Objective To study the effect of the combined psychological intervention of ambroxol on the patients with lung cancer after thoracoscopic lobectomy. Methods January 2015 to December 2016, Beijing Jian Gong Hospital under thoracoscope lung resection of 64 cases of patients with lung cancer, the control group treated with saline 600 mL/d, experimental group implementation of ammonia bromine line on postoperative 3 days for the patient on the day of surgery until given intravenous 600 mL/d hydrochloric acid ammonia bromine injection combined psychological intervention treatment. Results There were no deaths in the perioperative period, but the lung complications in the experimental group were significantly lower than those in the control group. There were significant differences in mechanical ventilation, ICU time, postoperative hospital stay, and treatment cost after surgery (P < 0.05). Conclusion For patients with lung cancer in perioperative implementation under the thoracoscope lung resection and intravenous hydrochloric acid ammonia bromine joint line comments fluid psychological intervention treatment, effectively improve the patients' lung function and significantly lower the incidence of complications, shorten the patient's hospital stay, reduce the economic burden, and can be applied clinically.

Objective To observe application of optimized nursing in myocardial infarction patients with percutaneous coronary intervention(PCI).Methods The data of 80 acute myocardial infarction patients with PCI in our hospital were retrospectively analyzed.The patients were divided into observation group and control group according to time of admission.And 47 patients in observation group were treated with high quality nursing care, and 33 in the control group with regular health care.Vascular hemodynamics index, postoperative complications, hospitalization days, Barthel index, SAS and SDS scores were observed.The clinical effect of different healthcare modes was evaluated.Results Compared with the control group, the LVEDD of the observation group was (52.8±1.7) mm, which was lower than (54.2±1.6) mm in the control group, EF in observation group was (54.0±1.8)%, which was significantly higher than (48.3±1.4)% in control group and the differences were statistically significant (P<0.05).The incidence rate of adverse reactions in the observation group was 12.76%, which was significantly lower than 30.30% in the control group.At the same time, the hospitalization time of the observation group was significantly shorter than that of the control group.After treatment, the Barthel indicators of the observation group was higher than that of the control group, and the SAS and SDS scores in the observation group were lower than that in the control group (P<0.05).Conclusion For PCI patients with myocardial infarction during perioperative period, strengthening nursing care can effectively improve the treatment efficiency, promote physical and psychological rehabilitation.

Objective To observe application of optimized nursing in myocardial infarction patients with percutaneous coronary intervention(PCI).Methods The data of 80 acute myocardial infarction patients with PCI in our hospital were retrospectively analyzed.The patients were divided into observation group and control group according to time of admission.And 47 patients in observation group were treated with high quality nursing care, and 33 in the control group with regular health care.Vascular hemodynamics index, postoperative complications, hospitalization days, Barthel index, SAS and SDS scores were observed.The clinical effect of different healthcare modes was evaluated.Results Compared with the control group, the LVEDD of the observation group was (52.8±1.7) mm, which was lower than (54.2±1.6) mm in the control group, EF in observation group was (54.0±1.8)%, which was significantly higher than (48.3±1.4)% in control group and the differences were statistically significant (P<0.05).The incidence rate of adverse reactions in the observation group was 12.76%, which was significantly lower than 30.30% in the control group.At the same time, the hospitalization time of the observation group was significantly shorter than that of the control group.After treatment, the Barthel indicators of the observation group was higher than that of the control group, and the SAS and SDS scores in the observation group were lower than that in the control group (P<0.05).Conclusion For PCI patients with myocardial infarction during perioperative period, strengthening nursing care can effectively improve the treatment efficiency, promote physical and psychological rehabilitation.

