Objective: To observe the clinical efficacy of treating cervical spondylosis with combined acupuncture and cupping therapies. Method: The patients in the treatment group (30 cases) were treated with combined acupuncture and cupping therapies; and the patients in the control group (30 cases) were treated with acupuncture therapy alone. Then the clinical efficacy was observed after 30 days of treatment. Result: The χ2 test showed that there was significant difference (P＜0.01) between the two groups in recovery rate, total effective rate, relapse rate after six months, and average treatment course. Conclusion: Combined acupuncture and cupping therapies is a better therapy for cervical spondylosis with a shorter treatment course and low relapse rate.

Objective To evaluate the clinical efficacy in the treatment of unilateral micrognath ia by using EAM medical resin and hydroxyapatite (EH) composite material combined with the CAD/ CAM technique.Methods From July 2011 to October 2015,12 cases of unilateral micrognathia caused by different reasons were treated,based on the representative traits and requirements,refering to the unsymmetric counter part by right of CAD/CAM technique.By the 3-dimensional design and reconstruction,we reformed the EH composite material into purposed shape,and insert it in the operative area.Results All the materials were closely suitable to the mandible surfaces.1 case failed because the wound was torn apart;the other 11 patients recovered more than 6 months and were satisfied with the external appearance.Conclusions The EH composite materials combined with CAD/ CAM techniques could be a potential characterized remedy for the unilateral micrognathia.

Objective:To investigate the effects of standardized treatment combined with medical nutrition intervention on blood glucose level, body mass management and glucose metabolism at 3 months postpartum in patients with gestational diabetes mellitus (GDM).Methods:A total of 114 patients with GDM who received treatment in Shunyi District Hospital of Beijing from June 2017 to October 2019 were included in this study. They were randomly divided into observation group ( n = 57) and control group ( n = 57). The control group was treated with standardized therapy, and the observation group was treated with standardized therapy combined with medical nutrition intervention. Blood glucose level, body mass management, glucose metabolism outcomes at 3 months postpartum, pregnancy outcome, and neonatal outcome were compared between the two groups. Results:After treatment, hemoglobin A1c (HbA1c), fasting blood glucose, 2-hour plasma glucose (2hPG) after breakfast, and 2hPG after dinner in the observation group were (5.20 ± 0.34)%, (4.69 ± 0.31) mmol/L, (7.32 ± 2.13) mmol/L, and (7.54 ± 2.36) mmol/L, respectively, which were significantly lower than those in the control group [(6.38 ± 0.42)%, (6.34 ± 0.45) mmol/L, (9.01 ± 2.27) mmol/L, (9.35 ± 2.47) mmol/L, t = 16.48, 22.79, 4.09, 4.00, all P < 0.001]. The increases in body mass and body mass index during pregnancy in the observation groups were (12.19 ± 2.35) kg and (4.52 ± 1.13) kg/m 2, respectively, which were significantly lower than those in the control group [(16.21 ± 2.64) kg, (6.11 ± 1.25) kg/m 2, t = 8.58, 7.12, both P < 0.001]. The abnormal rate of glucose metabolism at 3 months postpartum in the observation group was significantly lower than that in the control group [5.3% (3/57) vs. 8.8% (5/57), χ2 = 0.53, P = 0.462]. The incidences of premature rupture of membranes, polyhydramnios, and cesarean section in the observation group were 5.3% (3/57), 14.0% (8/57) and 15.8% (9/57), which were significantly lower than those in the control group [22.8% (13/57), 35.1% (20/57), 40.4% (23/57), χ2 = 7.27, 6.81, 8.51, all P < 0.05]. There were no significant differences in the incidences of pregnancy-induced hypertension and postpartum hemorrhage between the two groups (both P > 0.05). The incidences of premature births, macrosomia, respiratory distress, neonatal hypoglycemia and hyperbilirubinemia in the observation groups were 5.3% (3/57), 3.5% (2/57), 7.0% (4/57), 3.5% (2/57), 5.3% (3/57), respectively, which were significantly lower than those in the control group [22.8% (13/57), 17.5% (10/57), 21.1% (12/57), 15.8% (9/57), 19.3% (11/57), χ2 = 7.27, 5.96, 5.60, 4.93, 5.21, all P < 0.05). Conclusion:Standardized treatment combined with medical nutrition intervention can effectively reduce blood glucose level in patients with GMD, control body mass, and improve glucose metabolism at 3 months after delivery.

Objective:To evaluate the effectiveness of digital orthognathic surgery in the surgical treatment of patients with hemifacial microsomia (HFM) and patients’ satisfaction.Methods:The clinical data of HFM patients admitted to the Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, Hospital of Stomatology, Wuhan University, from January 2017 to May 2020 were retrospectively analyzed. The digital orthognathic surgery was used to design surgical protocols before surgery. The intermediate wafer and terminal wafer by three-dimensional printing were applied to determine the position of maxillary and mandible bone blocks. The distance change between landmarks in maxillary and chin and the reference planes was measured. The skull CT and face photographs were taken 5 days after surgery to compare the distance between the actual position and the designed position. Data were expressed as the Mean±SD and analyzed by the pairing t-test with P<0.05 considered statistically. The patients’ satisfaction was investigated by interval scale method on day 7 and 6 months after operation. Results:There were 9 HFM patients in this study, included 5 men and 4 women, and the average age was 25.8±3.8 years old. 6 patients were affected on the left side and 3 patients was affected on the right side. All the operations were processed successfully. The wafers were in good position that the maxillary and mandible blocks were moved precisely according to the digital design. There were no accidental fractures of the jaw during the operation. The post-operative photographs and CT showed the stomatognathic system recovered well without serious postoperative complications. The errors between postoperative situation and preoperative designed situation in maxillary and chin were no statistically difference ( P>0.05). The maximum movement error of the maxillary bone block was the mark point of the first molar on the left, with an average error of (0.92 ± 0.34) mm. The patients’ satisfaction scores were averaged 83.2±2.7 points on day 7 after surgery, while the score dropped to 73.8±2.5 points after 6 months. Conclusions:The digital orthognathic surgery technology can satisfy the accuracy requirement of the surgical plan design for HFM patients in correcting the deflect of dental middle line, occlusal plane and chin point. High postoperative satisfaction can be achieved, which may decrease slightly 6 months after operation.

