Objective:To discusses the medication rules of Professor Yuan-Shaoying in the treatment of chronic prostatitis (CP), and to explore the relationship between TCM Syndrome Types and UPOINT system classification. Methods:The TCM syndrome type frequency, UPOINT system classification frequency, drug frequency, four Qi and five flavor meridian tropism frequency were counted by using TCM inheritance auxiliary platform (v2.5). The TCM Syndrome Types and TCM of each type in UPOINT system were obtained according to complex system entropy clustering.Results:A total of 123 prescriptions were included, involving 9 TCM syndrome types, of which the top five were dampness heat stasis syndrome, qi stagnation and blood stasis syndrome, kidney deficiency and blood stasis syndrome, dampness heat downpour syndrome, liver depression and kidney deficiency syndrome. The majority of patients with damp heat stasis syndrome were U-type (urination symptoms) and I-type (infection symptoms), liver depression and kidney deficiency syndrome were mainly p-type (psychological symptoms) and N-type (neural symptoms), most of qi stagnation and blood stasis syndrome were O-type (organ-specific symptoms) and T-type (pelvic floor muscle pain). There were 123 kinds of herbs, and the top five are Shixiaosan ( Wulingzhi + Puhuang), Yanhusuo, licorice, wild grape root and Salvia miltiorrhiza. The drugs mainly include promoting blood circulation and removing blood stasis, clearing heat and tonifying deficiency. The channels of meridian are mainly liver, spleen and kidney. Cold and flat properties are common, while bitter, sweet and pungent are common. According to the U-type classification, the Chinese medicines for clearing heat and detoxification, promoting blood circulation and removing blood stasis were the main drugs, and the top three Chinese medicines were wild grape root, snake berry and licorice root; the P-type was mainly composed of soothing the liver and relieving depression, promoting blood circulation and tonifying the kidney; the top three used frequency were bupleurum, licorice and Paeonia Alba; the O-type was mainly used for promoting Qi, promoting blood circulation, dredging collaterals and relieving pain, and the top three were used frequently. According to the I-type, the main TCMs were clearing heat and activating blood circulation, removing dampness and removing dampness. The top three kinds of TCM were wild grape root, Shixiaosan and liquorice. The N-type was mainly composed of soothing the liver and dredging collaterals, promoting blood circulation and tonifying the kidney, and the top three were bupleurum, Sparganium and Salvia miltiorrhiza; the T-type was mainly the TCM of promoting blood circulation and relieving pain, tonifying liver and kidney; and Yanhusuo, Shixiaosan and Salvia miltiorrhiza were the top three Chinese medicines used frequently. Conclusions:Professor Yuan-Shaoying often takes "promoting Qi, activating blood circulation and removing blood stasis "as the main treatment principle of CP, focusing on regulating the three meridians of liver,spleen and kidney. The relationship between UPOINT system and TCM syndrome types were warranted in further.

This paper summarized Professor LI Yueqing's clinical experience in treating prostate cancer by stages from the perspective of deficiency and stasis. It is believed that the onset of prostate cancer is due to kidney deficiency， while blood stasis is the core pathogenesis， and dampness-heat， phlegm-turbid， and cancer toxins are the key pathological factors in the progression of the disease. The pathogenesis in the early stage of the disease is kidney qi depletion and dampness， heat and phlegm coagulation； in the middle stage， it is spleen and kidney depletion， phlegm coagulation and blood stasis； and in the late stage， the pathogenesis changes into yin deficiency and essence depletion， and stasis-turbid toxin obstruction. For treatment， the basic principle is to supplement and boost kidney qi， enrich and nourish the kidney yin. The main treatment methods are draining dampness， dissolving phlegm， dispelling stasis， clearing heat and resolving toxins， and the method of invigorating blood and dispelling stasis runs through the whole course of treatment. In the early stage， radical treatment is mainly used， and Longshe Yangquan Decoction （龙蛇羊泉汤） with modifications is supplemented to clear and drain dampness and heat. In the middle stage， androgen deprivation therapy is the basic treatment， and Bushen Tongqiao Decoction （补肾通窍汤） with modifications is used in combination to nourish the spleen and kidney， dissolve phlegm and dispel stasis. In the late stage， Dabuyin Pills and Liuwei Dihuang Pills （大补阴丸合六味地黄丸） with modifications is mainly used to enrich yin and supplement essence， resolve toxins and dissolve stasis， and prevent cancer recurrence.

ObjectiveTo systematically review the intervention effect of Chinese medicine on the structure and function of testicular Sertoli cells in animal models of impaired spermatogenesis. MethodThe databases， such as China National Knowledge Infrastructure （CNKI），VIP，Wanfang Data，EMbase，and Pubmed，were searched for experimental studies on the effect of Chinese medicine on the structure and function of testicular Sertoli cells in animal models with impaired spermatogenesis. The included studies were evaluated for risks of bias，and the outcome indicators were analyzed with RevMan and Stata software. ResultThirty studies were included，involving 37 randomized controlled trials （RCTs）. As indicated by the Meta-analysis results， compared with the model group，Chinese medicine increased sperm density（SMD=2.42，95% confidence interval（CI）［1.47，3.37］，P<0.000 01）， promoted sperm motility（SMD=2.35，95%CI ［1.70， 2.99］，P<0.000 01）， up-regulated the protein and mRNA levels of Vimentin （related to Sertoli cell cytoskeleton）， elevated the levels of Occludin and Claudin-11 （related to tight junction of blood-testis barrier）， boosted the levels of β-catenin and N-cadherin （related to adherens junction of blood-testis barrier）， raised the level of connexin 43 （Cx43， related to gap junction of blood-testis barrier）， improved the function of Sertoli cells， increased the serum content of Inhibin B （INHB）， and up-regulated the levels of testicular follicle-stimulating hormone receptor （FSHR）， INHB mRNA， androgen-binding protein （ABP） mRNA， transferrin（TF），stem cell factor（SCF），SCF mRNA，glial cell line-derived neurotrophic factor （GDNF），GDNF mRNA，bone morphogenetic protein 4（BMP4），and BMP4 mRNA （P<0.05）. ConclusionChinese medicine can effectively increase sperm density and motility of animal models of impaired spermatogenesis，and improve the structure and function of testicular Sertoli cells. However，affected by the quality of the included studies，the above conclusion needs to be further verified by relevant high-quality studies.