Based on the brief introduction of the concept of evidence - based medicine and the importance of its education, the paper analyzes the advantages of launching this kind of education in medical library. Contents and modes are described in detail. It proposes va-rious forms of education should be carried out according to different user groups, so as to further promote the development of evidence-based medicine education.

OBJECTIVE:To find out potential financial risk in the listed Chinese pharmaceutical companies and to provide rec-ommendations. METHODS:The Z-score established with Altman E was adopted to classiy and analyzed empirically 143 listed phar-maceutical companies in China during 1998-2013 by sub-sectors(medical devices,pharmaceutical commercial,biological products chemical raw medicine,traditional TCM). The effects of some data in annual reports on Z-score were validated by using stepwise regression. RESULTS:The result showed that the average Z-score values percentage of the best 3 companies were 90.95%,47.96%and 41.25%,respectively,from 1998-2013;while for the worst 3 companies,the values were 0.80%,1.14%and 1.21%,respective-ly. At the same time,the financial situations of chemical raw medicine companies were the worst among 5 sub-sectors,of which dur-ing 2004-2006,the constituent ratios of companies in“Distress”zones went over 50.00%,which were 60.00%,55.20% and 53.60%,respectively. If counted by calendar year,the market value per share of 10 years and float of 9 years significantly affected the Z-score values(P<0.05);if counted by listed year,the market value per share of 15 years significantly affected the Z-score val-ues. CONCLUSIONS:Although major pharmaceutical companies have good financial status,financial crisis still exists in some companies. Especially,the financial situations of chemical raw medicine companies should not be neglected. The government should pay more attention to share price in order to prevent financial crisis which was induced by stock bubbles;at the same time,supervi-sion system should be established to evaluate the financial situation of listed pharmaceutical companies,even for all listed companies.

OBJECTIVE:To study the effects of ritonavir on the pharmacokinetics of sufentanil in rabbits. METHODS:24 rab-bits were randomly divided into 2 groups,with 12 rabbits in each group. Trial group was given ritonavir 10 mg/kg by gavage and then injected sufentanil 2 μg/kg intravenously after 5 min. Control group was given equal volume of normal saline by gavage and then injected sufentanil 2 μg/kg intravenously. Arterial blood samples 0.3 ml were taken before gavage and 0,0.25,0.5,1,2,3, 4,6,8,10,12,14,24 h after intravenous administration. The plasma concentrations of sufentanil were determined by LC-MS/MS,and DAS 2.0 software was adopted to calculate pharmacokinetic parameters. RESULTS:The pharmacokinetic change of sufen-tanil conformed to two-compartment model in 2 groups. The pharmacokinetic parameters of sufentanil in control group vs. trial group were that t1/2 were(22.0±6.59)and(26.4±1.41)h;MRT0-24 h were(8.6±2.08)and(12.1±3.70)h;AUC0-∞ were(16.1± 5.17)and(38.1±12.95)mg·h/L,respectively. There was statistical significance in MRT0-24 h and AUC0-∞ between 2 groups(P<0.05). CONCLUSIONS:Ritonavir can elevate distribution of sufentanil in rabbits,and prolong retention time of sufentanil.

Objective To discovery the difference about TCM constitution between urban and rural area from the survey results performed in 2 communities of Beijing. Methods 9 standard survey scales of Chinese Medicine Constitution and four diagnostic methods of TCM were performed to identify body constitution of 161 people whose age are almost 64 years; The distribution of total constitution and the constitution distribution of same sex were further analyzed. Results The distribution of 9 TCM body constitution were different between town and country, the gentleness type distribution in country was lower than city (24.68%, 51.19%) ; Qi-depression type distribution was significant higher in country than city (44.16%,5.95%) . Conclusion Most of people in the country were yang-deficiency type and qi-depression type body constitution, the distribution of which affected by gender and age, etc.

