutic use

A new method of calculating fractal dimension of short-term heart rate variability signals is presented. The method is based on wavelet transform and filter banks. The implementation of the method is: First of all we pick-up the fractal component from HRV signals using wavelet transform. Next, we estimate the power spectrum distribution of fractal component using auto-regressive model, and we estimate parameter 7 using the least square method. Finally according to formula D = 2- (gamma-1)/2 estimate fractal dimension of HRV signal. To validate the stability and reliability of the proposed method, using fractional brown movement simulate 24 fractal signals that fractal value is 1.6 to validate, the result shows that the method has stability and reliability.
Algorithms ; Electrocardiography ; Fourier Analysis ; Fractals ; Heart Rate ; physiology ; Humans ; Least-Squares Analysis ; Nonlinear Dynamics ; Signal Processing, Computer-Assisted

Objective:To observe the efficacy of acupuncture plus tuina therapy for insomnia.
Methods:Totally 100 eligible patients were randomized into a treatment group (n=51) and a control group (n=49) by using the random number table. The treatment group was intervened by acupuncture at Baihui (GV 20), Fengchi (GB 20), Wangu (GB 12), Shenting (GV 24), Anmian [Extra, locates at the midpoint between Yiming (EX-HN 14) and Fengchi (GB 20)], and Neiguan (PC 6) plus tuina treatment; the control group was intervened by acupuncture alone. For both groups, the treatment was given once a day, 10 sessions as a treatment course, and the efficacies were evaluated and compared after 3 treatment courses.
Results:Of the 51 subjects in the treatment group, 46 cases completed 3 treatment courses, and 17 cases were cured, 18 cases showed marked efficacy, 7 cases were improved, 4 cases had invalid result, and the total effective rate was 91.3%. Of the 49 subjects in the control group, 46 cases completed 3 treatment courses, and 8 cases were cured, 12 cases showed marked efficacy, 14 cases were improved, 12 cases had invalid result, and the total effective rate was 73.9%. The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05).
Conclusion:Acupuncture plus tuina can calm the mind and activate meridian qi in treating insomnia, and it can produce a more significant efficacy than pure acupuncture treatment.

Objective To explore influence of antibiotics and Jiuyi Dan combined with incision-thread-drawing procedure on perianal abscess patients' level of activin A (ACTA) and C-reactive protein (CRP).Methods120 cases of perianal abscess patients in our hospital during March 2015 to December 2016 Coloproctology were selected, they were divided into the experiment group and the control group by random number method.All of patients were taken incision-thread-drawing procedure.Then the experimental group were given nine one antibiotics and Jiuyi Dan, the control group were given antibiotics.The cure rate, 6months after the recurrence rate, average healing time of the wound, and wound edema rate of two groups were observed.Levels of ACTA and CRP expression levels of two groups of patients before and after operation were analyzed.ResultsPatients in the experimental group cure rate was 96.7% higher than that of the control group (P<0.05), the recurrence rate of patients in the experimental group than in the control group, the difference was not statistically significant;the patients in the experimental group the average healing time was (20.67±3.22) d shorter than the average healing time of patients in the control group (29.48±3.15) d, patients in the experimental group wound edema rate of 5% was significantly lower than in the control group 20% (P<0.05);3D ACTA, the expression level of CRP was significantly higher than the preoperative 7 d levels after operation in the two groups (P<0.05);after 7d, the expression level of the two groups of patients with ACTA and CRP were significantly lower than the preoperative level of expression of 7d (P<0.05), experimental group levels of ACTA were significantly lower than the control group, the difference was statistically significant (P<0.05);postoperative 14d patients, ACTA levels of two groups were significantly lower than the levels before operation (P<0.05).ConclusionPerianal abscess can be treated effectively and patients levels of Acta and CRP were obviously dereased by Jiuyi Dan combined with incision-thread-drawing procedure combined, postoperative inflammatory reaction could be importantly alleviated, it was worth clinical promotion.

Objective To analyze the adverse events following immunization(AEFI) in Changning District of Shanghai in 2006,evaluate the safety of vaccines,and provide the evidence for establishing the safe monitoring system of standard vaccination.Methods The AEFI cases were collected and reported by the Vaccine Adverse Events Surveillance System(VAESS).The data were classified as nonserious,serious reaction according to the symptoms and medical records.Results In 2006,178 AEFI cases related to 12 kinds of vaccines from 126459 doses of 19 kinds of vaccines.Among the adverse events reported,amount of nonserious and serious events were 166 cases and 12 ases respectively.The most commonyl reported type of non-serious adverse events were low-grade fever and non-serious local reaction.AEFI cases caused by DTP combined vaccine was in the first rank.Supplementary immunization of DTP combined vaccine had more cases of AEFI than routing immunization.Conclusions Establishing and perfecting the standardized VAESS will improve the susceptibility and the utilization rate of data on AEFI.To reduce the AEFI,we should implement vaccination regulations,distinguish contraindications,and introduce safer vaccines.

Objective To analyze the incidence,risk factors,and impact of intraoperative conversion on the mortality in patients undergoing off-pump coronary artery bypass grafting.Methods This retrospective observational study included 207 patients undergoing off-pump coronary artery bypass grafting.According to whether intraoperative conversion,207 patients were randomly divided into intraoperative unchanged group(191 cases)and intraoperative changed group(16 cases).The incidence,patient characteristics,cause of intraoperative conversion,and its impact on outcome were studied.Results Intraoperative conversion increases odds for mortality to 25.0%,while the other group was 1.0%.The most common cause for intraoperative conversion was hemodynamic disturbances during grafting to the obtuse marginal artery.On multivariate logistic regression analysis,left main disease,mitral regurgitation and higher EuroSCORE II independently predicted intraoperative conversion.Conclusion Intraoperative conversion to on-pump coronary artery bypass grafting is independently associated with higher mortality in patients undergoing off-pump coronary artery bypass grafting.Identification of high risk group of intraoperative conversion may improve the outcome.

Objective To study and analyze the curative effect of linezolid in the treatment of severe pneumonia and the psychological countermeasures. Methods 100 cases of severe pneumonia patients treated in our hospital from March 2015 to August 2016 were selected and randomly divided into the control group and the experimental group. Two groups of patients according to the actual situation of patients with nutritional support and supplement electrolyte based treatment. The control group was treated with levofloxacin and ceftriaxone infusion treatment, the experimental group underwent intravenous linezolid therapy, and psychological care, pay attention to the psychological status of patients and patients, strengthen communication and exchanges, increase confidence in the treatment and the treatment compliance of patients. The therapeutic effects of the experimental group and the control group were compared and analyzed. Results After the corresponding treatment, the number of invalid cases in the experimental group was 4 cases, the number of effective cases was 31 cases, and the number of effective cases was 15 cases. The number of invalid cases in the control group was 10 cases, the effective number was 26 cases, and the effective cases were 14 cases. The effective rate of treatment in the experimental group was 92.0％, which was significantly higher than that in the control group, and the effective rate was 80.0％, with statistical difference (P<0.05). There were no obvious adverse reactions in the experimental group and the control group. The rate of adverse reactions in the control group was 14.0％, significantly higher than that in the experimental group (2.0％), and there was a statistical difference (P<0.05). Conclusion Linezolid is effective in the treatment of severe pneumonia, it can improve the therapeutic effect to a certain extent, and it has high security, it has the significance of clinical promotion.