Objective To observe the clinical value of neutrophil VCS parameters in the patients with zinc oxide toxicosis.Methods The peripheral blood samples from 120 patients with zinc oxide toxicosis,50 patients with bacteria infection and 60 healthy subjects were tested using Coulter LH 750 hematology analyzer.VCS parameters,including mean neutrophil volume (MNV),neutrophil distribution width (NDW),mean neutrophil conductivity (MNC) and mean neutrophil scattering value (MNS),were examined before and after treatment.Results MNV in patients with zinc oxide toxicosis increased significantly compared with those of healthy group and bacterial-infectious group.On the contrary,MNC decreased significantly in the patients with zinc oxide toxicosis compared with that of healthy group and bacterial infection patients.There was significant statistical difference between the two groups (P ＜ 0.01).When the cut-off value is less than 144.70,the sensitivity and specificity of differential diagnosis are 90.83％,98.33％,respectively,higher than those of WBC count and other VCS parameters.The values of MNC in WBC greater than or equal to 10.0 × 109/L group and WBC less than 10.0 × 109/L group were (140.05 ±4.26) and (138.87 ±5.87) respectively.There was no significant difference between the two groups (P ＞ 0.05).The values returned to normal range after treatment for 3 days.Conclusion The MNC of neutrophil may reflect the morphologic change of neutrophils in zinc oxide toxicosis and restore its normal value after treatment,so it can be used as a marker for diagnosis and monitoring of disease.

Purpose To investigate the consistency of the"Standards and guidelines for the interpretation and reporting of sequence variants in cancer"published in 2017 by the Associa-tion for Molecular Pathology(AMP)/American Society of Clini-cal Oncology(ASCO)/College of American Pathologists(CAP).Methods Sixty variants of 26 genes from 11 types of cancer were selected.5 professionals from four hospitals e-quipped with in-hospital NGS detection ability were used to in-terpret the treatment,diagnosis and progenosis respectivly.In the first phase of the study,each researcher rated the variants individually according to their own understanding of the 2017 guideline.In the second phase,the details of the guidelines'e-valuation principles were discussed and interpreted again after reaching a consensus.Results Eleven principles recognized by all participants were summarized as a supplement to interpreta-tion.Fleiss consistency showed that the consistency of interpre-tation of treatment and prognostic significance in the second stage was higher than that in the first phase(κ value was 0.166 vs 0.276,0.014 vs 0.185).The consistency of interpretation of diagnostic significance in the second stage was lower than that in the first phase(κ value was 0.454 vs 0.035).Conclusion There is inconsistency in the clinical interpretation of tumor gene variation among different laboratories.It is feasible for laborato-ries to establish a mutually recognized interpretation system for the clinical diagnosis,treatment,and prognosis of tumors.

Currently, the outbreak of the new coronary pneumonia has entered a critical period of screening, prevention and control.In order to block the transmission of the virus in the radiology department, it is particularly important to effectively protect the medical servant while speeding up the flow of inspection.Based on the basis of notification of the bureau of disease control and prevention, the expert consensus of the CMA and CMDA, and the literature review, combined with the previous practical work experience,this article puts forward the recommendations on the important effect of nursing-technology integrated in the imaging examination of novel coronavirus pneumonia, in order to provide reference for the protection of medical servant in the radiology department at the front line of anti-epidemic.