Objective To explore the prognostic value of long-time EEG monitoring and the clinical examination index in comatose patients.Methods The long-time EEG monitoring and the modified Glasgow coma scale were done in 26 comatose patients(15 patients were male;11 patients were female;17—40 years old)in acute phase.The complexity of cerebral hemisphere was analyzed by computer.The patients were followed-up for 2 months and evaluated by Glasgow outcome scale.The correlation between the long-time EEG monitoring,clinical examination index and the prognosis of the patients was analyzed.The time- variation of hemisphere complexity and the relationship between prognosis and entropy were observed. Results The specificity(77.8%)and accuracy rate(92.3%)of long-time EEG monitoring in predicting the outcome of the acute comatose patients were higher than those of clinical examination.The EEG index appeared more closed-up with prognosis than clinical examination.The correlation coefficient between the EEG index and the modified Glasgow prognosis scoring was r=0.81(P

Objective To summarize the experience of ES WL and PCNL management for pediatric renal calculi. Methods We retrospectively reviewed the clinical data 105 cases.The series consists of 33 girls and 72 boys.The average age was 8.7 years.Of the 105 children,21(20. 0%) had urinarytract abnormality.68 cases were treated with ESWL,33 with mini-P CNL,and 4 cases with residual stone fragments were treated with min-PCNL and ES WL.Four children underwent open procedures. Results 92 s essions of ESWL were performed in 68 children,57(83.8%)became stone-free.Among them 47 cases ( 69.1 %) were cured by one ESWL session,18 cases(26.5%)had two sessions,three children had three sessions.Two cases who had ureteral steinstras se were rendered stone-free by ureteroscopy.Among 33 children managed by mini- PCNL,24 (72.7%) were cured by one PCNL session,9(27.3%) by two sessions,three pa tients with UPJ obstruction underwent antegrade pyeloureterotomy at the same tim e.Stones were cleared using one PCNL session in 24(72.7%),2 sessions in 29(87.9% ),4 patients were cured with ESWL and mini-PCNL.The overall success rate was 97 .0%.2 of 4 cases in open procedures were performed by means of pyeloplasty,one p atient had residual stone fragments after open surgery. Conclusions ESWL is the first-line treatment for renal calculi in children.PCN L is a option but based on stones status,instrumental and technical conditions. Combining PCNL with ESWL had better outcome.

ObjectiveTo investigate the character of severe cognitive deficit caused by topiramate(TPM) administration in epileptic patients.Methods3 epileptic patients who suffered from severe cognitive deficit following topramate treatment were analyzed.Results and ConclusionTheir verbal functions were often affected especially the fluency of speech, as well as their memory and calculation.

Objective To evaluate the cognitive impairment in epilepsy patients with Topiramate (TPM) or Valproate (VPA) treatment by using WAIS-CR. Methods30 untreated epilepsy patients were divided into two groups receiving TPM or VPA, respectively. All the patients were examined with WAIS-CR before and 3 months after treatment. ResultsThe IQ of TPM group decreased 3 months after treatment (P<0.05). ConclusionTPM may impair the cognitive function in epileptics reflected by decreased IQ.

ObjectiveTo evaluate the cognitive impairment in epilepsy patients with topiramate (TPM) or valproate (VPA) treatment by using visual completion negativity of faces.Methods30 epileptic patients were divided into two groups receiving TPM or VPA, respectively. 15 healthy volunteers were included as controls. Unfamiliar grey-scale photographs of faces (front view) were used as stimuli. Two types of visual stimuli were presented randomly: pictures of complete faces, pictures of incomplete faces (the occluded part was the left-top quadrant).ResultsN170 were elicited in all participants in each condition. The peak latency of N1 elicited by incomplete faces was delayed compared with complete faces in two groups. Under incomplete faces, a decreased and delayed N170 was observed only in TPM group (P<0.05). N170 amplitude and latency did not change in VPA group (P>0.05).ConclusionChanges of N170 is more obvious in patients with TPM than VPA. Cognitive impairment was not present in epilepsy patients with VPA treatment.

