Objective To study the therapeutic effect of Tongfu Xingshen Oral Liquid on the cerebral infarction of phlegm-heat accumulated in large intestime and wind-phlegm invading upward type and the impact of this Oral liquid on plasma ET-1,TNF-α and the blood viscosity.Methods 60 cases of cerebral infarction patients were randomly divided into Tongfu Xingshen Oral Liquid treatment group(n=30)and conventional therapeutic group(n=30).Besides Routine treatment was used in the two groups,the Tongfu Xingshen Oral Liquid,100ml twice dally,was added in the treatment group.The course of treatment for both groups was 20 days.RIA,double-antibody sandwich enzyme-linked immunosorbent assay (ELISA)and LG-R-80A hemorbeology instrument were used to determine the level of all patients'plasma ET-1,serum TNF-α,blood viscosity,before and after the treatment.Meanwhile,neurological impairment scale Was assayed before and 28 days after the treatment.30 healthy people were recruited as controls.Results The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value.RBC hardness plot,fibrinogen(FI)levels in cerebral infarction patients were significantly higher than healthy people.The plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)level were positively correlated with the acute cerebral infarction.Thetotal efficiency of the treatment group(90%)was significantly higher than that of the conventional group(72.5%,P＜0.05).The plasma ET-1,serum TNF-α,whole blood viscosity value,Plasma viscosity value,RBC hardness plot,fibrinogen(FD levels were decreased after treatment in the both groups,while the reductions in the treatment group were more obvious than in the conventional therapy group(P＜0.05).Conclusion Tongru Xinshen Oral Liquid can improve the prognosis of cerebral infarction by degrading plasma ET-1,serum TNF-α,whole blood viscosity value,plasma viscosity value,RBC hardness plot,fibrinogen(FI)of acute cerebral infarction patients and degrading cerebrovascular endothelial cells damage,improvingthe clinical symptoms and rehabilitating of neurological defects,.

Objective To explore humor experience and its relationship with theory of mind in patients with schizophrenia. Methods sixty?one schizophrenic patients without treatment and sixty?three healthy subjects were assessed with the Humor Picture Test ( HPT) ,Humor Video Test ( HVT) and the Theory?of?Mind Picture?Se?quencing Task ( ToM?PST) . Results Compared with healthy subject in HPT,schizophrenic patients showed sig?nificantly higher non?humor picture rating score (24.41 ± 8.82 vs 28.41 ± 11.56, P<0.05),and less humor picture rating score (45.65 ± 11.49 vs 34.41 ± 13.06, P<0.05). Compared with healthy subject in HVT,schizophrenic patients also showed significantly less humor video rating score (3.56 ± 0.57 vs 2.46 ± 0.79, P<0.01) and the number of standard humorous moments (3.68 ± 1.19 vs 2.42 ± 1.40, P<0.01) and the sensitivity of standard hu?morous moments?d’(humor) score (1.11 ± 0.46 vs 0.47 ± 0.42, P<0.01). Schizophrenic patients had significant?ly less total score (39.89 ± 12.33 vs 58.76 ± 0.64, P<0.01) of ToM?PST compared to normal control. Correlation analysis showed a negative correlation between d’ ( humor) score and the Positive and Negative Syndrome Scale ( PANSS) total score ( r=-0.380, P<0.01) for the patients. There was significantly negative correlation between non?humor picture rating score and ToM?PST total score ( r=-0.316, P<0.05) ,and positive correlation between d’ (humor) score and ToM?PST total score ( r=0.400, P<0.01) in schizophrenic patient. After controlling for the PANSS total score,the correlation between d’(humor) score and ToM?PST total score remained significant. Conclusion Schizophrenic patients have poor humor experience,which is related to the impairments of theory of mind.Humor experience deficit may share a common neuropsychological base with the impairment of theory of mind.