As a major venue of scientific research activities,medical colleges and institutes are also an importance source of providing highly trained medical talents.With the medical education reform deepen,scientific research is now becoming the focus point of exploring the social aspect of medicine.Taking one military medical university as example,this paper demonstrated four specific measures for managing social sciences research in medical colleges.

Objective To discuss the indication and safety of vaginal birth after cesarean .Methods Prospective analysis was clone the 63 cases of successful vaginal delivery from scarred uterus during Jan 2009 to Dec 2012 in this hospital .Results Intensive observation revealed 21 successful cases of vaginal delivery without occurrence of uterus rupture or neonatal suffocation .Postpartum hemorrhage occurred only once .Conclusion Vaginal birth after cesarean is safe as long as its indication is strictly controlled .

N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a good plasma marker for the diagnosis and differential diagnosis of the heart failure.For decompensated heart failure,the double-cut-point strategy including the diagnostic cut-off point and eliminated cut-off point was suggested,and the diagnostic cut-off point can be further divided according to age to further improve the diagnostic accuracy.If the patient's value was in gray interval,doctors should further analyzed the possible confounders,including age,renal function,BMI et al.Recently,more researches were carried out for NT-proBNP in patients with acute coronary syndrome,and some studies showed that its combination with troponin increased the diagnostic efficacy of acute myocardial infarction.The studies of NT-proBNP were still carried out in other areas including atrial fibrillation,cardiomyopathy,valvular disease,pulmonary embolism et al and had obtained the results of the beneficial clinical applications.

This paper presents the situation of secrecy management at colleges and universities,and analyzes the reasons for the inadequacy of capability in this aspect.From the perspective of PAEI management roles,we point out the solutions to improve the capability include strengthening leaderships,targeting,building system,managing risks and raising awareness of secrecy.

According to the strategic planning for disciplinary development of cardiology,the State Key Laboratory of Cardiovascular Disease proposed to recruit overseas high-level talents for innovative ideas and initiatives.Based on previous experience,this paper will introduce the related working experience and conducted a preliminary examination of the retention of oversea talents by analyzing the demographic traits of these high level personnel and measures need to be taken to cater to other needs from them.

Academic activities is the best way to promote academic exchange,which also play an important role in the rapid development of the State Key Laboratory.This paper summed up the innovative management and successful experience of the state key Laboratory of Cardiovascular disease,in order to analyze the functions of organizing academic activities in the laboratory.The paper also indicate that carrying out academic activities would create a good academic atmosphere,which is helpful to the construction of the state key Laboratory.

Objectives To investigate the associations of serum superoxide dismutase ( SOD) , malondialdehyde (MDA), and uric acid (UA) with blood pressure and the prevalence of hypertension in a Chinese population. Methods We measured serum superoxide dismutase (SOD), malondialdehyde (MDA) and uric acid (UA) in 506 randomly selected participants. For database management and statistical analysis, we used the SAS 9.13 Software. Results Compared with normotensive participants, hypertensive patients had significantly lower serum levels of superoxide dismutase activity ( =0.0002), and higher serum levels of malondialdehyde and uric acid ( <0.05) .Univariate analysis indicated that serum superoxide dismutase activity was negatively associated with blood pressure, and serum levels of uric acid (P 0.0001);while serum levels of malondialdehyde was positively associated with blood pressure, and serum levels of uric acid (P 0.05) . There was significant difference in systolic (Ptrend=0.02) and diastolic blood pressure (Ptrend=0.04) between three groups defined by tertiles of serum levels of superoxide dismutase, with a lower blood pressure in the highest tertile than in the lowest tertile. Furthermore, the systolic (Ptrend=0.01) and diastolic blood pressure (Ptrend=0.003) in the highest tertile, which defied by the serum levels of malondialdehyde, were significantly higher than those in the lowest tertile. Conclusions Hypertensive patients have a disturbed oxidative and anti-oxidative balance. Oxidative stress may play a role in the pathogenesis of hypertension in Chinese.

The author briefly introduced the development background,system design,function and implementation effect of the Reservation Management System for the State Key Laboratory of Cardiovascular Disease,investigated the important roles played by informatization construction in the scientific research conducted by the State Key Laboratory.

OBJECTIVE:To find out potential financial risk in the listed Chinese pharmaceutical companies and to provide rec-ommendations. METHODS:The Z-score established with Altman E was adopted to classiy and analyzed empirically 143 listed phar-maceutical companies in China during 1998-2013 by sub-sectors(medical devices,pharmaceutical commercial,biological products chemical raw medicine,traditional TCM). The effects of some data in annual reports on Z-score were validated by using stepwise regression. RESULTS:The result showed that the average Z-score values percentage of the best 3 companies were 90.95%,47.96%and 41.25%,respectively,from 1998-2013;while for the worst 3 companies,the values were 0.80%,1.14%and 1.21%,respective-ly. At the same time,the financial situations of chemical raw medicine companies were the worst among 5 sub-sectors,of which dur-ing 2004-2006,the constituent ratios of companies in“Distress”zones went over 50.00%,which were 60.00%,55.20% and 53.60%,respectively. If counted by calendar year,the market value per share of 10 years and float of 9 years significantly affected the Z-score values(P<0.05);if counted by listed year,the market value per share of 15 years significantly affected the Z-score val-ues. CONCLUSIONS:Although major pharmaceutical companies have good financial status,financial crisis still exists in some companies. Especially,the financial situations of chemical raw medicine companies should not be neglected. The government should pay more attention to share price in order to prevent financial crisis which was induced by stock bubbles;at the same time,supervi-sion system should be established to evaluate the financial situation of listed pharmaceutical companies,even for all listed companies.

BACKGROUND: Special anatomical location makes eye lens expose to stressful situation in a long term. Whether the environmental stress can up-regulate the expression of heat shock proteins in human lens epithelial cells? Whether the synthesis increase occurs in the level of trenscdption or translation, remains unclear.OBJECTIVE: To observe the expression and location of heat shock protein 27 (HSP27) in human lens epithelial cells under the conditions of high temperature and oxidative stress, and to investigate the pathogenesis of the cataract.METHODS: Human lens epithelial cells cultured in vitro were exposed to heat (45 ℃) and oxidative stress (50 mmol/L H_2O_2) for 30 minutes, respectively, then allowed to recover normal conditions. At different intervals (0, 2, 4, 6, 16, 24 hours),immunocytochemistry and reverse transcription polymerase chain reaction were used to determine the expression and localization of HSP27.RESULTS AND CONCLUSION: HSP27 was shown to express in both physiological and stressful conditions. The expressions of HSP27 mRNA and protein ware remarkably increased at 2 hours following heat and oxidative stress, and reached the peak at 6 hours. HSP27 could maintain a high level for 16 hours. The stress-induced HSP27 protein positive particles transferred from the cytoplasm to the nucleus, and gradually shift back to the cytoplasm along time. It is proved that HSP27 exists in lens epithelial cells and can be increased after stress. The data suggested it may play an important protective role in lens epithelial cells in respond to cellular stress.