Female ; Humans ; Hydrogen ; Hypoxia-Ischemia, Brain ; diagnosis ; Infant, Newborn ; Magnetic Resonance Spectroscopy ; methods ; Male

OBJECTIVE:To improve the rational and scientific drug purchase quantity planned by hospital pharmacy. METH-ODS:The deficiency in present drug purchase module of hospital information system(HIS)was analyzed;the formula of planned purchase quantity was improved by incremental coefficient method,ABC analysis method and VEN analysis method. The high and low stored values and packaging volume were set to adjust planned drug purchase quantity. Based on the computer program,a one-key-getting procedure was quasi established,and five typical drugs were selected for simulation. RESULTS:Based on previous formula,the parameters representing change trend,incremental coefficient k1 and inventory coefficient k2 were added in new formu-la. The one-key-getting procedure could calculate the quantity of all drugs by simply entering the planning cycle N1 and the safe peri-od N2 of the some category drugs into the system. After simulated operation practice,compared with pre-improvement,the occupa-tion of funds was significantly decreased and the quantity of drug was rounded off according to package in post-improvement. CON-CLUSIONS:Through function improvement of drug purchase module in HIS and the quasi establishment of one-key-getting pur-chase mode,planned drug purchase quantity is more reasonable,scientific and accurate. It ensures the clinical drug supply in time without causing a backlog,and effectively reduces the cost of manpower,material and capital.

Thinning and atrophy of sclerotic tissues play an important role in the development of high myopia. High myopic eyes had the thickest sclera at the posterior pole and the thinnest sclera at the equator. Most clinical studies found that scleral thickness was negatively correlative with the axial length. Patients complicated with posterior staphyloma had even thinner sclera, and its height was negatively related with the scleral thickness. At present, the main measurement methods for scleral thickness of high myopic eyes include histological measurement, enhanced depth imaging optical coherence tomography (OCT), and swept-source OCT. Following the development of OCT technique, it gradually becomes feasible to carry out studies on sclera thickness in mildly and moderately myopic populations, which is helpful to illuminate the mechanism of action of sclera on the onset and progression of high myopia.

Objective:To explore the associations of menopause with cardiovascular disease (CVD) and related metabolic disorders (including hypertension,diabetes or higher blood sugar,obesity,dyslipi-demia)in Chinese females aged 45 -59 years .Methods:Data were acquired from a national cross-sectional survey conducted in 201 3,China,which was also the second follow-up survey of China Health and Retirement Longitudinal Study (CHARLS).In the study,4 702 Chinese perimenopausal women aged 45 -59 years were enrolled,including 1 769 premenopausal women and 2 933 postmenopausal women.Information was collected from questionnaires of health status and functioning and physical exa-mination.General liner models were employed to calculate age-adjusted or age-and-body-mass-index-adjusted or multiple-factor-adjusted means and their 95% confidence intervals (95% CIs)of cardiovas-cular risk factors (CRFs).The comparisons of CVD and its risk factors according to menopausal status, and calculation of adjusted odds ratios (ORs)and their 95%CIs for the associations of menopause with CVD and its risk factors were performed by multivariate Logistic regression models separately.Results:After adjustment for age and other confounders (including body mass index,marriage,education,current smoking,drink alcohol more than once per month),statistically significant associations of menopause with cardiovascular disease,which referred to having a history of heart disease or stroke in this study, were observed in the participants (OR =1 .34,95% CI:1 .04 -1 .74);prevalence of hypertension (OR =1 .42,95%CI:1 .1 0 -1 .84),prevalence of CRFs clustering number≥2 (OR =1 .31 ,95%CI:1 .02 -1 .68)and average waist circumference level (87.1 1 cm,95%CI:86.81 -87.42 cm in post-menopausal group vs.86.41 cm,95%CI:85.99 -86.84 cm in premenopausal group)were presented higher in postmenopausal group,compared with the premenopausal one.However,diabetes or higher blood sugar (OR =0.96,95%CI:0.60 -1 .52),dyslipidemia (OR =0.84,95%CI:0.59 -1 .20) and obesity (OR =1 .06,95%CI:0.86 -1 .32)were not shown significantly statistically related to me-nopause,after excluding effect of age and other confounders.Conclusion:Postmenopausal women in China had worse CRFs profile than the premenopausal ones,which implied menopause might aggravate the CRFs epidemic and increase the risk of cardiovascular disease beyond effects of aging,which would increase the CVD burden during and after their middle ages.

Objective To study the clinical significance of urinary mtcroprotems examination on early diagnosis of kidney damage of children with obesity. Method Urinary microproteins were tested in 40 obese children by enzyme - linked immunosorbent assay and 50 healthy children as controls. Results Urinary microprotem examination were abnormal in 8 obese children. Albumin in 5 cases increased, and transferrin(TRF) with retinol-binding protein in 1 case increased meanwhile. TRF in 3 cases increased. One case was abnormal by kidney biopsy.Conclusion Urinary microprotem examination was the sensitive index in early diagnosis of obesity-related glomerulopathy in children.

