Objective:To explore the current status of physical frailty in elderly patients with chronic obstructive pulmonary disease (COPD) and analyze its influencing factors.Methods:A total of 278 COPD patients who were admitted to Geriatric Medicine Center of Xinjiang Uygur Autonomous Region People's Hospital from February 2018 to February 2020 were selected as the research objects by the convenient sampling method. FRAIL Scale was used to assess frailty status of the patients. General information questionnaire and clinical questionnaires were used to investigate. Ordinal Logistic regression model was used to analyze the influencing factors of frailty in elderly COPD patients.Results:A total of 278 questionnaires were issued and 260 valid questionnaires were returned, including 120 cases without frailty, 97 cases in early frailty and 43 cases in frailty. The results of ordinal logistic regression analysis showed that age [ OR=1.324, 95% CI: (1.011-1.632) ], whether exercise regularly [ OR=0.265, 95% CI: (0.004-0.765) ], whether lack of nutrition [ OR=1.335, 95% CI: (0.258-1.985) ], with or without comorbidities [ OR=1.654, 95% CI: (0.521-1.865) ], lung function classification [ OR=2.356, 95% CI: (1.520-3.690) ], whether inflammation [ OR=1.258, 95% CI: (0.024-1.821) ] and prolonged length of stay in hospital due to exacerbation of COPD in the past 1 year [ OR=0.854, 95% CI: (0.214-1.662) ]were influencing factors of frailty in elderly COPD patients (all P<0.05) . Conclusions:The frailty of elderly patients with COPD is affected by factors such as age, exercise, nutritional status, length of stay in hospital, lung function, inflammation and complications. Nursing staff should prevent frailty and delay the progression of frailty in COPD patients through effective intervention.