One case with fulminant type 1 diabetes during the third trimester of pregnancy was reported.If a patient manifests abrupt onset of hyperglycemia,nausea,vomiting,and bellyache during pregnancy or immediately after delivery,fulminant type 1 diabetes should be considered.

Objective To study the effects of oxytocin antagonists-atosiban on pregnancy outcome after thaw embryo transfer (TET).Methods Between Jul.and Dec.2012,a total of 120 women undergoing TET in Reproductive Medical Center,General Hospital of Tianjin Medical University were randomly allocated into atosiban and control group.They were all transferred 2 or 3 top quality embryos at phase of 7-8 cells.Patients in atosiban group were administered by intravenous administration of atosiban before 30 minutes of embryo transfer with a total administered dose of 37.5 mg.In the control group,no special treatment was given before embryo transfer.All patients in 2 groups underwent progesterone luteal support regularly after embryo transfer,then the clinical rate of pregnancy,implantation and early abortion was compared.Results The clinical pregnancy rate per cycle and implantation rate per transfer were 60％(36/60) and 30.0％ (48/160) in the atosiban group,which were higher than 42％ (25/60) and 20.3％ (31/153) in the control group (all P ＜ 0.05).Early abortion rate was 6％ (2/36)in the atosiban group,which was no statistical difference comapring with control group [16％ (4/25),P ＞ 0.05].Conclusion It was suggested that atosiban treatment before embryo transfer can improve the outcome of pregnancy,and increase clinical pregnancy rate and implantation rate after TET.

Objective To establish an objective method for evaluating the intrinsic characteristics between cold and hot nature of Chinese materia medica(CMM)through the different effects of Mahuang decoction(MHD)and Maxing Shigan decoction(MSD)on animal temperature tropism.Methods The equipment with cold/hot pads was used to investigate the variety ofthe temperature tropism between two groups of mice treated by MHD and MSD,respectively.Meanwhile,the activities ofadenosine triphosphatase(ATPase),superoxide dismutase,succinate dehydrogenase,and malondialdehyde were measured.Results After treated by MHD,the macroscopic behavioral index of remaining rate on warm pad(40 ℃)of mice decreasedsignificantly(P < 0.05),suggesting the enhancement of cold tropism,meanwhile,the internal indices of ATPase activity and oxygen consuming volume increased significantly(P < 0.05),suggesting the enhancement of energy metabolism.On theother hand,the above-mentioned indices in MSD group changed on the inverse way.Conclusion The relative drug natureof MHD and MSD revealed in this study is consistent with the theoretical prognostication or definition.It indicates that theinternal cold and hot nature of CMM could be reflected in ethological way on the changes of animal temperature tropismwhich might be internally regulated by body energy metabolism.

Through our pre-investigation and literature analysis, it was found that rhubarb could be categorized into two types, chrysophanol-type and rhein-type, based on the proportion of the two constituents in the total content of anthraquinones after acid hydrolysis. In this paper, the antimicrobial activities of chrysophanol-type and rhein-type rhubarbs against Staphylococcus aureus were compared with microcalorimetric analysis, in order to illustrate the bioactive differentiability between the two chemotypes. For the aim to display the distinction of chrysophanol and rhein percentage in total anthraquinones, the sampling volume was regulated to make the total anthraquinones equivalent, thus, the antimicrobial difference was only attributed to the difference of chemotypes. The results indicated that the antimicrobial difference between the two chemotypes was confirmable labeled at the biothermokinetic parameters of S. aureus growth affected by the rhubarb samples. The growth rate constant (k1) of the first exponential phase for the growth of S. aureus affected by the rhein-type rhubarb was significantly lower than that of chrysophanol-type (P<0.01), which suggested stronger antimicrobial activity of rhein-type rhubarb than that of chrysophanol-type. However, the antimicrobial activities of rhein-type rhubarbs were not positively correlated to the contents of rhein. It suggested that the antimicrobial activity of rhubarb might be related to some unknown components which were of same accumulating pattern of rhein. The findings in present study provided some experimental evidence on categorizing rhubarb into two chemotypes through the difference of antimicrobial activity on S. aureus by microcalorimetric analysis and, further, offered references to revision of the commercial specification of rhubarb from chemical view.

