Objective To evaluate salivary gland function in primary Sjgren′s syndrome (pSS) objectively,and highly sensitive and significant indicators were chosen by correlative analyses of parameters of salivary gland scintigraphy with the histopathologic grading of labial biopsy in pSS.Methods Salivary gland scintigraphy was preformed using 99m TcO - 4 in 78 patients with pSS and 20 normal controls.Functional parameters of the parotid (Par) glands were calculated.The results of pSS groups were compared with normal controls.All patients with pSS underwent labial biopsy after imaging and Spearman rank correlation test was used for scintigraphy functional parameters and histopathologic grading.Results ① The maximum accumulation ratio (MAR) of Par gland significantly decreased with histopathologic grading increase ( r = -0 649, P