Objective To evaluate the changes of IL-1β and IL-lra in hippocampus of rats with frequent febrile seizures(FS).Methods 21-day-old male Sprague-Dawley(SD)rats were randomly divided into 3 groups:normal control group(NC group),hyperthermic control group(HC group)and febrile seizures group(FS group).IL-1β and IL-1ra levels in hippocampus of these rats were determined by ELISA methods,IL-1β mRNA and IL-1ra mRNA levels in hippocampus were measured by RT-PCR.Results IL-1β mRNA and protein levels in hippocampus of rats in FS group were significantly higher than those in NC group and HC group(P＜0.01,P＜0.05).IL-1ra mRNA and protein levels in hippocampus of rats in FS group were significantly higher than those in NC group and HC group(P＜0.01,P＜0.05),too.IL-1ra/IL-1β protein ratio showed no significant difference among 3 groups.Conclusion Frequent FS can cause the increase of IL-1β and IL-lra mRNA and protein levels in hippocampus,suggesting that IL-1β and IL-1ra may be involved in the pathogenesis of hippocampal neuron damage in FS rat.

Hemorrhagic shock and encephalopathy syndrome (HSES)is a devastating disease in infants which was first proposed by Levin in 1983. The main clinical manifestations of HSES are associated with acute onset of high fever,diarrhea,rapidly followed by convulsions,unconsciousness,bleeding tendency,shock and multiorgan dysfunction. The pathological manifestations include punctate bleeding,necrosis or inflammatory changes in multiple organs. The etiology of this syndrome is unknown,and the prognosis is poor. Despite intensive treatment,the fatality rate is still high and the survival is often associated with severe neurological sequelae. At present,there is no effective treatment for this disease,and mainly early symptomatic and supportive treatment can be obtained.