Podocalyxin,a sialomucin most closely related to CD34,is expressed by kidney podocytes,hematopoietic progenitors,vascular endóthelia and a subset of neurons.As one of the important apical marker protein,podocalyxin plays an important role in the integrity of the structure and function of nomal podocyte,and is closely related to the prevention of proteinuria.The mechanism of podocyte injury associated with proteinuria remains unkown.The investigation of podocalyxin,a major podocyte protein,is significant in the pathogenesis and process of the primarily glomerulopathies.This paper summarizes the progresses of podocalyxin in podocyte injury of proteinuria associated nephropathy.