1.Improvement of the Quality Standard of Toxic Traditional Chinese Medicines
China Pharmacy 2001;0(12):-
OBJECTIVE:Suggest to improve the quality standard of toxic traditional Chinese medicines.METHODS:The"content determination"and"limit test"of 72 toxic traditional Chinese medicines recorded in Chinese pharmacopoeia(2005 edition) were briefly introduced.RESULTS:Only 11%of the total 72 toxic traditional Chinese medicines had the items of both"content determination"and"limit test".CONCLUSION:The quality standard of toxic traditional Chinese medicines should be improved to achieve quality control in accordance with the standard of"low toxicity but high effectiveness"so as to ensure safe and effective drug use in the clinic.
2.Exploration on the Effect of Micro-powder Technique on the Application of Traditional Chinese Medicine
China Pharmacy 2001;0(11):-
OBJECTIVE:To explore the effect of micro-powder technique on the application of traditional Chinese medicine. METHODS:The physical property of the micro-powder and its effect on curative effect, toxicity and pharmaceutical engineering were analyzed. The efficacy of traditional Chinese medicine micro-powder was compared with traditional pieces and decoction. RESULTS:As compared with traditional pieces and decoction, traditional Chinese medicine micro-powder represented many advantages but there were a series of problems such as the change of curative effect and the toxicity in the process of application. CONCLUSION:The micro-powder technology is beneficial exploration to the traditional Chinese medicine dosage-form reform, which should be paid attention and studied.
3.TREATMENT TREND FOR WEGENER'S GRANULOMATOSIS——ANALYSIS OF 12 CASES
Chinese Journal of Radiation Oncology 1992;0(04):-
12 patients with histologically proved wegener's granulomatsis were treated from May 1974 to March 1983.The 3-、 5- and 10- year survival rate S were 83%、64%、50% , respectively. The survival rate was higher in the female. Limited lesions gave a better survival rate than generalized ones.Patients with limited lesions should be treated mainly by radiotherapy alone. The optimal dose was 4000-5500 cGy/4-5.5wk.Patients with generalized lesions should be treated by radiotherapy combined with chemotherapy (CTX 4-8g or CCNU 100mg P.O.), hormone (cortisone 30mg/day),and antibiotics.
4.Determination of Gallic Acid and Caffeine in Tea Pigment by RP-HPLC
China Pharmacy 2005;0(21):-
OBJECTIVE:To establish an RP-HPLC method for the determination of Callic acid and Caffeine in tea pigment.METHODS:The separation of sample performed on Novapak ODS column(250 mm?4.6 mm,5.4 ?m).The mobile phase consisted of acetic acid-methanol-DMF-H2O(2∶3∶35∶160) with a flow rate of 1.0 mL?min-1 and detection wavelength of 280 nm.RESULTS:The linear ranges of Callic acid and Caffeine were 8.16~81.60 ?g?mL-1 and 2.84~28.40 ?g?mL-1.The average recovery rate of Callic acid was 99.8%(RSD=0.5%,n=6) and that of Caffeine was 99.9%(RSD=0.6%,n=6).CONCLUSION:The method is rapid,sensitive and accurate,and suitable for the quality control of tea pigment.
5.Inhibitory effect of Trichinella spiralis polypide protein on hepatic cancer cells H7402
Chinese Journal of Cancer Biotherapy 2006;0(05):-
Objective:To investigate the inhibitory effect of Trichinella spiralis polypide protein on H7402 cell line in vitro and to assess its anti-tumor effect against hepatocellular carcinoma(HCC).Methods:The Trichinella spiralis polyp- ide protein was isolated from adult worms and newborn mixture.Trichinella spiralis polypide protein was prepared through homogenization and centrifugation,and its concentrations were determined by UV-visable spectrometers.H7402 cells trea- ted with Trichinella spiralis polypide protein(at 0.035,0.070,0.140 mg/ml)served as treatment group,and normal he- patic cell line HL-7702 treated with Trichinella spiralis polypide protein served as control group.Cell proliferation was de- tected by MTT;the effect of Trichinella spiralis polypide protein on migration and invasion ability of H7402 cell line was assessed by scarification test and invasion test.Cell apoptosis was observed by TUNEL.Apoptosis and cell cycle were ana- lyzed by FCM.Results:Trichinella spiralis polypide protein was successfully prepared.The protein at 0.035,0.070,0. 140 mg/ml inhibited H7402 cells proliferation by(22.40?13.80)%,(29.45?16.80)%,and(39.38?17.80)%, respectively.Apoptosis was observed by TUNEL and FCM,with an apoptosis rate of(39.07?0.90)%;the cell cycle was blocked at S phase.Scarification test and invasion test suggested that Trichinella spiralis polypide protein inhibited the migration and invasion of H7402 cell line,with the inhibition rate being(63.79?13.71)%.Conclusion:Trichinella spiralis polypide protein can inhibit the proliferation,migration,invision of H7402 cell line,and it might be a potential anti-cancer agent.
6.Human-oriented Thought of Questions on Typhoid Theory(Shanghan Zhiyi)
International Journal of Traditional Chinese Medicine 2009;31(1):15-16
Questions on Typhoid Theory is a representative academic book of ZHU Wei-ju,a well-known TCM doctor of Shanghai in the period of the republic of China.The thoughts of the book is based on human body itself,advocating focusing on body itself not diseases,self recovery and natural therapy.Because he put human in the first place,he got excellent therapeutic effects in clinic.
