OBJECTIVE To investigate the drug resistance in Ureaplasma urealytium(Uu)from 2005 to 2007 in Ningbo city and guide rational drug administration in clinics.METHODS Twelve kinds of antibiotics sensitivity test in Uu which was isolated in clinics from 2005 to 2007 were analyzed retrospectivly.RESULTS The detection rate of Uu from 2005 to 2007 was 47.25%,52.66% and 61.94%,respectively.Compared with in 2005(19.96%),the resistance increased obviously to erythromycin and roxithromycin(P0.05).CONCLUSIONS Drug resistance of Uu is changing.It is necessary to monitor the local drug resistance of Uu regularly to guide reasonable administration in clinics.