Objective To analysis the clinical characteristics and the correlative factor of kidney lesion in multiple myeloma.Methods Analysis of statistics in clinical characteristics and results of laboratory of kidney lesion were carried out in myeloma patients.Results The incidence of kidney lision was 39.1%(18/46),the most common kidney lesion was chromic renal failure.There was a significant correlation between the quantity of bone marrow plasmacyte or urine Bence-Jones protein and renal functional lesion( P