7.Application of phase image of susceptibility weighted imaging in differential diagnosis of intracerebral paramagnetic and diamagnetic materials
Chinese Journal of Radiology 2009;43(6):590-594
Objective To explore the susceptibility weighted imaging (SWI) appearance of paramagnetic and diamagnetic materials, its imaging theory, and its value of differential diagnosis from their appearance. Methods The diamagnetic and paramagnetic phantom were made and the X-Y axial SWI phase image of phantom then was obtained. Twenty-eight cases of intracerebral calcium and 21 cases of hemorrhage examined with MRI scan and CT scan were retrospectively investigated. The appearance of calcium and hemorrhage on SWI were analyzed and compared with their appearance on CT and conventional MRI. Results Phantom experiment indicated that the equator plane scan of diamagnetic sphere showed high signal in centre surrounded by low signal ring and high signal in two poles of sphere along Z axis of main magnetic field. The paramagnetic sphere appeared the opposite appearance of diamagnetic sphere with centre low signal surrounded by high signal ring in equator plane and low signal in two poles of sphere along Z axis of main magnetic field. The SWI manifestations of 4 cases of intracerebral sphere or sphere-like calcification ( chorioidal calcification) and 9 cases of sphere or sphere-like hemorrhage(2 cases of traumatic hemorrhage, 1 case of hypertension related basal ganglion hemorrhage, 4 cases of metastasis hemorrhage and 2 cases of cavernous hemangioma hemorrhage)were consistent with diamagnetic and paramagnetic sphere phantom respectively. Four cases of calcification in basal ganglion showed the mixed high and low signal. Seven cases of irregular calcification ( neoplastic calcification) aside from basal ganglion appeared complex appearance, though mainly in high signal. Other sphere or sphere-like calcification aside from basal ganglion ( 14 cases of pineal calcification, 4 cases of chorioidal calcification, 2 cases of cerebral cysticercosis calcification and 1 case of neoplastic calcification ) showed markedly high signal. Nine cases of intracerebral iobular hemorrhage (2 cases of hypertension related basal ganglion hemorrhage, 4 cases of unknown casual hemmorrhge and 3 cases of cavernous hemangioma hemorrhage) displayed a multiple concentric circle appearance, other 3 hemorrhage showed complex appearance, though mainly in low signal. Ten cases of calcification had no specific appearance on T1 WI and T2WI. Conclusion Phase image of SWI is helpful in differentiating intracerebral diamagnetic from paramagnetic materials and it has some advantage in detecting calcification over T WI and T2 WI.
8.Briefly on Academic Thoughts in Huo You Xin Shu
China Journal of Traditional Chinese Medicine and Pharmacy 2005;0(05):-
The Book of Huo You Xin Shu was written by Zeng Shirong,a famous pediatrics doctor in Yuan Dynasty.Based on his ancestors' experiences,together with his own long-term clinical practices,this book discussed critically on issues of how to nurture children and the treatment based on syndrome differentiation. He promoted the concept of scientific nurture and criticized the problems associated with in bringing up children.He suggested that every aspect of the children's daily life must be taken care of under the guidance of scientific recommendations in order to allow children to growth up healthily.Prophylaxis should go ahead of treatment.He mentioned the importance to carefully investigate in the causes and origins of diseases and to accurately distinguish between the exterior signs and interior causes.For an acute case,symptoms should be dealt with first,while for a chronic one the root cause is treated.He pointed out this principle to remind us a dire consequence may be caused due to misdiagnosis and rash treatment.Before the treatment,we have to differentiate between exterior and interior,cold and heat,deficiency and excess,and follow the principle of simultaneous treatment of both exterior and interior,elimination and reinforcement.Moreover,he paid special attention to the effect of Spleen and Stomach functions in developing pediatrics diseases,emphasizing the importance of regulating them in pediatrics treatment.He was the first person to initiate the concept of "four causes of infantile convulsion(Si Zheng)"and "eight syndromes in infantile convulsion(Ba Hou)".He thought that we ought to investigate the causes of disease,catch the key of pathogenesis,pay great attention to the Qi activity,and the most importantly,regulate Qi activity in treatment.
9.CT and MRI Diagnosis of Osteoblastoma:A Reprot of 12 Cases
Journal of Practical Radiology 1996;0(04):-
Objective To study CT and MRI value in diagnosis of osteoblastoma,in order to achive more information about the disease. Methods The clinical,CT,MRI and histological data of 12 patients with osteoblastomas. Results(1)There were 6 patients wereexamined by CT,the lesions showed mainly lytic with varying degrees of matrix mineralisation,and mild adjacent reactive sclerosis;(2)10 patients were examined by MRI(included 4 patients who have been examined by CT),the lesions presented mixed signal intensity with compart,slightly low and intermediate signal intensity on T_1-weighted images,high signal intensity on T_2-weighted images were found in 9 cases and mainly low signal intensity was found in 1 case.8 cases showed clear low signal intensity surrounding the lension borh on T_1 and T_2,2 cases showed blurry high signal in the adjacent tissue;(3) The tumors presented moderate enhancemen with low dense area inside the lesions after injection of contrast media. Conclusion Osteoblastomas have classical features on CT,while show no characteristic appearances on MRI.
10.A CLINICAL AND PATHOLOGICAL STUDY OF TRAUMATIC NEUROMA
Medical Journal of Chinese People's Liberation Army 1983;0(05):-
22 cases of posttraumatic neuroma (TN) were seen in Kunming General Hospital from 1979 to 1985.Clinical and pathologycal study showed that:(1) One of the main causative factors of TN was wound infection.(2)It took at least 6 months to form a TN.Those TN which formed within 6 months belonged to chronic proliferative inflammation.(3)Four Clinical and pathological findings were necessary to diagnosis TN.(4) The term,tumor-like nerve hyperplasia.not only a more accurate term than TN.but also helps avoid misunderstanding.