Objective:To evaluate the effectiveness of digital orthognathic surgery in the surgical treatment of patients with hemifacial microsomia (HFM) and patients’ satisfaction.Methods:The clinical data of HFM patients admitted to the Department of Orthognathic & Cleft Lip and Palate Plastic Surgery, Hospital of Stomatology, Wuhan University, from January 2017 to May 2020 were retrospectively analyzed. The digital orthognathic surgery was used to design surgical protocols before surgery. The intermediate wafer and terminal wafer by three-dimensional printing were applied to determine the position of maxillary and mandible bone blocks. The distance change between landmarks in maxillary and chin and the reference planes was measured. The skull CT and face photographs were taken 5 days after surgery to compare the distance between the actual position and the designed position. Data were expressed as the Mean±SD and analyzed by the pairing t-test with P<0.05 considered statistically. The patients’ satisfaction was investigated by interval scale method on day 7 and 6 months after operation. Results:There were 9 HFM patients in this study, included 5 men and 4 women, and the average age was 25.8±3.8 years old. 6 patients were affected on the left side and 3 patients was affected on the right side. All the operations were processed successfully. The wafers were in good position that the maxillary and mandible blocks were moved precisely according to the digital design. There were no accidental fractures of the jaw during the operation. The post-operative photographs and CT showed the stomatognathic system recovered well without serious postoperative complications. The errors between postoperative situation and preoperative designed situation in maxillary and chin were no statistically difference ( P>0.05). The maximum movement error of the maxillary bone block was the mark point of the first molar on the left, with an average error of (0.92 ± 0.34) mm. The patients’ satisfaction scores were averaged 83.2±2.7 points on day 7 after surgery, while the score dropped to 73.8±2.5 points after 6 months. Conclusions:The digital orthognathic surgery technology can satisfy the accuracy requirement of the surgical plan design for HFM patients in correcting the deflect of dental middle line, occlusal plane and chin point. High postoperative satisfaction can be achieved, which may decrease slightly 6 months after operation.

Objective:To investigate the alterations in soft tissue morphology and thickness in the mid-face region of patients with cleft lip and palate (UCLP) secondary to maxillofacial deformity following Le Fort I osteotomy.Methods:A total of 22 patients (16 males and 6 females aged from 17 to 28 years with an average of 20 years) diagnosed with cleft lip and palate secondary to maxillofacial deformity were collected from the Wuhan University Hospital of Stomatology from July 2012 to August 2020. All patients underwent Le Fort I osteotomy. CBCT scans were obtained at T0 (3 days before surgery), T1 (7 days after surgery), and T2 (1 year after surgery). The Dolphin11.95 software and 3D Slicer software were utilized to measure and analyze the soft tissue near the mid-face osteotomy line. Differences in soft tissue thickness before and after surgery were compared.Results:Before and after the operation, the soft tissue thickness at P3, P5, P6, and P8 on the affected side was thicker than that on the healthy side, and the difference was statistically significant, with a P-value of <0.05. At P5, P6, P7, P8, and P9 below the osteotomy line at T2-T0, the degree of postoperative thinning on the affected side was more apparent than that on the healthy side, and there was statistical significance at P6 ( P<0.05). The postoperative soft tissue asymmetry in the Ck region was improved compared with the preoperative one. The preoperative average protruding of the affected side was 0.63 compared with the healthy side, and the postoperative value was 0.17. The preoperative and postoperative Mann-Whitney U tests showed significantly statistical difference. Conclusions:After Le Fort I osteotomy, the facial asymmetry of patients with unilateral cleft lip and palate secondary to maxillofacial deformity is improved. However, there is still a difference in the soft tissue thickness between the healthy side and the affected side, and the change in soft tissue thickness on the affected side is more significant than that on the healthy side.

Primary familial brain calcification (PFBC) is an inherited neurodegenerative disorder mainly characterized by progressive calcium deposition bilaterally in the brain, accompanied by various symptoms, such as dystonia, ataxia, parkinsonism, dementia, depression, headaches, and epilepsy. Currently, the etiology of PFBC is largely unknown, and no specific prevention or treatment is available. During the past 10 years, six causative genes (SLC20A2, PDGFRB, PDGFB, XPR1, MYORG, and JAM2) have been identified in PFBC. In this review, considering mechanistic studies of these genes at the cellular level and in animals, we summarize the pathogenesis and potential preventive and therapeutic strategies for PFBC patients. Our systematic analysis suggests a classification for PFBC genetic etiology based on several characteristics, provides a summary of the known composition of brain calcification, and identifies some potential therapeutic targets for PFBC.
Animals ; Brain Diseases/therapy* ; Xenotropic and Polytropic Retrovirus Receptor ; Brain/pathology*