Objective To investigate the clinical efficac y of internal fixation with Titanium Alloy(TIA)reconstruction plate in treatment o f clavicular midpiece fracture.Methods 37cases of clavicular midpiece frac-ture underwent open reduction and in ternal fixation with TIA.All the 37c ases were followed up and their clini cal efficacy were analyzed.Results All the clavicle fractures achieved clinical union and satisfactory fun ctional re-covery.Conclusion Open reduction and internal fixatio n with TIA reconstruction plate is on e of the best choices for clavicular midpiece fractures,for it can free the patients from distress of reoperation.[

Objective To extract the molluscicidal active component, Eomecon Chionantha Hance Alkaloids (ECA)from Eomecon Chionantha Hance. Methods The molluscicidal active component from the rootstalk of Eomecon Chionantha Hance was extracted and purified by using the method, 70% alcohol percolation, decompress concentrating, salting-out and so on. Results The final product rate of ECA was 1.009%. Conclusion This method is economic, simple and reliable, and suitable to industrialized production.

AIM: To investigate the relationship between expression of Bmi-1(B cell-specific MLV integration site-1) in gastric cancer and its clinicopathologic significance.METHODS: 146 surgical patients with gastric carcinoma were followed up at least 2 years.Expression of Bmi-1 protein was examined by immunohistochemistry in their archival paraffin embedded tissue specimens.RESULTS: The intensive positive rate of Bmi-1 expression in gastric cancer was 67.8%(99/146).Expression of Bmi-1 was highly correlated with tumor size,clinical stage,lymph node metastasis and T classification(P0.05).The survival rate in the patients with Bmi-1 expression was much lower than that in those patients without Bmi-1 expression(P

Objective To evaluate the initial experience of intracoronary stenting in patients with acute myocardial infarction (AMI) in our hospital.Methods Ballon-expansion stents were deployed in 18 patients (male: 15, female 3, aged between 38-72 years old) with AMI after emergency PTCA. The major indications for intracoronary stenting in our present study include: 1) acute reocclusion or high risk of reocclusion due to intimal dissection; 2) severe residual stenosis (≥50% diameter stenosis) after repeat balloon dilation; and 3) obvious elastic recoil failed to response to repeat intracoronary nitroglycerin infusion. The dilating pressure for stent implantation was 12-18 atm with a dilating time of 10-30 sec. Patients were heparized during catheter maneuvers and were medicated with Ticlopidine (250 mg, twice daily) for 3 months and aspirin (250 mg, once daily) after stenting.Results 1) Coronary angiography (CAG) showed that all patients (n=18) had a single-vessel total occlusion (left anterior decending 9, right coronary artery 8, and left circuflex 1) before emergency PTCA and was successfully restored to TIMI 3 grade blood flow after intracoronary stenting (13 with Nir stent, 1 with Jonson and Jonson stent, and 4 with Cordis stent). 2) Minor residual intracoronary thrombosis was presented in 5 of 18 patients after PTCA, and it was totally disppeared after stenting; 3) One patient with inferior infarction developed Ⅲ degree atrioventricular blockade (AVB) and temporary pacemaker was introduced. This patient died of cardiac tamponade 6 h after stenting due to right ventricular perforation by electrode. No cardiac death, recurrent angina and reinfarction occurred during the 4-16 months follow-up peroid in the other 17 patients; 4) No angiographically restenois was found in all the 3 patients who had a secondary conronary angiography 4 weeks after stenting. 5) Left ventricular ejection fraction (LVEF) determined with Doppler echocardiography 4 weeks after stenting tended to be improved but failed to reach significant difference as compared to the basal LVEF (43.27%±8.43% vs 40.58%±7.23%, P>0.05, n=17) measured within 24 h after the onset of chest pain.Conclusions These results suggest that intracoronary stenting is a highly effective strategy in prevention or treatment of acute reocclusion after emergency PTCA in AMI. Minor residual intracoronary thrombosis after balloon dilation was not a contraindication for stent implantation.