Objective To investigate the effects of p38 MAPK inhibitor on glutamate (Glu), glutamine (Gln), taurine amino acid (Tau), glycine (Gly) and gamma aminobutyric acid (GABA) in hippocampus of rats with vascular dementia (VD).Methods Twenty-four healthy male SD rats were randomly divided into sham operation group, VD model group and inhibitor group. VD model was established by permanent ligation of bilateral carotid artery method, and the sham operation group stripping bilateral carotid artery but not ligation. Rats of the inhibitor group were injected p38 MAPK inhibitor SB202190 after the establishment of VD model. Morris water maze was used to evaluate the learning and memory function of rats. The samples of DG region of hippocampus were collected by microdialysis, and the contents of amino acids were detected. Results The learning and memory abilities were significantly better in sham operation group and p38 MAPK inhibitor group than those of VD model group. The latency time was significantly shorter in p38 MAPK group than that of VD model group. The time of locating the platform quadrant and the number of crossing the original platform were significantly higher in sham operation group and p38 MAPK inhibitor group than those of VD model group (P <0.05). Compared with sham group, the levels of Glu, Gln and Tau were significantly lower, and Gly and GABA were significantly higher, in VD group and p38 MAPK inhibitor group (P<0.05). Compared with VD group, Glu, Gln and Tau were significantly increased, Gly and GABA were significantly decreased in p38 MAPK inhibitor group (P<0.05). Conclusion p38 MAPK inhibitor has protective effect on VD hippocampal injury, which may be related to its ability to inhibit VD-induced abnormal secretion of amino acids and regulate the secretion of various amino acids.

Objective To observe local expressions of hypoxia-inducible factor-1α (HIF-1α) and vascular endothelial growth factor (VEGF) in Fischer 344 rats with glioma in the sub-acute phase after photodynamic therapy (PDT).Methods Thirty-two fischer 344 rats were implanted 9L cells into brain and randomly subjected to no treatment and PDT treatment (40 J/cm2,80 J/cm2,120 J/cm2).All animals received PDT treatment mediated with 5-Aminolevulinic acid (ALA) on the seventh day after implantation,respectively,and were then sacrificed at 7 days after PDT treatment.The tumor volume was measured by H&E staining,and the expressions of VEGF and HIF-1α in either glioma tissue or Brain adjacent to tumor(BAT) were detected by Western blot.Results The tumor volumes of control and 40,80,and 120 J/cm2 groups were (103.27 ± 8.83),(73.93 ± 7.55),(57.89 ± 7.53),and (48.57 ± 6.86) mm3,respectively.Tumor volumes decreased significantly after ALA-PDT treatment(F =216.183,P =0.000),and the decrease in tumor volume was PDT optical dose dependent(P ＜ 0.001).Both VEGF and HIF-1 α expressions in glioma tissue were very high and no significant difference was found (VEGF:F =1.867,P =0.155 ; HIF-1 α:F =2.106,P =0.119) in all groups in the sub-acute phase after PDT,which were detected by Western blot.However,there were little VEGF and HIF-1α expressions in BAT and the expressions gradually increased with the increased dose of PDT(VEGF:F =37.065,P =0.000 ; HIF-1 α:F =39.775,P =0.000),among which PDT with 120 J/cm2 had the most obvious effect.Conclusion ALA-PDT effectively reduces glioma;however,it induces local expressions of HIF-1α and VEGF in BAT.

OBJECTIVE:To study the safety and efficacy of Neuroform self-expanding stent for symptomatic intracranial artery stenosis.METHODS:A total of 37 patients with symptomatic intracranial artery stenosis received treatment at the Department of Neurosurgery,Affiliated Hospital of Behua University and Xuanwu Hospital were selected,who were ineffective to anticoagulation and antiplatelet treatment,including 24 males and 13 females,aged from 49 to 72 years,mean aged 64 years.All patients were received Neuroform self-expanding stent following angiography.RESULTS:All patients underwent PTAS with mean preoperative stenosis were reduced from 64% to 24% after percutaneous transluminal angioplasty (PTAS).The technically successful rate was 100%.All the patients were received a 6-22 month follow-up (average 13 months).The average artery stents was retrieved by 50%-90% after stent deployment.There was no arterial dissection,acute occlusion of the target artery or symptomatic distal emboli.Within the follow-up period,1 patient endured asymptomatical artery full occlusion.Two stents were implanted simultaneously in 3 patients,1 of them suffered bilateral vertebral artery stenosis,and 2 had right vertebral arterial and basilar artery stenosis.One patient suffered acute in-stent thrombosis and recovered after thrombolytic therapy.No pathogenetic condition was aggravated in the follow-up.CONCLUSION:The application of Neuroform self-expanding stent can alleviate the ischemic symptoms of patients with vertebrobasilar stenosis and elevate the operative safety and effectiveness.However,further study is needed to evaluate the long-term therapeutic effect.