Objective To observe the effect of comprehensive rehabilitation on POEMS syndrome during sequel period. Methods Two cases of POEMS syndrome with multiple peripheral nerve injury as the main manifestation received physical therapy, occupational therapy, acupuncture, surface electromyography biofeedback and other comprehensive rehabilitation treatment. Results After treatment, the muscle strength, trunk balance, standing balance ability, activities of daily living (ADL) improved. The score of Berg Balance Scale increased from 18 to 28 in the first case, the modified Bathel Index increased from 55 to 70 in the second case. Conclusion Comprehensive rehabilitation can improve the function of patients with POEMS syndrome during sequel period, and surface electromyography biofeedback plays an im-portant role.

Objective To compare the reliability and validity of job content questionnaire (JCQ1.0) and effort-reward imbalance (ERI) questionnaire in job stress study for civil aviation staff. Methods One hundred and ten individuals were investigated by JCQ1. 0 and ERI questionnaire for job stress, and their reliability and validity were evaluated. Results In JCQ1. 0, high-strain, active, passive,and low-strain workers accounted for 23.6%, 20. 9%, 24. 5%, and 30. 9%. Job stress was found in 59. 1% in ERI. The internal consistency reliabilities (Cronbach α) of the 3 dimensions in JCQ1.0 ranged from 0. 10 to 0. 51, and the split-half reliability was 0. 50; however, the internal consistency reliabilities ( Cronbach α) of the 3 dimensions in ERI ranged from 0. 35 to 0. 79, and the split-half reliability was 0. 78.Most items of both questionnaires showed good construct validities. In factor analysis, total variance contribution was 64. 62% ( JCQ1. 0 ) and 58.08% ( ERI ), respectively. Conclusion ERI may be a reliable and valid tool of job stress assessment; however, JCQ1.0 seems to need further modification.

Community nurses are the main forces of community heaLth service, whose skiLL LeveLs directLy affects the performance of traditionaL Chinese medicine (TCM) nursing. This articLe reviews the research reLated to TCM nursing training in community nurses and proposes countermeasures accordingLy in order to provide a reference for TCM nursing training in community nurses.

ObjectiveFrom the changes of expression of cold-inducible RNA-binding protein (CIRP) in rats with traumatic brain injury under mild hypothermia treatment with Shenfu decoction as a subsidiary, to speculate the mechanism of protective effect of the decoction on the injury.Methods Ninety Sprague-Dawley (SD) rats were divided into three groups by random number table: non-transfection control group, adenovirus mediated immune flourescent reverse transcription virus group (blank AD5-GFP transfection group) and adenovirus mediated immune flourescent reverse transcription virus carrying CIRP silent expression gene group (AD5-GFP-CIRP-SiRNA transfection group), 30 rats in each groups. Then, each group was subdivided into three subgroups: model group, traditional Chinese medicine (TCM) low and high dose groups, 10 rats in each subgroup. After the mild hypothermia treatment for 48 hours, in the TCM low dose group and high dose group, a dose of TCM 1 mL/kg and 5 mL/kg was injected via a tail vein into the rat respectively, while in the model group, 1 mL/kg normal saline was injected into the same vein, once a day for consecutive 2 days in all the groups. Before modeling in the blank AD5-GFP transfection group and AD5-GFP-CIRP-SiRNA transfection group, virus transfection models were reproduced at first by one-time intrathecal injection of 0.1 mL AD5-GFP and 0.1 mL (1×1010 pfu/mL) AD5-GFP-CIRP-SiRNA virus vector respectively, and in model group, 0.1 mL normal saline was given. The rat cortex, hippocampus and hypothalamus part were collected, the brain cell apoptosis was detected by transferase-mediated deoxyuridine triphosphate-biotin nick end labeling (TUNEL), the CIRP mRNA expression in the cortex, hippocampus and hypothalamus part was measured by reverse transcription-polymerase chain reaction (RT-PCR), the protein expressions of rat sarcoma protein Raf, Ras, extracellular signal-regulated kinase (ERK), phosphorylation ERK (p-ERK), mitogen activated protein kinase (MEK), p-MEK were determined by Western Blot.Results The brain tissue cell apoptosis indexes (AI) in the cortex, hippocampus and hypothalamus part in TCM low, high dose group of non-transfection control and blank AD5-GFP transfection group were lower than those in model group, and the expressions of CIRP mRNA were higher than those in model group, there were no significant differences in AI and CIRP mRNA in the cortex, hippocampus and hypothalamus between model, TCM low and high dose groups of AD5-GFP-CIRP-SiRNA transfection group, but AI was significantly higher and CIRP mRNA was significantly lower than that in corresponding subgroups of AD5-GFP transfection control group and blank AD5-GFP transfection group. Western Blot detection showed that: Raf/Ras, p-MEK/MEK protein expressions revealed no statistical significant differences in different parts of each group (allP > 0.05), the p-ERK/ERK protein expression in the cortex, hippocampus, and hypothalamus part was significantly lower in TCM low and high dose group than that in the model group of non-transfection control group and blank AD5-GFP transfection group, the degree of descent in the TCM high dose group being more significant (the cortex: non-transfection control group was 7.2±1.0 vs. 15.3±1.8, AD5-GFP transfection group was 8.1±0.7 vs. 16.2±1.5; hippocampus part: non-transfection control group was 6.6±0.8 vs. 14.7±2.0, AD5-GFP transfection group was 6.8±1.0 vs. 14.9±1.3; hypothalamus part: non-transfection control group was 9.4±1.1 vs. 12.7±1.7, AD5-GFP transfection group was 10.6±1.3 vs. 9.4±1.1, allP < 0.05). There were no significant statistical differences in p-ERK/ERK protein expression in above brain parts between AD5-GFP-CIRP-SiRNA transfection subgroups (allP > 0.05).Conclusions The Shenfu decoction used in rats with brain trauma under treatment of mild hypothermia is possibly by promoting CIRP over-expression, lowering ERK expression and inhibiting the initiation of signal transduction of the secondary transcription factor phosphorylation, thereby the neural cell apoptosis is decreased and play a subsidiary role of anti-apoptosis of mild hypothermia.