Objective:To investigate the effects of Neibu Huangqi Decoction combined with Kangfuxin Liquid on wound healing after hemorrhoid fistula.Methods:Randomized controlled trial. A total of 90 patients with hemorrhoid fistula surgery in Tangshan Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were selected as the observation objects and divided into 2 groups by random number table method, with 45 cases in each group. The control group was treated with Kangfuxin Liquid after surgery, and the observation group was treated with Neibu Huangqi Decoction. Both groups were treated continuously for 14 days. Wound symptom score was performed before and after treatment. The levels of TNF-α, IL-6 and IL-8 were determined by ELISA. The wound healing time was observed and the wound healing rate was calculated. Adverse reactions were recorded and clinical efficacy was evaluated.Results:The total effective rate was 93.33% (42/45) in the observation group and 66.67% (30/45) in the control group, with statistical significance ( χ2=9.89, P=0.002). After treatment, the scores of pain [(0.63±0.14) vs. (0.97±0.27), t=7.50], exudation [(0.67±0.12) vs. (1.09±0.31), t=8.48], edema [(0.78±0.17) vs.(1.25±0.36), t=7.92], pruritus [(0.78±0.20) vs. (1.32±0.33), t=9.39] were lower than those in the control group ( P<0.01); serum TNF-α [(33.46±2.86) μg/L vs. (45.78±3.92) μg/L, t=25.39], IL-6 [(41.86±5.84) μg/L vs. (56.12±6.75) μg/L, t=15.98], IL-8 [(27.40±3.58) ng/L vs. (36.16±3.84) ng/L, t=16.69] were lower than those in the control group ( P<0.01). The wound healing time of the observation group was shorter than that of the control group ( t=8.60, P<0.01), and the wound healing rate was higher than that of the control group ( t=24.65, P<0.01). During treatment, the incidence of adverse reactions was 11.11% (5/45) in the observation group and 6.67% (3/45) in the control group, without statistical significance ( χ2=0.14, P=0.711). Conclusion:Neibu Huangqi Decoction combined with Kangfuxin Liquid can promote wound healing, reduce inflammatory cytokines, relieve pain and exudation, improve clinical efficacy, and have few adverse reactions.

In the early 1990's, emergency percutaneous transluminal coronary angioplasty (PTCA) has been proven to be the best strategy for acute myocardial infarction (AMI). It has not only resulted in a higher vascular recanalization, but has also further reduced mortality and morbidity, and has greatly improved life quality of patients with AMI.Objective To investigate the effect of emergency PTCA in AMI.Methods Emergency PTCA was performed in 52 AMI patients (male: 43, female: 9) from October 1993 to December 1997 in our hospital. The patients were aged between 31-89 years (±s, 53.7±8.2). Among them, 25 had anterior infarction, 27 inferior infarction. Angiographically infarct-related vessels were left anterior descending artery (LAD) in 27 cases, right coronary artery (RCA) in 22, and left circumflex artery (LCx) in 3. The mean time from the onset of chest pain was 6.12±5.13 h (2-12 h). Primary PTCA (balloon angioplasty without previous thrombolytic therapy) was performed in 34 cases, and rescue PTCA (balloon angioplasty after previous thrombolytic therapy that had failed to restore blood flow) in 15 cases, and immediate PTCA ( balloon angioplasty after previous successful thrombolysis but with severe residual stenosis and reoccurring angina pectoris) in 3 cases. Only the infarct-related vessels was dilated during emergency PTCA which is similarto conventional balloon angioplasty. All patients were given aspirin of 250 mg/d and were heparinized during the first 3-5 days after PTCA. Ticlopidine (250 mg, twice daily) was also given for 3 months if patients had experienced intracoronary stenting.Results Emergency PTCA was successfully performed in 48 of 52 patients (33/34 in primary PTCA, 12/15 in rescue PTCA, and 3/3 in immediate PTCA) which accounts for the initial success rate of 92%. Intracoronary stents were implanted in 18 of the 48 patients due to the presence of different vessel complications. PTCA was failed in 4 patients (3 occurred in rescue PTCA, 1 occurred in primary PTCA). Among the patients, one died of acute pulmonary edema during the rescue PTCA procedure, one had acute reocclusion after rescue PTCA and died of acute pump failure within 24 h. Guiding wire failed to put through lesions in the other 2 patients. Mass intracoronary thrombosis was present in 5 of 34 patients after primary PTCA despite the restoration of TIMI 3 grade blood flow in the distal segment. The residual thrombosis disappeared after urokinase (500 000-1 500 000 IU) was infused into the culprit coronary.Conclusions Clinical studies have suggested that emergency PTCA is more effective in early reperfusion than that of thrombolysis in AMI. Though emergency PTCA is highly effective, but the initial success rate is lower than that of conventional PTCA with a higher complication and mortality. Thus it should be only steadily introduced into AMI.

