Objective:To investigate the status of dyadic coping among patients with lung cancer and their spouses, and explore the related factors of dyadic coping.Methods:A convenience sample of 227 patients with lung cancer and their spouses were selected. The measurements of socio-demographic questionnaire, Dyadic Coping inventory (DCI), the Quality of Relationship index (QRI) and Connor-Davidson Resilience Scale (CD-RISC-10) were used to assess the general information, dyadic coping, relationship satisfaction and resilience, respectively.Results:The DCI score of patients were (3.13±0.89) points; the DCI score of spouses were (3.03±0.93) points; the scores of DCI were significant correlated between patients and their spouses ( r values were 0.248-0.632, P<0.01). The relationship satisfaction ( β values were 0.421, 0.474, P<0.01) and resilience ( β values were 0.374, 0.211, P<0.01) were the significant predictor of dyadic coping. Meanwhile, partner effects for patients′ resilience ( β value was 0.193, P<0.05) and spouse′ relationship satisfaction ( β value was 0.237, P<0.01) were also significant. Conclusions:Moderate dyadic coping were occurred among patients with lung cancer and their spouses. Relationship satisfaction and resilience were the mainly predictors for dyadic coping. To improve relationship satisfaction and enhance resilience might be an effective approach to promote positively dyadic coping.