Objective To explore the application effect of modified disinfection posture in coronary artery bypass grafting(CABG).Methods A total of 50 patients who would undergo CABG were recruited in this study by purposive sampling method in Xuzhou Central Hospital from January 2014 to December 2015. They were divided into the control group(25 cases,conventional disinfection posture)and the observation group (25 cases,modified disinfection posture)according to the random number table. The central venous pressure (CVP),blood pressure(BP)and heart rate(HR)were monitored between two groups before and after placing disinfection position with leg-raising immediately and after restoring horizontal position immediately. The comfort of body,the convenience of operation,the time of placing position and disinfection were investigated or recorded during the process of disinfection.Results There was no statistically significant difference in the time of placing position and disinfection during surgery between two groups(P>0.05). There was also no statistically significant difference in the comfort and satisfaction degree of doctors during surgery between two groups(P>0.05). The hemodynamic variables had no significant difference in two groups before leg-raising immediately(P>0.05). After leg-raising immediately,the systolic pressure,diastolic pressure,CVP and HR in the control group [(121.313±4.116), (70.423±3.291),(8.524±0.283) mmHg,(84.193±3.682) times/min] were higher than those in the observation group [(116.323±6.242),(66.191±11.468),(7.254±0.989) mmHg,(67.524±3.193) times/min] with significant differences(t=2.013,2.316,5.913,16.205;P<0.05). After restoring horizontal position immediately,the systolic pressure,diastolic pressure,CVP and HR in the control group [(109.267±6.167),(60.766±5.233),(4.063±0.572) mmHg, (86.524±4.254) times/min] were higher than those in the observation group [(101.274±9.156),(65.352±3.254), (3.544±0.623) mmHg,(69.933±7.424) times/min] with significant differences(t=3.450,2.025,2.705,9.266;P<0.05).Conclusions The application of modified disinfection posture in patients with general anesthesia and CABG has no effect on the comfort of body,the convenience of the operation,and it will not increase the time of placing position and disinfection. The modified disinfection posture can effectively avoid the impact of conventional disinfection posture on the hemodynamic variables and can improve the quality of nursing care.

Objective To investigate implementation of surgical site marking in a certain general hospital in Xuzhou, and to explore factors affecting accuracy of surgical site marking. Methods 110 medical workers were surveyed by self-made “Questionnaire of awareness of surgical site marking of medical workers”and “Evaluation form of implementation of surgical site marking”. Evaluation was also conducted to 1 762 surgical patients with 2 428 cases of marking. Results Among the 2 428 surgical sites, marking rate was 70. 55%, with rate of accurate marking 81. 10% and a total score of ( 14. 64 ± 1. 50) points; 677 cases were without markings, accounting for 27.88%;188 cases (7.42%) were with errors of integrity, 75 cases (3.09%) with errors of effectiveness, 32 cases (1.32%) with errors of accuracy, and 36 cases (1.48%) with errors of implementation;84. 54% of the medical workers believed surgical markings were helpful to surgery safety, 51. 82% found surgical makings could not meet the needs of clinical surgery, and 88.18% thought it necessary to improve surgical marking system; evaluations by medical workers of different ages, working years and professional titles were statistically significant (t/F=3.260, 16.348, 2.951; P<0.05). Conclusions Due to lack of a unified standard marking system, low implementation rate and effectiveness of the standard, implementation of surgical site marking still needs to be improved.