Objective:To construct a traditional Chinese medicine nursing technology training program for community nurses.Methods:This research drafted the outline of the traditional Chinese medicine nursing technology training program for community nurses through the preliminary investigation and group discussion. The Delphi expert consultation was used to conduct consultation to 15 experts to finally determine the traditional Chinese medicine nursing technology training program for community nurses.Results:The positive coefficients of 15 experts in two rounds of Delphi expert consultation were 80.00% and 93.75%, and the authority coefficients were 86% and 87%, respectively. The Kendall's W of the second-level and third-level indicators of this program were 0.428 and 0.382 respectively with a statistical difference (both P<0.01) . The final traditional Chinese medicine nursing technology training program for community nurses included 5 first-level indicators, 18 second-level indicators, and 111 third-level indicators. Conclusions:The traditional Chinese medicine nursing technology training program is reliable, scientific and credible, and can provide theoretical guidance for community nurses in traditional Chinese medicine nursing technology training.

Objective:To construct a standardized training program for newly recruited nurses in Class ⅢGrade A traditional Chinese medicine (TCM) hospitals based on the theory of post competency.Methods:From April to July 2020, the consultation questionnaire was developed on the basis of literature review and the expert group discussion. Through the Delphi method, two rounds of consultations were conducted with 20 experts from Class Ⅲ Grade A TCM hospitals and the university of TCM in Zhejiang Province to construct the standardized training program for newly recruited nurses in TCM hospitals based on the post competency. The positive coefficient, the authority coefficient, and the coordination coefficient of the experts were calculated.Results:In the two rounds of consultations, the experts' positive coefficients were all 100%, and the authority coefficients were both 0.896, and the Kendall coordination coefficients were 0.177 and 0.215 respectively, ( P<0.01) . The final standardized training program for newly recruited nurses in TCM hospitals based on the post competency included 5 first-level indicators, 17 second-level indicators, and 106 third-level indicators. Conclusions:The standardized training program for newly recruited nurses in TCM hospitals based on the post competency is scientific and reliable, which has certain reference significance for the training and management of newly recruited nurses in TCM hospitals.