Objective To observe effect of nursing intervention on post-cardiac arrest syndrome.Methods The study included 35 inpatients with post-cardiac arrest syndrome in our hospital.According to the principle of random draw,the patients were divided into treatment group with 20 cases and control group with 15 cases.The control group received routine nursing while the treatment group received positively corresponding nursing measures.Results The ICU hospitalization days of the treatment group was significantly less than that in the control group (P<0.05).The differences in GCS scores of two groups on the first resuscitation day were not statis-tically significant(P >0.05).On the 7th resuscitation day,the GCS scores of the treatment group was significantly higher than that in the control group(P <0.05).After the treatment,the mor-tality rate after prognosis in the treatment group was significantly better than that in the control group (P <0.05).Conclusion The regular,scientific and rigorous symptomatic nursing is effec-tive in treatment of post-cardiac arrest syndrome,and it is worthy of clinical promotion.

Objective To observe effect of nursing intervention on post-cardiac arrest syndrome.Methods The study included 35 inpatients with post-cardiac arrest syndrome in our hospital.According to the principle of random draw,the patients were divided into treatment group with 20 cases and control group with 15 cases.The control group received routine nursing while the treatment group received positively corresponding nursing measures.Results The ICU hospitalization days of the treatment group was significantly less than that in the control group (P<0.05).The differences in GCS scores of two groups on the first resuscitation day were not statis-tically significant(P >0.05).On the 7th resuscitation day,the GCS scores of the treatment group was significantly higher than that in the control group(P <0.05).After the treatment,the mor-tality rate after prognosis in the treatment group was significantly better than that in the control group (P <0.05).Conclusion The regular,scientific and rigorous symptomatic nursing is effec-tive in treatment of post-cardiac arrest syndrome,and it is worthy of clinical promotion.

This paper was to explore the effect of blood oxygen saturation (SO2) on oxidative damages of erythrocytes under the condition of oxidative stress. Keeping SO2 of cultured erythrocytes in vitro at the states of 0.3, 0.5, 0.7, 0.9 and 0.98, respectively, we induced oxidative stress by tert-buthylhydroperoxide (BHP, 0.15 mmol/L of final concentration). After incubation, antioxidant capacity was assessed by measuring content of reduced glutathin hormone (GSH) in erythrocytes. Methemoglobin (MetHb) content, lipid peroxidation (thiobarbituric acid-reactive substances, TBARS) and denatured globin-chains on the plasma membrane were measured to assess the extent of oxidative damages. The results showed that in the presence of BHP, GSH contents increased from 0.3 to 0.98 groups; MetHb, TBARS and globin-chains levels all dropped with the rise of SO2. In conclusion, antioxidant capacity and oxidative damages of erythrocytes are closely related to SO2, declined SO2 could promote oxidative damages of erythrocytes.
Cells, Cultured ; Erythrocytes ; cytology ; metabolism ; physiology ; Glutathione ; blood ; Humans ; Methemoglobin ; metabolism ; Oxidative Stress ; drug effects ; Oximetry ; methods ; Oxygen ; blood ; Thiobarbituric Acid Reactive Substances ; metabolism ; tert-Butylhydroperoxide ; toxicity

Objective:To investigate fathers′ knowledge, attitude and practice of breastfeeding and to analyze the related factors.Methods:From August 2018 to April 2019, 200 fathers of newborns in a Shanghai tertiary obstetrics and gynaecology hospital were surveyed about their breastfeeding knowledge, attitude and practice by convenient sampling and self-designed questionnaires.Results:The average knowledge score was 9.80±2.61, the attitude score was 38.71±4.45, the behavioral score was 39.72±6.48. Multiple linear regression results showed that parents′ education level and the wives′ delivery times were the main factors affecting breastfeeding knowledge score ( t values were 2.016, 2.068, 2.988, P < 0.05). The fathers′ knowledge score and the wives′ delivery method were the main factors affecting attitude score ( t values were -3.029,5.225, P < 0.05). Attitude score and infants′ age stage were the main factors affecting behavior score ( t values were 1.985, 2.633, P<0.05). Conclusion:Fathers′ breastfeeding attitude was positive, but they still had wrong perceptions. There were many deficiencies in breastfeeding related behaviors of fathers. It is necessary for hospitals, communities or other relevant institutions to educate fathers with knowledge related to breastfeeding, to encourage fathers to pay more attention to breastfeeding and urge fathers′ behavior improvement, so as to increase the rate of breastfeeding and promote the health of mothers and infants.

