Objective To conduct dynamic impact failure test of rabbit single vertebra, and make comparison with the static compression experiment, so as to study damage mechanism of the vertebral body under the axial impact. Methods The voltage waveform diagram of the force sensor and the detailed process of the vertebral impact were obtained by the oscilloscope and high-speed photography through the drop hammer dynamic impact experimental device. Results The average static load of the thoracic and lumbar vertebra were 910 N and 947 N, respectively; the average dynamic load of the thoracic and lumbar vertebra were 1 196 N and 1 026 N, respectively; the average thoracic and lumbar dynamic load coefficients were 1.37 and 1.08; under static load, the average stress of the thoracic and lumbar vertebra was 15.28 MPa and 12.51 MPa, respectively; under dynamic load, the average stress of the thoracic and lumbar vertebra was 20.03 MPa and 13.56 MPa; during dynamic impact, the mean longitudinal strain and transverse strain was -0.3 and -0.005 (compression); under dynamic conditions, the destruction energy of vertebrae increased from 0 J to 4.4 J. Conclusions Under dynamic and static experimental conditions, the dynamic load of the same vertebral body was greater than that of the static load; the average dynamic load coefficient of the thoracic vertebra was larger than that of the lumbar vertebra; the equivalent stress of the thoracic vertebra was greater than that of the lumbar vertebra; the axial strain of vertebra under impact was greater than the transverse strain; energy growth of the vertebral body presented a slow at first and then a rapid changing process. The research findings can provide some guidance for prevention and rehabilitation of human vertebral body injury in clinic.

Backgrounds Insomnia is frequent in schizophrenia and is found to be negatively affected by stressful life events,psychotic symptoms and depressive disorder,while the relationship among the four remains understudied in community-dwelling patients with schizophrenia.Objective To analyze the effect of stressful life events on insomnia in community-dwelling patients with schizophrenia,and to explore the mediation effect of psychotic symptoms and depression,so as to provide references for the intervention of insomnia in community-dwelling patients with schizophrenia.Methods From April to June 2023,a sample of 1 105 patients with schizophrenia attending 48 community health centers in Chengdu,Sichuan province and fulfilling the International Classification of Diseases,tenth edition(ICD-10)diagnostic criteria were included.All subjects were assessed using Stressful Life Event Scale(SLEs),Athens Insomnia Scale(AIS),Psychosis Screening Questionnaire(PSQ),and Patient Health Questionnaire Depression Scale(PHQ-9).Spearman correlation analysis was used to determine the correlation among the scales.Then the mediation model was constructed using Smart PLS 4.0,and tested with partial least squares algorithm and Bootstrap techniques.Results 332 patients(30.05%)with community schizophrenia were found to have insomnia.AIS scores in patients with schizophrenia were positively correlated with the scores on SLEs,PSQ and PHQ-9(r=0.165,0.322,0.554,P<0.01).Stressful life events indirectly contributed to insomnia through both separate mediation path and chained mediation path of psychotic symptoms and depressive disorder,and the indirect effect size of 0.102,0.372 and 0.190 was obtained,accounting for 10.46%,38.15%and 19.49%,respectively.Conclusion The stressful life events not only directly exert an impact on insomnia,but also indirectly contribute to insomnia through both the separate and chained mediation effect of psychotic symptoms and depressive disorder.

Objective To investigate the pathological mechanism of spinal injury by axial compression experiment on animal spine, so as to provide references for the treatment, prevention and research of spinal injury. Methods The biomechanical study of rabbit spine segments was performed by axial segment compression experiment. The compression process was recorded and strain analysis was performed by digital image correlation (DIC) technology. Results From the top to the bottom of the spine, the ultimate load and bearing capacity of the segment increased continuously; the average limit load of the corresponding single vertebral body was significantly larger than the segment; the strain of the intervertebral disc in the horizontal and vertical directions was significantly larger than that of the upper and lower vertebral bodies. Conclusions In the process of spine compression, the bearing capacity of the intervertebral disc should be taken into account and the injury of spinal segments is mainly manifested as abnormality of the intervertebral disc. The research findings contribute to the prevention and treatment of spinal compression fractures, as well as the design of related therapeutic instruments and assistive devices.

Objective To establish the precise finite element model of the head and neck based on human anatomical structure, so as to study neck injuries caused by rear impact at different speeds. Methods The model was based on CT scan images of the head and neck of human body. The Mimics software was used to reconstruct the three-dimensional (3D) bone, and the 3D solid ligaments, small joints and other tissues of the neck were improved and meshed by HyperMesh. The generated models included the head, 8 vertebrae (C1-T1), 6 intervertebral discs (annulus, nucleus pulposus and upper and lower cartilage endplates), facet joints (cartilage and joint capsule ligaments), ligaments, muscles, etc. Finally, the model verification and post-collision calculation were completed in the finite element post-processing software. Results The simulation results of the models under axial impact, front and back flexion and lateral flexion were compared with the experimental data to verify the effectiveness of the model. Then post-collision simulation at the speed of 20, 40, 60 and 80 km/h was conducted. At the speed of 20 km/h, there was no damage to the neck. At the speed of 40, 60 and 80 km/h, the ligament was the first to be damaged. As the speed increased, the stress on tissues of the neck increased continuously. At the speed of 80 km/h, the maximum stresses of the dense bone, cancellous bone and annulus of the cervical vertebrae were 226.4, 11.5, and 162.8 MPa, respectively. When the ligament strain reached the limit, tearing began to occur. Conclusions The finite element model of the head and neck established in this study has high bionics and effectiveness, and can be used for studying neck injury analysis in traffic accidents, which is helpful for the diagnosis, treatment and prevention of cervical spine injury to a certain extent.

In unicompartmental replacement surgery, there are a wide variety of commercially available unicompartmental prostheses, and the consistency of the contact surface between the common liner and the femoral prosthesis could impact the stress distribution in the knee after replacement in different ways. Medial tibial plateau fracture and liner dislocation are two common forms of failure after unicompartmental replacement. One of the reasons is the mismatch in the mounting position of the unicompartmental prosthesis in the knee joint, which may lead to failure. Therefore, this paper focuses on the influence of the shape of the contact surface between the liner and the femoral prosthesis and the mounting position of the unicompartmental prosthesis on the stress distribution in the knee joint after replacement. Firstly, a finite element model of the normal human knee joint was established, and the validity of the model was verified by both stress and displacement. Secondly, two different shapes of padded knee prosthesis models (type A and type B) were developed to simulate and analyze the stress distribution in the knee joint under single-leg stance with five internal or external rotation mounting positions of the two pads. The results showed that under a 1 kN axial load, the peak contact pressure of the liner, the peak ACL equivalent force, and the peak contact pressure of the lateral meniscus were smaller for type A than for type B. The liner displacement, peak contact pressure of the liner, peak tibial equivalent force, and peak ACL equivalent force were the smallest for type A at 3° of internal rotation in all five internal or external rotation mounting positions. For unicompartmental replacement, it is recommended that the choice of type A or type B liner for prosthetic internal rotation up to 6° should be combined with other factors of the patient for comprehensive analysis. In conclusion, the results of this paper may reduce the risk of liner dislocation and medial tibial plateau fracture after unicompartmental replacement, providing a biomechanical reference for unicompartmental prosthesis design.
Arthroplasty, Replacement, Knee/methods* ; Biomechanical Phenomena ; Finite Element Analysis ; Humans ; Knee Joint/surgery* ; Knee Prosthesis ; Tibia/surgery*