Pulsatile blood flow plays an important role in maintaining normal vascular endothelial function. Quantitative measurement of pulsatility of human arterial blood pressure and the influence of enhanced external counterpulsation (EECP) on the pulsatility were investigated in this study. Eight healthy young male volunteers aged 22 to 35 were included. A 4F tip transducer catheter was inserted under local anaesthesia into the radial artery up to the aortic arch. Intraarterial blood pressure was recorded before and during EECP. Blood pulse pressure, pulsatility index (ratio of peak pressure to end diastolic pressure) and standard deviation of blood pressure in 5 cardiac cycle was calculated to evaluate the pulsatility of arterial blood pressure. The results showed that blood pulse pressure, pulsatility index and standard deviation of blood pressure were elevated from 47 +/- 5 mmHg, 1.64 +/- 0.11 and 13.6 +/- 1.5 mmHg to 77 +/- 3 mmHg, 2.46 +/- 0.25 and 19.3 +/- 2.2 mmHg before and during EECP respectively (P < 0.05). Decreasing of systolic pressure and increasing of diastolic pressure during counterpulsation were also observed. EECP gives an elevation of pulsatility to human blood pressure.
Adult ; Blood Pressure ; physiology ; Blood Pressure Determination ; Counterpulsation ; Humans ; Male ; Pulsatile Flow

Pulsatile blood flow plays an important role in maintaining normal vascular endothelial function. Quantitative measurement of pulsatility of artery blood pressure and blood flow in dogs and effects of enhanced external counterpulsation (EECP) on the pulsatility were taken in this study. Common carotid artery blood pressure and blood flow were measured in 6 beagle dogs that had suffered from an acute myocardial infarction 6 weeks before. A 6F tip transducer catheter was inserted into the right common carotid artery to measure blood pressure, and blood flow was measured in the left common carotid artery by an electromagnetic blood flow probe under anesthesia before and during EECP. Blood pulse pressure, pulsatility index (ratio of peak pressure to end diastolic pressure) and standard deviation of blood pressure were calculated to evaluate the pulsatility of arterial blood pressure. Blood pulse flow, pulsatility index (ratio of peak flow to trough flow) and standard deviation of blood flow were calculated to evaluate the pulsatility of blood flow. Mean vascular resistance (MVR) was calculated as MVR = mean blood pressure/mean blood flow. Blood pulse pressure, pulsatility index and standard deviation of blood pressure were elevated from 30 +/- 9 mmHg, 1.26 +/- 0.05 and 8.7 +/- 2.5 mmHg to 43 +/- 8 mmHg (P < 0.05), 1.54 +/- 0.13 and 12.4 +/- 2.0 mmHg (P < 0.05) before and during EECP, respectively. Blood pulse flow, pulsatility index and standard deviation of blood flow were elevated from 317 +/- 48 ml/min, 2.85 +/- 0.21 and 96 +/- 21 ml/min to 447 +/- 88 ml/min, 4.56 +/- 0.90 and 131 +/- 39 ml/min before and during EECP (P < 0.05). MVR was decreased from 578 +/- 72 before EECP to 476 +/- 85 Wood units during EECP(P < 0.05). These data demonstrate that EECP gives an elevation of pulsatility to blood pressure and blood flow, thus it may lead to the decrease of vascular resistance.
Animals ; Blood Pressure ; Carotid Arteries ; physiology ; Counterpulsation ; Dogs ; Hemodynamics ; Pulsatile Flow ; Regional Blood Flow ; Vascular Resistance