Objective To study characteristics of clinical manifestations of patients with neuropsythiatric systemic lupus erythematosus(NPSEL). Methods From Jan.2000 to Oct.2004,the symptoms、signs and results of assistant check of 36 patients with NPSEL were analysed and summarized. Results 9 kinds of symptoms are complained,in which headache、weakness and disorder of consciousness were most frequent;13 kinds of signs were found,in which pathologic reflex、disorder of consciousness and limb paralysis were most frequent. Conclusion (1)NPSEL is a kind of manifestation of active SEL.(2)No matter how long disease course of SEL may be,the patients can be involved by NPSEL.(3)Manifestations of NPSEL is complicated.

In view of the particularity of medical experiments,it's essential to improve the quality of medical university project and prevent academic misconduct for the authenticity and standardization of the experimental records.The paper discusses some solutions to these problems in standardization and management criterion of medical experimental records,and recommends the evaluation criterion of Capital Medical University for medical experimental records.

Objective To discuss the clinical characteristics of gastric stromal tumor (GST),as well as their diagnosis and treatment.Methods The clinical and pathological data of 18 patients with GST were retrospectively analyzed.Results The chief clinical manifestations included abdominal pain or discomfort,gastrointestinal bleeding and the abdominal mass.Only a rectum stromal tumor in 1 case diagnosed before operation.All the 18 patients were treated surgically,of all 17 cases were resected completely,1 case was rssected palliatively. The microscopic pathological morphology were exclusively fusiform cells,immunohistochemical analysis display positive reactivity for CD117 ( 16/18 ),CD34 ( 11/18 ),positive reactivity for CD117 and CD34 (15/18).Conclusion The confirmed diagnosis rate of preoperative-GIST is low and digestive tract symptoms have no specific.The diagnosis of GST mainly depends on pathologicl analysis.The size of the tumor is the important marker to the diagnosis of benign of malignant GST.At present,the operation is still the main method to treat GST.Appropriate treatment with Glivec can improve the prognoeis of patients with GST.

Forty cases of bronchial asthma were treated by comprehensive methods of acupuncture, ear-embedding and acupoint-injecting. Thirty-six cases were treated by single body acupuncture and 38 cases were treated by herbal medicine for comparison. The therapeutic effects were analyzed among the three groups. The total effective rate was 95.0% in the comprehensive group, 80.6% in the single acupuncture group and 73.7% in the herbal medicine group, with a significant difference (P＜0.05) among the three groups. The combined use of acupuncture, ear-embedding method and acupoint-injecting method were better than single acupuncture and herbal medicine in the treatment of asthma.

As the capital WaS invested increasingly to key disciplines,the university regarded the performance.Strengthening the evaluation on performance will help to the development of the disciplines.The omni directional performance evaluation iS a mode of all orientation.which will help the performance evaluation of disciplines go on well.At the same time.it should be paid attention to the design of the evaluation index,and the selection of the persons ioining in the evaluation team and the time of the evaluation.

Objective To explore the expression and clinical significance of constitutive androstane receptor(CAR)in placenta syntrophoblast from patients with intrahepatic cholestasis of pregnancy(ICP).Methods Placenta were collected from women with ICP who delivered from April 2009 to March 2010 in First Affiliated Hospital of Chongqing Medical University.According to the severity of ICP,patients were classified into mild ICP group(n=10)and severe ICP group(n=10).Ten healthy pregnant women who delivered in the same period were chosen as control group.The location of CAR protein in placenta was studied by immunohistochemical streptavidin-biotin complex(SABC)method.CAR mRNA level was determined by reverse transcription(RT)-PCR technique and CAR protein expression level was determined by western blot.Results(1)CAR was located in the placenta syncytiotrophoblastic cells in control group and mild ICP group,showed light tan when stained,and was mainly in the cytoplasm.In severe ICP group,CAR was also located in placenta syncytiotrophoblastic cells but mainly in the nucleolus,showed dark tan when stained.(2)The mRNA expressions of CAR in control group,mild ICP group,severe ICP group were 0.06 ±0.03,0.07 ±0.03 and 0.56±0.03.respectively.CAR in severe ICP group was significantly higher than those in control group and mild ICP group(P＜0.05).The difference of mRNA between control group and mild ICP group wag not statistically significant(P＞0.05).(3)The CAR protein levels in control group,mild ICP group,severe ICP group were 0.74±0.03,0.79±01 03 and 1.02±0.04,respectively.CAR protein expression in the severe ICP group was significantly higher than the other two groups(P＜0.05).And there was no statistical significance between mild group and control group(P＞0.05).Conclusion In ICP women.especially severe ICP patients,the CAR expression in placenta syncytiotrophoblastic cells increased appreciably,which may be involved in the maintenance of placenta barrier function and protection in ICP pathogenesis.

Disease bio-banks are an important strategic resource for medicine development. Such a bank with complete information and high information sharing enhances the competitiveness of medicine and promote the development of translational medicine. The present development of such banks is found with such setbacks as weak government leadership and standardization, as well as lack of a sharing mechanism. Therefore medical institutions should strengthen their standardization and informationization of disease bio-banks, which deserve sufficient government policy support and guidance. These efforts will help preserve our rich clinical resources, in addition to their integration and sharing for medicine advancement.

ObjectiveTo explore the best treatment method of cerebral artery dissection.Methods This study included eight patients who were definitely diagnosed as cerebral artery dissection by the cerebral angiography in our department of neurology during Oct.2009 and Nov.2011.They were all treated by the anticoagulation or anti-platelet methods.Some patients received the stent therapy.All patients' were followed for at least three months. The treatment effect was assessed by NIHSS,mRS and by the cerebral angiography.ResultsSix patients had carotid artery dissection,2 had vertebral artery dissection.Four patients were given anticoagulant therapy and the other 4 were given anti-platelet therapy. The reexamination by angiography 10-14 days after admission showed that in 3 patients,the stenosis was aggravated or the infarction occurred.They were diagnosed as having repeated transient ischemic attack (TIA) during pharmacotherapy and received stents for treatment.There was no TIA and cerebral infarction in the follow-up period after individualized therapy.Mean NIHSS scores of 8 patients between pre and post treatment were 5.9,1.6 respectively. Mean mRS scores pre and post treatment were 2.5,0.9respectively.Conclusion The treatment for patients with cerebral artery dissection should be individuated.The patients in acute stage should get anticoagulation,anti-platelet therapy and angiography re-examination.According to the clinical manifestation and cerebral angiography,the next step for the treatment should be done.

Objective This article takes the capital special research program of Chinese medicine as an example to explore the role of special funds in supporting the development of non-dominant subjects and balancing the development of various disciplines.Methods Statistical data analysis was conducted to analyze the approved projects,papers published and patents of Capital Medical University's Chinese medicine and Chinese medicine disciplines during the period of special establishment.Results With the support of special funds,the number of approved projects and output of achievements has been significantly improved.Conclusions The positive role of the special fund on the training of talents,the development of the subject and the basic clinical cooperation is confirmed.Through the analysis of the problems and countermeasures in the management process,it provides a reference for the development of other non-dominant subjects.

Objective To establish a set of sound and scientific managing procedures and systems that conforms with the current needs and reform of the scientific research management methods .Methods Based on the current operation status of the scientific research management system in colleges of domestic universities ,this paper expounds and analyzes the theory and method of holistic quality management from the perspective of ISO9000 quality management system .Results Bring in the ho-listic quality management idea into the fields of college management ,especially cater to the science and technology management in college .Conclusions Provided a reference for bring in and comprehensive construction of ISO 9000 quality management sys-tem in scientific research management in colleges at universities .