BACKGROUND:Bioabsorbable miniplates have good achievements after implantation, which have similar effect to the miniature titanium fixation system. Due to its absorbability, the bioabsorbable miniplate cannot exist in the body for a long time, which cannot influence bone stresses, cannot result in bone tissue atrophy, and have fewer complications than traditional metal internal fixations.
OBJECTIVE:To explore and analyze the effects of miniature titanium internal fixation systemversus bioabsorbable miniplates on fracture stability in patients with mandibular fractures.
METHODS:Ninety patients with mandibular fractures admitted at the Department of Stomatology, Hainan General Hospital from January 2013 to May 2015 were enroled. Al the subjects were divided into two groups according to different internal fixations: miniature titanium group and bioabsorbable miniplate group.
RESULTS AND CONCLUSION:At 3 months after internal fixation, the stability rate was significantly higher in the bioabsorbable miniplate group than the miniature titanium group. At 1 year after internal fixation, the range of motion of the processus condyloideus was significantly higher in the miniature titanium group than the bioabsorbable miniplate group. These findings suggest that the bioabsorbable miniplate and miniature titanium internal fixation system both have good clinical outcomes in the treatment of mandibular fractures. The miniature titanium internal fixation system is easy to use and has good stability; the bioabsorbable miniplate can reduce foreign body reaction and prevent osteoporosis, and it has an ideal stability in combination with intermaxilary traction. Therefore, what kind of internal fixations is selected should be determined based on the wilingness and conditions of patients.

OBJECTIVETo investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province.

METHODSSixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing.

RESULTSOf the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30% in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05).

CONCLUSIONRs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.

Alleles ; Asian Continental Ancestry Group ; genetics ; Case-Control Studies ; Cell Cycle Proteins ; genetics ; Gene Frequency ; Genotype ; Humans ; Parotid Neoplasms ; genetics ; Polymerase Chain Reaction ; Polymorphism, Genetic ; Polymorphism, Single Nucleotide ; Transcription Factors ; genetics ; Tumor Suppressor Proteins ; genetics

Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30%in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.

Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30%in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.