Objective:To investigate the effect of nano silver dressing as adjuvant therapy on wound healing, vascular endothelial growth factor (VEGF), and epidermal growth factor (EGF) levels in patients with deep and extensive burns.Methods:A total of 100 patients with deep and extensive burns admitted to the Zhangjiakou First Hospital from May 2022 to May 2023 were retrospectively selected and divided into a control group and an observation group according to different treatment methods, with 50 patients in each group. The control group was treated with recombinant human epidermal growth factor, while the observation group was treated with nano silver dressing in addition to the control group. A comparative analysis was conducted on the levels of serum EGF, VEGF, tumor necrosis factor alpha (TNF-α), interleukin-10 (IL-10), and intercellular adhesion molecule-1 (ICAM-1) between two groups, as well as their recovery status, pain rating scale (NRS) score, wound healing rate, scar color, thickness, vascular distribution, and softness score.Results:Before treatment, there was no statistically significant difference in the levels of VEGF, EGF, TNF-α, IL-10, and ICAM-1 between the two groups (all P>0.05); After treatment, the levels of VEGF, EGF, IL-10, and ICAM-1 increased in both groups, while the level of TNF-α decreased. The observation group had higher levels of VEGF, EGF, IL-10, and ICAM-1 than the control group, and lower levels of TNF-α than the control group, with statistically significant differences (all P<0.001). Compared with the control group, the observation group had a shorter disappearance time of burn secretions, wound healing time, and inflammation symptoms (all P<0.001). After dressing change, the NRS score level of the observation group was lower than that of the control group ( P<0.001). The wound healing rate in the observation group was higher than that in the control group at 1, 3, and 6 months (all P<0.001). After 6 months of treatment, the color, thickness, vascular distribution, and softness scores of both groups were lower than before treatment, and the observation group was lower than the control group (all P<0.001). Conclusions:The use of nano silver dressings as adjuvant therapy for patients with deep and extensive burns can shorten wound healing time, improve EGF, VEGF, and ICAM-1 levels, alleviate inflammatory reactions, and improve the condition.