Objective:To translate the English version of the Self-Regulated Learning Scale in Clinical Nursing Practice (SRLS-CNP) into Chinese, and test the reliability and validity of the Chinese version of the scale.Methods:The Brislin translation model was adopted to translate the scale forward and back to form the Chinese version of SRLS-CNP. The Chinese version of SRLS-CNP was culturally adjusted through cognitive interviews, expert consultations and pre-surveys. From December 2020 to April 2021, convenience sampling was used to select 1 452 nursing undergraduates from 4 undergraduate medical schools in Anhui Province as the research object. The Chinese version of SRLS-CNP was used for investigation to test the reliability and validity of the scale.Results:The Chinese version of SRLS-CNP included 2 subscales of motivation and learning strategies, with a total of 16 items. The motivation subscale extracted 2 common factors, and the cumulative variance contribution rate was 74.709%. The learning strategy subscale extracted 3 common factors, and the cumulative variance contribution rate was 76.364%. The Cronbach's α coefficient of the total scale was 0.940. The Cronbach's α coefficient of the motivation subscale was 0.875, and the Cronbach's α coefficient of each dimension was from 0.850 to 0.867. The Cronbach's α coefficient of the learning strategies subscale was 0.919, and the Cronbach's α coefficient of each dimension was from 0.807 to 0.886. The half-reliability coefficient of the total scale was 0.882, and the half-reliability coefficients of the motivation and learning strategies subscale were 0.698 and 0.871, respectively. The test-retest reliability coefficient of the total scale was 0.936, and the test-retest reliability coefficients of the motivation and learning strategies subscale were 0.857 and 0.832, respectively.Conclusions:The Chinese version of SRLS-CNP has good reliability and validity, and can be used to evaluate the self-regulated learning ability of clinical nursing practice of undergraduate nursing students in China.

Objective To investigate the prevalence of thyroid nodules and thyroid dysfunction in southern mountainouss areas of Ningxia.Methods A cross-sectional study was conducted among a representative sample of 10 639 adults in Jingyuan county with a population proportionate sampling method.High-resolution ultrasound was used to examine the thyroid and fasting blood specimens were collected in the morning for measurement of TSH,FT4,FT3.Chi-square test and spearman rank correlation analysis were used for statistical analysis.Results The prevalence of thyroid nodules was 29.08％,the sex-and age-adjusted rate was 27.17％.The prevalence of thyroid nodules was higher in women than in men (32.68％ vs.24.88％,x2=76.029 2,P＜0.001) and age was positively associated with thyroid nodules (r=0.272,P＜0.001).The rate of thyroid dysfunetion,subclinical hypothyroidism,subclinical hyperthyroidism,hypothyroidism,hyperthyroidism were 17.39％,13.00％,0.42％,0.96％,3.01％,respectively.The prevalence of thyroid nodules was higher in abnormal TSH group than in normal TSH group (39.44％ vs.27.24％,x2=95.624 0,P＜0.001).The level of THS,FT3,FT4 in thyroid nodules group differed fromn control group (Z=-9.144,P＜0.001;Z=-6.140,P＜0.001;Z=-1.997,P=0.046).Conclusion The prevalence of thyroid nodules and thyroid dysfunction were higher in southern mountainous areas of Ningxia.The relationship between thyroid nodules and thyroid function needs further research.We should pay attention to the early screening and diagnosis of thyroid nodules in mountainous areas.