Objective To find out association mapping of loci related to bipolar disorder on chromosome 4 with microsatellite markers in DNA pooling samples from bipolar disorder cases and normal controls in Shandong province. Methods A total of 22 microsatellite markers on chromosome 4 spaced at approximately 10 cM were selected and two separated DNA pooling samples consisting of 104 bipolar disorder cases and 1000 normal controls were genotyped respectively. Statistic analysis was performed by Chi-square method with CLUMP software to compare the difference in the ratio of each allele in these loci between the two pooling samples. Result Significant statistic differences were found at D4S1592 and D4S402 on chromosome 4 between cases and controls(P＜0.01 ).( D4S1592:x2 = 15.968, P=0.006; D4S402:x2 =31.553, P=0.002). Conclusion The loci of D4S1592 and D4S402 on chromosome 4 are found to be associated with bipolar disorder patients in Shandong province, further screening of the susceptibility genes around these loci is needed.

Stroke is the most common disease of the central nervous system, with high disability and mortality, which seriously affects the quality of life of patients and causes a huge disease burden. However, the overall treatment effect is still unsatisfied at present. Myeloperoxidase (MPO), a kind of peroxidase derived from neutrophils, may play an important role in stroke development through many ways, and has great potential in early diagnosis, clinical treatment and prognosis evaluation of stroke. This article reviews the research progress of MPO in stroke, aiming to provide new ideas for better diagnosis and treatment of stroke in clinic.