Objective To investigate the distribution of four common chronic diseases including essential hypertension, type 2 diabetes, coronary heart disease (CHD) and stroke, and their related risk factors in fertile and menopausal women. Methods Census data were collected by questionnaire, physical examination and laboratory examination in females older than 40 yrs in rural areas of Fangshan District, Beijing. Student's t test, chi-square test and logistic regression model were used. Results The prevalence rates of essential hypertension, type 2 diabetes, CHD, stroke in menopausal women (64.2%, 13.2%, 5.9%, 48.1%) were higher than those in fertile women (41.4%, 6.9%, 1.7%, 15.1%)with statistically significant differences (P

Objective To comparO thO clinical OffOct of capOcitabinO combinOd with oxaliplatin or irinotOcan in thO trOatmOnt of colorOctal cancOr with livOr mOtastasis. Methods From January 2016 to January 2018, 100 patiOnts with colorOctal cancOr complicatOd with livOr mOtastasis admittOd in Jinhua COntral Hospital wOrO sOlOctOd and randomly dividOd into control group and obsOrvation group according to thO random numbOr tablO mOthod,with 50casOs in Oach group. Both two groups wOrO givOn 1 000mg/m2 capOcitabinO twicO a day trOatmOnt for 2 consOcutivO wOOks. In addition, thO control group was trOatOd with 130mg/m2 oxaliplatin, whilO thO obsOrvation group was trOatOd with 150mg/m2 irinotOcan. ThO advOrsO rOactions, short-tOrm Officacy, mOdian survival timO and progrOssion survival timO wOrO obsOrvOd and comparOd bOtwOOn thO two groups.Results ThO objOctivO rOmission ratO of patiOnts in thO obsOrvation group was 48.00% , which was significantly highOr than 36.00% in thO control group (χ2 =7.253,P<0.05).ThO disOasO control ratO of thO obsOrvation group was 80.00% , which was significantly highOr than 66.00% of thO control group (χ2 =9.273,P<0.05).ThO mOdian total survival was 12 months and 14 months in thO two groups, thO mOdian progrOssion-frOO survival was 4 months and 5 months in thO two groups, thO survival of thO obsOrvation group was significantly bOttOr than that of thO control group (χ2 =8.676,P<0.05). ThO incidOncO ratO of diarrhOa in thO obsOrvation group was 14.00% , which was significantly lowOr than 34.00% in thO control group ( χ2 =5.967, P<0.05).ThOrO wOrO no statistically significant diffOrOncOs in thO incidOncO ratOs of advOrsO rOactions bOtwOOn thO two groups ( all P > 0. 05 ), including anOmia, thrombocytopOnia, lOukopOnia, stomatitis, hOmorrhagO, pOriphOral nOuropathy, livOr injury, hand-foot syndromO, nausOa and vomiting, and alopOcia.Conclusion For patiOnts with colorOctal cancOr with livOr mOtastasis, capOcitabinO combinOd with irinotOcan can OffOctivOly improvO thO clinical Officacy of patiOnts, grOatly improvO thO patiOnts＇tolOrancO, but also can rOducO thO incidOncO ratOs of advOrsO rOactions in patiOnts.Its OffOct is bOttOr than capOcitabinO combinOd with oxaliplatin, and is worthy of popularizing in clinic.

Objective By observing the curative effect of Yangxue Zhiyang Capsule (YZC) on guinea pigs and senile rats, therapeutic effect of YZC for senile pruritus and its mechanism was assessed. Methods Animal models with pruritus induced by exogenous histamine were used to observe the effect of YZC in relieving itching. Senile rat models of blood deficiency induced by acetophenylhydrazine (APH) were applied to measure the effect of YZC on red blood cells (RBC) counting, blood hemoglobin (Hb), plasma estrogen (E2), testosterone (T) and proesterone(PO), sexual organ weight and the amount of sebaceous gland and its secretory function. Results YZC could raise the itching threshold of guinea pigs with pruritus, elevate RBC amount and Hb content, increase E2,T and PO levels, elevate the weight of sexual organs and the number of sebaceous glands, and promote the secretory function of sebaceous glands in rats with blood deficiency. Conclusion YZC has good effect in relieving itching of guinea pigs with pruritus and nourishing blood of rats with blood deficiency by raising the levels of sex hormones, increasing the number of sebaceous glands and stimulating sebaceous gland secretion.

Objective To compare the therapeutic effects of minimally invasive percutaneous nephrolithotomy(MPCNL) and retroperitoneal laparoscopic ureterolithotomy(RLUL) in the management of impacted upper ureteral calculi.Methods A total of 72 patients with unilateral impacted upper ureteral calculi were treated with MPCNL(n=45) or RLUL(n=27).The operation time,clearance rate of the stone,and the incidence of postoperative hyperpyrexia were statistically analyzed.Results All the operations were completed.As compared to the RLUL group,the MPCNL group had a significant shorter operation time [(43?9) minutes vs(69?17) minutes,t=-11.564,P=0.000].On the day after the operation,both the groups showed a stone clearance rate of 100%.No significant difference was detected in the rate of postoperative hyperpyrexia between the two groups [13.3%(6/45) vs 11.1%(3/27),?2=0.000,P=1.000).The patients were followed up for 1 to 24 months(mean,8 months),none of them developed ureteral stricture or recurrent stones during the period.Conclusion Both MPCNL and RLUL are safe,effective,and feasible for impacted upper ureteral calculi.