1.Prenatal diagnosis of microcephaly due to CTNNB1 frameshift variation: a case report
Haiyu LI ; Weifang TIAN ; Yanhua DONG ; Yangyang WANG ; Handuo WANG ; Jia PENG ; Bo YANG ; Xueyin CUI ; Shihong CUI ; Ling LIU
Chinese Journal of Perinatal Medicine 2024;27(5):417-420
This article reported a case of neurodevelopmental disorder accompanied by spastic diplegia and visual impairment with the manifestation of small fetal head circumference. Prenatal ultrasonography performed at 33 +5 weeks of pregnancy revealed small fetal head circumference (-2.61SD) and oligohydramnios. Whole-exome sequencing identified a heterozygous frameshift variation of c.1623_1624insA (p.R542Tfs*30) in the CTNNB1 gene (NM_001904.4) of the fetus. No phenotypic abnormalities or corresponding gene variations were detected in the parents, suggesting it was a de novo variation. Based on the clinical manifestations, the fetus was diagnosed with a neurodevelopmental disorder accompanied by spastic diplegia and visual defects. Following genetic counseling, the pregnant woman chose to terminate the pregnancy.
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