Objective:To explore the influencing factors of exercise tolerance of acute myocardial infarction (AMI) patients with percutaneous coronary intervention (PCI) .Methods:From August 2016 to July 2019, this study selected 158 AMI patients in the First Affiliated Hospital of Zhengzhou University with PCI by convenience sampling as subjects. All patients completed the cardiopulmonary exercise testing (CPET) after PCI. And then, they were divided into the group of exercise tolerance with constant value (VO 2peak% ≥84%, n=60) and the group of exercise tolerance with value decrease (VO 2peak% <84%, n=98) according to the percentage of peak oxygen consumption (VO 2peak%) . Binary Logistic regression was used to analyze the influencing factors of exercise tolerance. This study observed and recorded the major adverse cardiovascular events (MACE) of patients within 24 months. Results:The influencing factors of exercise tolerance of AMI patients included whether or not being combined with diabetes mellitus ( OR=3.932, P<0.001) and type C lesion ( OR=2.795, P=0.005) with statistical differences. Conclusions:The main independent predictors of exercise limitation among AMI patients with PCI are diabetes mellitus and type C lesion.