Objective To evaluate the treament of central retinal artery occlusion by thrombolysis infusion via super selective ophthalmic artery catheterization.Design Retrospective,observational case series.Participants 21 eyes of 21 patients with CRAO. Methods 21 patients with CRAO were diagnosed by stereoscopic color fundus photography and flouorescein fundus angiography, and were treated by urokinase infusion via super select ophthalmic artery catheterization seldinger technique.Main Outcome Measures Visual acuity and the postoperative complications.Results In the 21 patients,10 had showed the occlusion of ophthalmic arterial trunk by super selective internal carotid artery angiography,the others can be found the appearance of ophthalmic arterial trunk and all patients had undergone thrombolysis therapy successfully.Imaging times of central retinal artery before and after thrombolysis infusion treatment are 38.18?10.86 seconds,12.65?3.30 seconds(t=-11.89,P=0.000).Mean foflow-up time is 3.23?1.26 months.After the treatment,the visual acuity was more than 0.25 in 4 patients,improved to different extent in 9 and remained unchanged in 8. Conclusions Super selective arterial catheterization with thrombolysis for CRAO can improve the visual acuity of the patients,a speedy execution of all internal,neurological,and ophthalmology diagnostic measures;and a prompt therapy are necessary.

ObjectiveTo investigate the characteristics of event-related potential (ERP) N270 and the value of ERP N270 to detect the cognitive function in patients with epilepsy.MethodsThirty-five epileptics were divided into carbamazepine (CBZ) group (n=10), valproate (VPA) group (n=10) and no treatment group (n=15) according to drugs they took, and other 10 healthy subjects were selected as the control group. All subjects were evaluated by Mini-Mental State Examination (MMSE), and ERP was recorded at same time.ResultsAll patients in three groups showed a delayed and smaller N270 than the control group ( P<0.01). VPA group had the lowest N270 amplitude. The amplitude of P300 elicited in the match condition decreased in the VPA group compared with other three groups ( P<0.05), but latency of the VPA group was not different from other three groups.ConclusionCognitive impairment is present in epilepsy patients, and the effect of anti-epileptic drug VPA on ability of patients to process conflict is more evidence than CBZ. The sensitivity of N270 to detect early cognitive impairment in epileptics is higher than P300.

Bone is an active tissue in which the processes of remodeling are continuous to ensure normal bone integrity and strength. Steroids play an important role in regulating bone growth, development and remodeling. Glucocorticoids excess will induce bone damages especially osteoporosis. Otherwise, estrogen and androgen are bone protective steroids in both female and male. To develop a new selective steroid receptor modulator is one of the targets in future study to treat osteoporosis.
Adult ; Androgens ; physiology ; Bone Development ; Bone Remodeling ; Estrogens ; physiology ; Female ; Glucocorticoids ; physiology ; Humans ; Male ; Middle Aged ; Osteogenesis ; Osteoporosis ; prevention & control

Objective To determine the role of erythrocytes immunoadhering in the pathogenesis of the patients with mesangiopro-liferative glomerulonephntis (MsPGN). Methods The immunoadhering functions of erythroeytes and leukoeytcs were measured in 31 patients with no- IgAN,24 patients with IgAN and 30 normal children by rosette tests:RCR,RICR,TRR,TNR and TLR. Results 1. The immunoadhering functions of erythroeytes (RCR and TRR) of the patients with no- IgAN and IgAN were obviously decreased compared to those of control group,but RICR showed no significant difference;2. The immunoadhering functions of leukocytes (TNR and TLR ) of the patients with no- IgAN and IgAN were obviously decreased compared to those of control group;3 The degree of the decreased immunoadhering functions of erythroeytes was correlated respectively with that of the immunoadhering functions of leukoeytes. Conclusions The decrease of the function of erythroeyte and leukocyte immunoadhering plays an important role in the pathogenesis in patients with MsPGN. These rosette tests may be used in clinic.