1.Analysis of the Utilization of Antibiotics in TypeⅠIncision Surgery of Our Hospital before and after Special Rectification
Dan LYU ; Ling LI ; Danping DU ; Huijun QU ; Xueqian HU ; Hongjuan XIE
China Pharmacy 2015;26(35):4902-4904
OBJECTIVE:To evaluate the effect of clinical antibiotics use special rectification in our hospital. METHODS:100 discharged medical records of typeⅠincision surgery were randomly sampled from our hospital during May in 2010 to Apr. in 2011,May in 2011 to Apr. in 2012,May in 2012 to Apr. in 2013,May in 2013 to Apr. in 2014,totaling 400 records. And then evaluation indicators were analyzed statistically,such as antibiotics use intensity,perioperative DDDs of antibiotics in typeⅠinci-sion surgery,DUI,types of antibiotics during perioperative period,medication time,etc. RESULTS:Since the implementation of clinical antibiotics use special rectification in May 2011,the utilization ratio of antibiotics in typeⅠincision surgery of our hospital decreased from 96% to 33%;DUI decreased from 1.44 to 0.79;while reasonable rate of drug selection increased from 19.8% to 100%,and that of medication time increased from 43.8% to 100%. CONCLUSIONS:Rational medication evaluation indicators in typeⅠincision surgery of our hospital have been improved after the implementation of clinical antibiotics use special rectification.
2.Improving the Efficiency of Emergency and Critical Care Platform Based on OKR Mode
Lanfang DU ; Mingxue LI ; Yipei WANG ; Li MA ; Xueqian MA ; Hongxia GE ; Shuo LI ; Qingbian MA
Chinese Hospital Management 2023;43(12):49-51
The shortage of emergency and critical care resources has become increasingly prominent,seriously reducing the quality and safety of care.How to improve the efficiency of the emergency and critical care platform is an urgent problem to be solved.Since 2020,the emergency department of Peking University Third Hospital has achieved an increase of 10%-20%in the annual visits of emergency and critically ill patients,the reduction of the emergency department length of stay and the improvement of survival rate using Objectives and Key Results(OKR)as an advanced management tool.It provides a new paradigm for improving efficiency of emergency department in large general hospitals.
3. Expression of GTF2IP23 in breast cancer and it mediated regulation of GTF2I
Shuwei ZHOU ; Beibei SU ; Yueqing FENG ; Xueqian DU ; Hui ZHAO
Chinese Journal of Oncology 2019;41(12):918-922
Objective:
To investigate the expression level of antisense transcript of pseudogene, general transcription factor Ⅱi psedugen23 (GTF2IP23), in breast cancer and its effect on the host gene general transcription factor Ⅱi (GTF2I).
Methods:
The expressions of GTF2IP23 and GTF2I were detected in 40 cases of invasive breast cancer tumors and their counterparts by using quantitative real-time polymerase chain reaction (qRT-PCR). The effects of GTF2IP23 on the expression of GTF2I gene and cell proliferation and migration were analyzed by overexpression of GTF2IP23 in breast cancer cells.
Results:
The expression of GTF2IP23 mRNA in breast cancer tissues was significantly higher than that in adjacent tissues (