1.Effects of lumbar sympathetic nerve modulation guided by computed tomography for treating female pelvic limb hyperhidrosis
Xiaomin YANG ; Bing HUANG ; Ming YAO ; Xuyan ZHOU ; Yaping LU ; Jianguo GUO ; Yanbao SUN
Chinese Journal of General Practitioners 2014;13(9):775-777
A total of 17 cases with pelvic limb hyperhidrosis were selected for lumbar sympathetic nerve modulation.The puncture of lumbar sympathetic nerve was guided by computed tomography (CT) through the gap of L2-3 until the needle tip reached the lateral of the second or third lumbar vertebra body and outside of psoas major.A mixture of 1% lidocaine 3 ml and 30% Iohexol injection 0.3 ml was injected.If the diffusion of lidocaine was observed between lumbar vertebra body and psoas major.After 15 min,5 ml of absolute alcohol was injected to modulate the lumbar sympathetic nerve.After 5 min,oximetry-derived perfusion index of toe and sole temperature increased (5.9 ± 1.4) folds and (4.16± 0.89) ℃ on average respectively.Pelvic limb hyperhidrosis was all cured within 6 months and one case recurred after a year.There were no occurrences of complications.Lumbar sympathetic nerve modulation guided by CT may be used for treating female pelvic limbs hyperhidrosis.
2.Clinical efficacy of a locator for puncture under CT examination
Bing HUANG ; Jianguo GUO ; Min YAN ; Ming YAO ; Haoqiang CAO ; Xuyan ZHOU ; Jian HOU ; Yaping LU ; Jianliang SUN
Chinese Journal of Anesthesiology 2012;(9):1094-1095
We designed a locator for puncture under CT examination.Thirty-three patients of both sexesaged 16-76 yr weighing 46-80 kg undergoing bilateral thoracic or lumber sympathetic nerve block under CT examination were enrolled in this study.One side was punctured under the guidance of the locator,while the other side was punctured by conventional technique.The time consumed during puncture,CT scan adjusting time,the deviation of the needle from the targets and the incidence of puncture complications were recorded.The results showed that compared with the conventional technique,with the locator the time consumed during puncture was significantly shorter,the number of attempts and the deviation of the needle from the target were significantly reduced.The procedure was successfully performed on both side in all patients without serious complications such as hemothorax and pneumothorax.
3.Cause analysis and countermeasure of the implementation of basic nursing by practice nursing students
Yimin CAI ; Jiuhong DING ; Wenhui GUO ; Xuyan TAN ; Ren HU
Chinese Journal of Modern Nursing 2017;(6):846-850
Objective To explore the factors affecting implementation of basic nursing by practice nursing students and countermeasures.Methods By cluster sampling, from November to December 2015, 119 nursing students from Xiangtan Medicine & Health Vocational College who had completed their 10-month practice in Hunan Provincial People's Hospital, were selected as objects and were surveyed by a self-designed questionnaire about causes and countermeasures of implementation of basic nursing among practice nursing students.Results The nursing students' negative attitude was the most important cause affecting implementation of basic nursing, which accounted for 0.861 of the original variable; allocating nursing staff more reasonably, establishing an incentive mechanism to overcome occupation burnout, and promoting humanistic care by concerning psychological needs were significant in promoting implementation of basic nursing, each accounting for 0.719, 0.660 and 0.613 of the original variables.Conclusions Nursing educators should strengthen guidance to the nursing students, help them to be more aware of basic nursing, change their negative attitude, allocate nursing staff more reasonably, establish incentive mechanism and pay more attention to their psychological needs.
4.Effect of different sleep positions on the apnea hypopnea index of OSAHS patients
Yimin CAI ; Wenhui GUO ; Jiuhong DING ; Xuyan TAN ; Ren HU
Chinese Journal of Modern Nursing 2017;23(8):1065-1068
Objective To explore the effects of different sleep positions on the apnea hypopnea index (AHI) of obstructive sleep apnea hypopnea syndrome (OSAHS) patients under the state of sleep. Methods Totally 98 OSAHS patients from the ENT clinic and the inpatient department of a tertiary hospital of Changsha from May to July 2015 were selected as the research objects. By using polysomnography detection instrument, the AHI index of patients under different sleeping postures were observed and compared between two groups. Results For 98 patients, the AHI index was (16.51±42.08) in their right lateral position, the AHI index was (20.05±66.11) in left lateral position, AHI index was (22.04±86.39) in supine position, and the AHI index was (53.31±122.88) in prone position. The differences of AHI index in prone position were statistically significant compared with the right lateral position, the left lateral position and supine position (P < 0.05). Conclusions The right lateral position is the best position for OSAHS patients under the state of sleep, and it can decrease upper airway pressure and reduce the sleep apnea and hypopnea during sleep.
5.Single-cell Transcriptome Analysis of Sertoli Cells under High-altitude Environment Reveals Reproductive Toxicity Mechanisms
Yunhua JI ; Linmeng WANG ; Zhen YAO ; Xiao TAN ; Xuyan GUO ; Haozhong HOU ; Bo ZHANG
Medical Journal of Peking Union Medical College Hospital 2024;15(3):587-597
To construct a single-cell transcriptomic map of testicular tissue under hypobaric hypoxia exposure and perform diversity analysis of supportive cells, aiming to provide new insights into the mechanisms of reproductive toxicity for future research. Twenty healthy male mice were randomly divided into a control group ( A single-cell transcriptomic map of testicular tissue was successfully constructed, including 6 samples with a total of approximately 49 027 cells covering 11 cell types. Supportive cells were clustered into 4 subgroups using non-negative matrix factorization algorithm. Subgroup 3 may be more sensitive to hypoxic stimulation and could reduce reproductive cell function damage caused by hypobaric hypoxia by affecting Based on single-cell sequencing technology, the molecular basis and regulatory signals of supportive cells under hypobaric hypoxia exposure is revealed for the first time. It provides an in-depth exploration of the mechanisms of reproductive toxicity induced by hypobaric hypoxia at the single-cell level, offering a new perspective for future clinical research in this field.